| UniProt ID | CSK21_YEAST | |
|---|---|---|
| UniProt AC | P15790 | |
| Protein Name | Casein kinase II subunit alpha | |
| Gene Name | CKA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 372 | |
| Subcellular Localization | ||
| Protein Description | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. May play a role in cell proliferation. Required for cell viability.. | |
| Protein Sequence | MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | RTEEYWDYENTVIDW CCHHHCCCCCCEEEC | 9.27 | 28132839 | |
| 45 | Acetylation | KDYEIENKVGRGKYS CCEEEECCCCCCCCH | 33.02 | 24489116 | |
| 50 | Acetylation | ENKVGRGKYSEVFQG ECCCCCCCCHHHHCC | 44.22 | 24489116 | |
| 93 | Acetylation | LTDLSNEKVPPTTLP HHHCCCCCCCCCCCC | 65.38 | 24489116 | |
| 166 | Acetylation | DFRILYPKLTDLEIR EEEEECCCCCHHHHH | 50.92 | 24489116 | |
| 237 | Acetylation | RVASRFFKGPELLVD CHHHHHHCCCEEEEE | 71.49 | 24489116 | |
| 283 | Acetylation | SNTDQLVKIVKVLGT CCHHHHHHHHHHHCC | 50.83 | 24489116 | |
| 286 | Acetylation | DQLVKIVKVLGTSDF HHHHHHHHHHCCCHH | 34.90 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CSK21_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CSK21_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CSK21_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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