| UniProt ID | RNH2B_YEAST | |
|---|---|---|
| UniProt AC | Q05635 | |
| Protein Name | Ribonuclease H2 subunit B | |
| Gene Name | RNH202 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 350 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.. | |
| Protein Sequence | MTVSNIGGEERLIILPDDYETSKTINTFTLPPPSNITSKPRIELFENINGKLYEIRSFQFGKGPSYSHEEDLANDKYHYTKENHPIKSTFIVNTSDPTDGYVFNSSKIHFCSLYDIAFSLIGFYYRNSVSADEQDYSNSSDTGENQKSNSKTNEKFLTVRDYHDFLTDNHDKNWENISLSRLKSGLAKVSETIEEAGDVYYKITSAMITQFLLGKVSKIVENFPPSIPTLKNAPTEIKQCYKVVMATNLLVSLIPRAAYHNLLTFSPTMDSGCLNPDIKASFIELENYETTNELQNAERELLMKSAMNVGLNSNGRVSLPVKKVTKKIVQNKKPKVAIGKGAIDGFFKRK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | LIILPDDYETSKTIN EEECCCCCCCCCEEE | 28.61 | 19779198 | |
| 21 | Phosphorylation | ILPDDYETSKTINTF ECCCCCCCCCEEEEE | 29.33 | 19779198 | |
| 22 | Phosphorylation | LPDDYETSKTINTFT CCCCCCCCCEEEEEE | 18.83 | 19779198 | |
| 62 | Acetylation | IRSFQFGKGPSYSHE EEEEECCCCCCCCCH | 69.78 | 22865919 | |
| 88 | Phosphorylation | KENHPIKSTFIVNTS CCCCCCCEEEEEECC | 29.30 | 20377248 | |
| 89 | Phosphorylation | ENHPIKSTFIVNTSD CCCCCCEEEEEECCC | 16.63 | 20377248 | |
| 105 | Phosphorylation | TDGYVFNSSKIHFCS CCCEEECCCCEEEEE | 22.88 | 20377248 | |
| 106 | Phosphorylation | DGYVFNSSKIHFCSL CCEEECCCCEEEEEH | 36.41 | 20377248 | |
| 136 | Phosphorylation | VSADEQDYSNSSDTG CCCCCCCCCCCCCCC | 14.94 | 28889911 | |
| 137 | Phosphorylation | SADEQDYSNSSDTGE CCCCCCCCCCCCCCC | 38.23 | 28889911 | |
| 139 | Phosphorylation | DEQDYSNSSDTGENQ CCCCCCCCCCCCCCC | 24.53 | 28889911 | |
| 140 | Phosphorylation | EQDYSNSSDTGENQK CCCCCCCCCCCCCCC | 43.36 | 23749301 | |
| 204 | Phosphorylation | GDVYYKITSAMITQF HHHHHHHHHHHHHHH | 13.28 | 28889911 | |
| 205 | Phosphorylation | DVYYKITSAMITQFL HHHHHHHHHHHHHHH | 21.22 | 28889911 | |
| 209 | Phosphorylation | KITSAMITQFLLGKV HHHHHHHHHHHHHHH | 10.53 | 28889911 | |
| 226 | Phosphorylation | IVENFPPSIPTLKNA HHHHCCCCCCCCCCC | 41.25 | 28889911 | |
| 229 | Phosphorylation | NFPPSIPTLKNAPTE HCCCCCCCCCCCCHH | 49.01 | 28889911 | |
| 241 | Phosphorylation | PTEIKQCYKVVMATN CHHHHHHHHHHHHHH | 12.34 | 28132839 | |
| 340 | Acetylation | KPKVAIGKGAIDGFF CCCEEECCCCCCCCC | 38.77 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RNH2B_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RNH2B_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RNH2B_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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