| UniProt ID | RTG1_YEAST | |
|---|---|---|
| UniProt AC | P32607 | |
| Protein Name | Retrograde regulation protein 1 | |
| Gene Name | RTG1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 177 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Required for a novel path of interorganelle communication between mitochondria, peroxisomes and the nucleus, thereby maintaining a functional metabolic interaction between the tricarboxylic acid and glyoxylate cycles. Transcription factor that regulates CIT2 gene expression. Binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (UASR) in the CIT2 promoter. The core binding site is 5'-GGTCAC-3'.. | |
| Protein Sequence | MSSIPAGTDPGSCGANFKNDRKRRDKINDRIQELLSIIPKDFFRDYYGNSGSNDTLSESTPGALGLSSKAKGTGTKDGKPNKGQILTQAVEYISHLQNQVDTQNREEVELMVKATQLAKQTGTIVNDINLENTSAEVALSRIGVGPLAATNDDSVRPPAKRLSSFEYGGYGEYGNGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSIPAGTD ------CCCCCCCCC | 36.65 | 28152593 | |
| 3 | Phosphorylation | -----MSSIPAGTDP -----CCCCCCCCCC | 31.15 | 28152593 | |
| 8 | Phosphorylation | MSSIPAGTDPGSCGA CCCCCCCCCCCCCCC | 40.92 | 19823750 | |
| 12 | Phosphorylation | PAGTDPGSCGANFKN CCCCCCCCCCCCCCC | 18.11 | 28152593 | |
| 46 | Phosphorylation | PKDFFRDYYGNSGSN CHHHHHHHHCCCCCC | 14.71 | 22369663 | |
| 47 | Phosphorylation | KDFFRDYYGNSGSND HHHHHHHHCCCCCCC | 17.70 | 22369663 | |
| 50 | Phosphorylation | FRDYYGNSGSNDTLS HHHHHCCCCCCCCCC | 38.95 | 22369663 | |
| 52 | Phosphorylation | DYYGNSGSNDTLSES HHHCCCCCCCCCCCC | 31.21 | 22369663 | |
| 55 | Phosphorylation | GNSGSNDTLSESTPG CCCCCCCCCCCCCCC | 36.11 | 22369663 | |
| 57 | Phosphorylation | SGSNDTLSESTPGAL CCCCCCCCCCCCCCC | 31.43 | 22369663 | |
| 59 | Phosphorylation | SNDTLSESTPGALGL CCCCCCCCCCCCCCC | 36.20 | 22369663 | |
| 60 | Phosphorylation | NDTLSESTPGALGLS CCCCCCCCCCCCCCC | 22.99 | 22369663 | |
| 67 | Phosphorylation | TPGALGLSSKAKGTG CCCCCCCCCCCCCCC | 28.17 | 22369663 | |
| 68 | Phosphorylation | PGALGLSSKAKGTGT CCCCCCCCCCCCCCC | 41.49 | 22369663 | |
| 160 | Acetylation | DSVRPPAKRLSSFEY CCCCCCCCCCCCCCC | 60.69 | 25381059 | |
| 163 | Phosphorylation | RPPAKRLSSFEYGGY CCCCCCCCCCCCCCC | 36.69 | 22369663 | |
| 164 | Phosphorylation | PPAKRLSSFEYGGYG CCCCCCCCCCCCCCC | 27.04 | 22369663 | |
| 167 | Phosphorylation | KRLSSFEYGGYGEYG CCCCCCCCCCCCCCC | 17.53 | 22369663 | |
| 170 | Phosphorylation | SSFEYGGYGEYGNGS CCCCCCCCCCCCCCC | 11.47 | 22369663 | |
| 177 | Phosphorylation | YGEYGNGS------- CCCCCCCC------- | 40.84 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RTG1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RTG1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RTG1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; THR-55; SER-164 ANDSER-177, AND MASS SPECTROMETRY. | |
