| UniProt ID | RNA1_YEAST | |
|---|---|---|
| UniProt AC | P11745 | |
| Protein Name | Ran GTPase-activating protein 1 | |
| Gene Name | RNA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 407 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | GTPase activator for the nuclear Ras-related regulatory protein GSP1 (Ran), converting it to the putatively inactive GDP-bound state.. | |
| Protein Sequence | MATLHFVPQHEEEQVYSISGKALKLTTSDDIKPYLEELAALKTCTKLDLSGNTIGTEASEALAKCIAENTQVRESLVEVNFADLYTSRLVDEVVDSLKFLLPVLLKCPHLEIVNLSDNAFGLRTIELLEDYIAHAVNIKHLILSNNGMGPFAGERIGKALFHLAQNKKAASKPFLETFICGRNRLENGSAVYLALGLKSHSEGLKVVKLYQNGIRPKGVATLIHYGLQYLKNLEILDLQDNTFTKHASLILAKALPTWKDSLFELNLNDCLLKTAGSDEVFKVFTEVKFPNLHVLKFEYNEMAQETIEVSFLPAMEKGNLPELEKLEINGNRLDEDSDALDLLQSKFDDLEVDDFEEVDSEDEEGEDEEDEDEDEKLEEIETERLEKELLEVQVDDLAERLAETEIK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 | Phosphorylation | HEEEQVYSISGKALK CCCEEEEEEECEEEE | 16.06 | 30377154 | |
| 21 | Acetylation | QVYSISGKALKLTTS EEEEEECEEEECCCC | 43.70 | 24489116 | |
| 32 | Acetylation | LTTSDDIKPYLEELA CCCCCHHHHHHHHHH | 34.31 | 24489116 | |
| 46 | Acetylation | AALKTCTKLDLSGNT HHHHCCCEECCCCCC | 41.99 | 24489116 | |
| 144 | Phosphorylation | NIKHLILSNNGMGPF CCCEEECCCCCCCCC | 22.66 | 22369663 | |
| 172 | Acetylation | QNKKAASKPFLETFI HCCHHCCCCHHHHEE | 34.75 | 24489116 | |
| 253 | Acetylation | HASLILAKALPTWKD HHHHHHHHHCCCCCH | 47.19 | 24489116 | |
| 282 | Acetylation | AGSDEVFKVFTEVKF CCCCHHHHHEEEECC | 41.43 | 24489116 | |
| 288 | Acetylation | FKVFTEVKFPNLHVL HHHEEEECCCCEEEE | 49.20 | 24489116 | |
| 337 | Phosphorylation | GNRLDEDSDALDLLQ CCCCCCCCHHHHHHH | 23.80 | 28889911 | |
| 360 | Phosphorylation | DDFEEVDSEDEEGED CCHHCCCCCCCCCCC | 52.72 | 17330950 | |
| 382 | Phosphorylation | EKLEEIETERLEKEL HHHHHHHHHHHHHHH | 31.87 | 26447709 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RNA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RNA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RNA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-360, AND MASSSPECTROMETRY. | |
