| UniProt ID | PHR_YEAST | |
|---|---|---|
| UniProt AC | P05066 | |
| Protein Name | Deoxyribodipyrimidine photo-lyase, mitochondrial | |
| Gene Name | PHR1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 565 | |
| Subcellular Localization | Nucleus. Mitochondrion. | |
| Protein Description | Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.. | |
| Protein Sequence | MKRTVISSSNAYASKRSRLDIEHDFEQYHSLNKKYYPRPITRTGANQFNNKSRAKPMEIVEKLQKKQKTSFENVSTVMHWFRNDLRLYDNVGLYKSVALFQQLRQKNAKAKLYAVYVINEDDWRAHMDSGWKLMFIMGALKNLQQSLAELHIPLLLWEFHTPKSTLSNSKEFVEFFKEKCMNVSSGTGTIITANIEYQTDELYRDIRLLENEDHRLQLKYYHDSCIVAPGLITTDRGTNYSVFTPWYKKWVLYVNNYKKSTSEICHLHIIEPLKYNETFELKPFQYSLPDEFLQYIPKSKWCLPDVSEEAALSRLKDFLGTKSSKYNNEKDMLYLGGTSGLSVYITTGRISTRLIVNQAFQSCNGQIMSKALKDNSSTQNFIKEVAWRDFYRHCMCNWPYTSMGMPYRLDTLDIKWENNPVAFEKWCTGNTGIPIVDAIMRKLLYTGYINNRSRMITASFLSKNLLIDWRWGERWFMKHLIDGDSSSNVGGWGFCSSTGIDAQPYFRVFNMDIQAKKYDPQMIFVKQWVPELISSENKRPENYPKPLVDLKHSRERALKVYKDAM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Acetylation | SSNAYASKRSRLDIE CCCHHCCCCCCCCCC | 46.34 | 22865919 | |
| 197 | Phosphorylation | IITANIEYQTDELYR EEECEEEEECHHHHH | 16.96 | 19779198 | |
| 203 | Phosphorylation | EYQTDELYRDIRLLE EEECHHHHHHHHHHH | 12.28 | 19779198 | |
| 220 | Phosphorylation | DHRLQLKYYHDSCIV CCCEEHHHCCCCEEE | 18.02 | 28889911 | |
| 221 | Phosphorylation | HRLQLKYYHDSCIVA CCEEHHHCCCCEEEE | 9.51 | 28889911 | |
| 377 | Phosphorylation | KALKDNSSTQNFIKE HHHCCCCCHHHHHHH | 40.02 | 27017623 | |
| 378 | Phosphorylation | ALKDNSSTQNFIKEV HHCCCCCHHHHHHHH | 27.61 | 27017623 | |
| 400 | Phosphorylation | HCMCNWPYTSMGMPY HHHCCCCCCCCCCCE | 11.76 | 28889911 | |
| 401 | Phosphorylation | CMCNWPYTSMGMPYR HHCCCCCCCCCCCEE | 14.25 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PHR_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PHR_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PHR_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SYDM_YEAST | MSD1 | physical | 11805837 | |
| HAT2_YEAST | HAT2 | physical | 16554755 | |
| DOP1_YEAST | DOP1 | genetic | 21987634 | |
| IPK1_YEAST | IPK1 | genetic | 21987634 | |
| IPYR2_YEAST | PPA2 | genetic | 21987634 | |
| FCF1_YEAST | FCF1 | genetic | 27708008 | |
| CWC16_YEAST | YJU2 | genetic | 27708008 | |
| TAD3_YEAST | TAD3 | genetic | 27708008 | |
| ORC1_YEAST | ORC1 | genetic | 27708008 | |
| RNA1_YEAST | RNA1 | genetic | 27708008 | |
| SEC12_YEAST | SEC12 | genetic | 27708008 | |
| SEC23_YEAST | SEC23 | genetic | 27708008 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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