| UniProt ID | TAP42_YEAST | |
|---|---|---|
| UniProt AC | Q04372 | |
| Protein Name | Type 2A phosphatase-associated protein 42 | |
| Gene Name | TAP42 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 366 | |
| Subcellular Localization | ||
| Protein Description | Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Inhibitor of PP2A phosphatase SIT4, which results in inhibition of nuclear export of MSN2, due to lack of dephosphorylation by SIT4. Also required for rapamycin induced activation of expression of many nitrogen discrimination pathway (NDP) genes. In complex with PPH21, required for organization of the actin cytoskeletom during the cell cycle via a Rho GTPase-dependent mechanism.. | |
| Protein Sequence | MASVTEQFNDIISLYSTKLEHTSLRQDSPEYQGLLLSTIKKLLNLKTAIFDRLALFSTNETIDDVSTASIKFLAVDYYLGLLISRRQSNDSDVAQRQSMKLIYLKKSVESFINFLTLLQDYKLLDPLVGEKLGNFKDRYNPQLSELYAQPKNNKDLSGAQLKRKEKIELFQRNKEISTKLHCLELELKNNDEDHDHDELLRELYLMRLHHFSLDTINNIEQNLFECEMLSNFLKNSVHEVKSSGTQIRKESNDDDSTGFTDKLENINKPLIDKKGQVLRNFTLVDKRQQLQQKVRGYGQYGPTMSVEEFLDKEFEEGRVLQGGEEPEQAPDEENMDWQDRETYKAREWDEFKESHAKGSGNTMNRG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 61 | Phosphorylation | ALFSTNETIDDVSTA HHCCCCCCCCCCHHH | 31.60 | 27017623 | |
| 67 | Phosphorylation | ETIDDVSTASIKFLA CCCCCCHHHHHHHHH | 25.03 | 27017623 | |
| 69 | Phosphorylation | IDDVSTASIKFLAVD CCCCHHHHHHHHHHH | 26.80 | 27017623 | |
| 204 | Phosphorylation | DELLRELYLMRLHHF HHHHHHHHHHHHHHC | 8.16 | 25533186 | |
| 251 | Phosphorylation | GTQIRKESNDDDSTG CCEEEHHCCCCCCCC | 48.90 | 28889911 | |
| 256 | Phosphorylation | KESNDDDSTGFTDKL HHCCCCCCCCCHHHH | 37.11 | 28889911 | |
| 282 | Phosphorylation | GQVLRNFTLVDKRQQ CCEECCCEECCHHHH | 29.44 | 28889911 | |
| 293 | Acetylation | KRQQLQQKVRGYGQY HHHHHHHHHCCCCCC | 22.42 | 25381059 | |
| 305 | Phosphorylation | GQYGPTMSVEEFLDK CCCCCCCCHHHHHHH | 28.93 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TAP42_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TAP42_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TAP42_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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