| UniProt ID | MTW1_YEAST | |
|---|---|---|
| UniProt AC | P39731 | |
| Protein Name | Kinetochore-associated protein MTW1 | |
| Gene Name | MTW1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 289 | |
| Subcellular Localization | Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle pole . Associated with the kinetochore. | |
| Protein Description | Acts as essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity. MIND plays a role in establishing a bipolar spindle-kinetochore interaction by joining kinetochore subunits contacting DNA to those contacting microtubules.. | |
| Protein Sequence | MSAPTMRSTSILTEHLGYPPISLVDDIINAVNEIMYKCTAAMEKYLLSKSKIGEEDYGEEIKSGVAKLESLLENSVDKNFDKLELYVLRNVLRIPEEYLDANVFRLENQKDLVIVDENELKKSEEKLREKVNDVELAFKKNEMLLKRVTKVKRLLFTIRGFKQKLNELLKCKDDVQLQKILESLKPIDDTMTLLTDSLRKLYVDSESTSSTEEVEALLQRLKTNGKQNNKDFRTRYIDIRTNNVLRKLGLLGDKEDEKQSAKPDARTQAGDIVSIDIEEPQLDLLDDVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 110 | Ubiquitination | VFRLENQKDLVIVDE EEECCCCCCEEEECH | 65.69 | 23749301 | |
| 202 | Phosphorylation | TDSLRKLYVDSESTS HHHHHHHHCCCCCCC | 12.78 | 29688323 | |
| 205 | Phosphorylation | LRKLYVDSESTSSTE HHHHHCCCCCCCCHH | 24.33 | 29688323 | |
| 207 | Phosphorylation | KLYVDSESTSSTEEV HHHCCCCCCCCHHHH | 37.23 | 29688323 | |
| 208 | Phosphorylation | LYVDSESTSSTEEVE HHCCCCCCCCHHHHH | 23.73 | 29688323 | |
| 209 | Phosphorylation | YVDSESTSSTEEVEA HCCCCCCCCHHHHHH | 44.54 | 29688323 | |
| 210 | Phosphorylation | VDSESTSSTEEVEAL CCCCCCCCHHHHHHH | 39.67 | 29688323 | |
| 211 | Phosphorylation | DSESTSSTEEVEALL CCCCCCCHHHHHHHH | 35.61 | 29688323 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MTW1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MTW1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MTW1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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