| UniProt ID | SPC24_YEAST | |
|---|---|---|
| UniProt AC | Q04477 | |
| Protein Name | Kinetochore protein SPC24 | |
| Gene Name | SPC24 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 213 | |
| Subcellular Localization | Nucleus . Chromosome, centromere, kinetochore . Associated with kinetochores. | |
| Protein Description | Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity.. | |
| Protein Sequence | MSQKDNLLDNPVEFLKEVRESFDIQQDVDAMKRIRHDLDVIKEESEARISKEHSKVSESNKKLNAERINVAKLEGDLEYTNEESNEFGSKDELVKLLKDLDGLERNIVSLRSELDEKMKLYLKDSEIISTPNGSKIKAKVIEPELEEQSAVTPEANENILKLKLYRSLGVILDLENDQVLINRKNDGNIDILPLDNNLSDFYKTKYIWERLGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSQKDNLLD ------CCHHHCCCC | 46.03 | 22814378 | |
| 2 | Phosphorylation | ------MSQKDNLLD ------CCHHHCCCC | 46.03 | 28132839 | |
| 42 | Acetylation | RHDLDVIKEESEARI HHHHHHHHHHHHHHH | 56.10 | 24489116 | |
| 98 | Acetylation | DELVKLLKDLDGLER HHHHHHHHHCCHHHH | 67.68 | 24489116 | |
| 125 | Phosphorylation | MKLYLKDSEIISTPN HHHHHCCCCEEECCC | 29.16 | 28889911 | |
| 129 | Phosphorylation | LKDSEIISTPNGSKI HCCCCEEECCCCCCE | 43.40 | 22369663 | |
| 130 | Phosphorylation | KDSEIISTPNGSKIK CCCCEEECCCCCCEE | 15.46 | 22369663 | |
| 134 | Phosphorylation | IISTPNGSKIKAKVI EEECCCCCCEEEEEE | 37.54 | 22369663 | |
| 149 | Phosphorylation | EPELEEQSAVTPEAN CHHHHHHCCCCHHHC | 28.17 | 24961812 | |
| 152 | Phosphorylation | LEEQSAVTPEANENI HHHHCCCCHHHCHHH | 18.35 | 25752575 | |
| 199 | Phosphorylation | LPLDNNLSDFYKTKY EECCCCHHHHHHHHH | 28.00 | 25521595 | |
| 202 | Phosphorylation | DNNLSDFYKTKYIWE CCCHHHHHHHHHHHH | 23.80 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPC24_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPC24_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPC24_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-130, AND MASSSPECTROMETRY. | |
