dbPTM

TOM22_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TOM22_YEAST
UniProt AC	P49334
Protein Name	Mitochondrial import receptor subunit TOM22
Gene Name	TOM22
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	152
Subcellular Localization	Mitochondrion outer membrane Single-pass type II membrane protein.
Protein Description	Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating..
Protein Sequence	MVELTEIKDDVVQLDEPQFSRNQAIVEEKASATNNDVVDDEDDSDSDFEDEFDENETLLDRIVALKDIVPPGKRQTISNFFGFTSSFVRNAFTKSGNLAWTLTTTALLLGVPLSLSILAEQQLIEMEKTFDLQSDANNILAQGEKDAAATAN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MVELTEIKDDVVQLD CCCCEECCCCEEECC	41.46	24961812
20	Phosphorylation	QLDEPQFSRNQAIVE ECCCCCCCCCHHHHH	25.69	24909858
31	Phosphorylation	AIVEEKASATNNDVV HHHHHHHHHCCCCCC	46.85	23749301
33	Phosphorylation	VEEKASATNNDVVDD HHHHHHHCCCCCCCC	31.87	23749301
44	Phosphorylation	VVDDEDDSDSDFEDE CCCCCCCCCCCCCHH	51.87	19823750
46	Phosphorylation	DDEDDSDSDFEDEFD CCCCCCCCCCCHHCC	48.42	19823750
57	Phosphorylation	DEFDENETLLDRIVA HHCCCCHHHHHHHHH	44.17	23749301
66	Ubiquitination	LDRIVALKDIVPPGK HHHHHHHHHCCCCCC	35.35	23749301
66	Acetylation	LDRIVALKDIVPPGK HHHHHHHHHCCCCCC	35.35	24489116
134	Phosphorylation	EKTFDLQSDANNILA HHHHCCCCHHHCHHH	46.09	21440633
145	Ubiquitination	NILAQGEKDAAATAN CHHHHCHHHHHHHCC	60.54	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TOM22_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TOM22_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TOM22_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TOM20_YEAST	TOM20	physical	9774667
TOM40_YEAST	TOM40	physical	11276259
TOM40_YEAST	TOM40	physical	11866524
TOM20_YEAST	TOM20	physical	11866524
BCS1_YEAST	BCS1	physical	12640110
TOM22_YEAST	TOM22	physical	8754801
TOM20_YEAST	TOM20	physical	8641278
TIM21_YEAST	TIM21	physical	17099692
TOM20_YEAST	TOM20	physical	18706915
TOM40_YEAST	TOM40	physical	18706915
PEX34_YEAST	PEX34	physical	18719252
TOM20_YEAST	TOM20	physical	10436009
TOM40_YEAST	TOM40	physical	16093310
TIM21_YEAST	TIM21	physical	19884344
TIM23_YEAST	TIM23	physical	19884344
TIM44_YEAST	TIM44	physical	19884344
TIM16_YEAST	PAM16	physical	19884344
TIM14_YEAST	PAM18	physical	19884344
UPS2_YEAST	UPS2	physical	20622808
MDM10_YEAST	MDM10	physical	21036907
TOM7_YEAST	TOM7	physical	21036907
TOM40_YEAST	TOM40	physical	21215441
TIM23_YEAST	TIM23	physical	21215441
VDAC1_YEAST	POR1	physical	21215441
OM45_YEAST	OM45	physical	21215441
ATPB_YEAST	ATP2	physical	21215441
CSK21_YEAST	CKA1	physical	21215441
CSK22_YEAST	CKA2	physical	21215441
TOM20_YEAST	TOM20	physical	21896724
TOM40_YEAST	TOM40	physical	21896724
TIM50_YEAST	TIM50	physical	21896724
DAP1_YEAST	DAP1	physical	22940862
PSD1_YEAST	PSD1	physical	22984266
ATP9_NEUCR	NCU02250	physical	21173275
TIM22_YEAST	TIM22	physical	23283984
TOM40_YEAST	TOM40	physical	23283984
TOM70_YEAST	TOM70	physical	23283984
TOM40_YEAST	TOM40	physical	25002531
TOM5_YEAST	TOM5	physical	25002531
TOM40_YEAST	TOM40	genetic	25002531
SAM50_YEAST	SAM50	physical	26416958
SAM37_YEAST	SAM37	physical	26416958
SAM35_YEAST	SAM35	physical	26416958
TOM7_YEAST	TOM7	physical	26416958
TOM20_YEAST	TOM20	physical	26416958
TOM40_YEAST	TOM40	physical	26416958
TOM40_YEAST	TOM40	physical	25008211
TIM23_YEAST	TIM23	physical	25008211
TIM21_YEAST	TIM21	physical	25008211
TIM44_YEAST	TIM44	physical	25008211
TIM16_YEAST	PAM16	physical	25008211
TIM14_YEAST	PAM18	physical	25008211
TOM40_YEAST	TOM40	physical	23911324
TOM7_YEAST	TOM7	physical	23911324
TOM20_YEAST	TOM20	physical	23911324
TOM70_YEAST	TOM70	physical	23911324
SAM50_YEAST	SAM50	physical	23911324
SAM37_YEAST	SAM37	physical	23911324
SAM35_YEAST	SAM35	physical	23911324

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TOM22_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44 AND SER-46, AND MASSSPECTROMETRY.	18407956 [Abstract]