PPT1_YEAST - dbPTM
PPT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPT1_YEAST
UniProt AC P53043
Protein Name Serine/threonine-protein phosphatase T
Gene Name PPT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 513
Subcellular Localization Nucleus .
Protein Description Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90 (HSC82 and HSP82). Dephosphorylation positively regulates the Hsp90 chaperone machinery..
Protein Sequence MSTPTAADRAKALERKNEGNVFVKEKHFLKAIEKYTEAIDLDSTQSIYFSNRAFAHFKVDNFQSALNDCDEAIKLDPKNIKAYHRRALSCMALLEFKKARKDLNVLLKAKPNDPAATKALLTCDRFIREERFRKAIGGAENEAKISLCQTLNLSSFDANADLANYEGPKLEFEQLYDDKNAFKGAKIKNMSQEFISKMVNDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELENNSTPDVKISVCGDTHGQFYDVLNLFRKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQEANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVVPGHGILQAGRNDDQNLIIETFEAVEHPDIKPMAYSNGGFGL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSTPTAADR
------CCCCCHHHH		42.9927717283
3Phosphorylation-----MSTPTAADRA
-----CCCCCHHHHH		24.3027717283
5Phosphorylation---MSTPTAADRAKA
---CCCCCHHHHHHH		34.2727717283
35PhosphorylationFLKAIEKYTEAIDLD
HHHHHHHHHHCCCCC		9.3119779198
36PhosphorylationLKAIEKYTEAIDLDS
HHHHHHHHHCCCCCC		29.9719779198
48PhosphorylationLDSTQSIYFSNRAFA
CCCCCEEEECCCCEE		13.2519779198
89PhosphorylationAYHRRALSCMALLEF
HHHHHHHHHHHHHHH		10.8130377154
97AcetylationCMALLEFKKARKDLN
HHHHHHHHHHHHHHH		35.8324489116
101AcetylationLEFKKARKDLNVLLK
HHHHHHHHHHHHHEE		72.0024489116
154PhosphorylationLCQTLNLSSFDANAD
HHHHCCCCCCCCCCC		28.0827017623
165PhosphorylationANADLANYEGPKLEF
CCCCHHCCCCCCCCH		19.3627017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HSC82_YEASTHSC82physical
11805826
HSP82_YEASTHSP82physical
11805826
ADR1_YEASTADR1physical
10688190
HSC82_YEASTHSC82physical
16554755
2A5D_YEASTRTS1physical
16554755
SBA1_YEASTSBA1physical
18719252
SLX9_YEASTSLX9genetic
19269370
HSP82_YEASTHSP82physical
16407978
ASK10_YEASTASK10genetic
21127252
HSF_YEASTHSF1physical
24894977
HSC82_YEASTHSC82genetic
24923785
RPA14_YEASTRPA14genetic
27708008
PALA_YEASTRIM20genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
GEM1_YEASTGEM1genetic
27708008
YCA2_YEASTYCL002Cgenetic
27708008
UGA4_YEASTUGA4genetic
27708008
HNT2_YEASTHNT2genetic
27708008
SNF1_YEASTSNF1genetic
27708008
DMC1_YEASTDMC1genetic
27708008
SODM_YEASTSOD2genetic
27708008
ARO9_YEASTARO9genetic
27708008
YH02_YEASTYHR202Wgenetic
27708008
CRG1_YEASTCRG1genetic
27708008
TED1_YEASTTED1genetic
27708008
AVT7_YEASTAVT7genetic
27708008
IMA5_YEASTIMA5genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
AIM25_YEASTAIM25genetic
27708008
ENT3_YEASTENT3genetic
27708008
MDM35_YEASTMDM35genetic
27708008
ACE2_YEASTACE2genetic
27708008
PUT1_YEASTPUT1genetic
27708008
POC1_YEASTPBA1genetic
27708008
ELP1_YEASTIKI3genetic
27708008
PPZ1_YEASTPPZ1genetic
27708008
RCF1_YEASTRCF1genetic
27708008
YML9_YEASTYML119Wgenetic
27708008
PKR1_YEASTPKR1genetic
27708008
SSO2_YEASTSSO2genetic
27708008
RS10B_YEASTRPS10Bgenetic
27708008
ASI3_YEASTASI3genetic
27708008
SWS2_YEASTSWS2genetic
27708008
COQ2_YEASTCOQ2genetic
27708008
DCAM_YEASTSPE2genetic
27708008
MSN1_YEASTMSN1genetic
27708008
TRM11_YEASTTRM11genetic
27708008
RTC1_YEASTRTC1genetic
27708008
PIN2_YEASTPIN2genetic
27708008
VPS17_YEASTVPS17genetic
27708008
FABD_YEASTMCT1genetic
27708008
FSF1_YEASTFSF1genetic
27708008
RDL2_YEASTRDL2genetic
27708008
MBF1_YEASTMBF1genetic
27708008
YO304_YEASTBIL1genetic
27708008
PHR_YEASTPHR1genetic
27708008
SRL4_YEASTSRL4genetic
27708008
YP034_YEASTYPL034Wgenetic
27708008
PMA2_YEASTPMA2genetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
LEE1_YEASTLEE1genetic
27708008
ELP4_YEASTELP4genetic
27708008
NTO1_YEASTNTO1genetic
27708008
OPY2_YEASTOPY2genetic
27708008
YP078_YEASTYPR078Cgenetic
27708008
YP098_YEASTYPR098Cgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPT1_YEAST

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Related Literatures of Post-Translational Modification

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