| UniProt ID | BCK2_YEAST | |
|---|---|---|
| UniProt AC | P33306 | |
| Protein Name | Protein BCK2 | |
| Gene Name | BCK2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 851 | |
| Subcellular Localization | ||
| Protein Description | Dosage dependent suppressor of PKC1 deletion and MPK1 deletion. Involved in cell lysis.. | |
| Protein Sequence | MPKNSHHHRSSSVNSTKSRSTESTNKWKIPHYYRRSASGSTQASPDRNSSTGSCSTPVLPTMNVMSSPKKVLLEDPRDNHTKAKKSSRKKSGEMVFVNYTVQDTANENDTDLQTQPVSVPAPKAKLKKKSSKRRMLKIFGSSKNEHIEDIVEEQPMVLQMDSESKPLSGTPISESGIDASSLTTKRSYNSFLKHNRLNGKTPFSGNLSFPSLNMMGNTTDLPIDNNDFCSEKEVVPKSTHDPSLAKPPSRFTESETNSTPNLSSIPLMNTKNTRLKYNKVAPQSSDRQKSQESGLYHSTESFNFKDQNYSNNKSSLSLNSDLSTPHFAKHSPDSPRTSRSFNCGDSQSKVKLPEENDASIAFSKMFTRKRANTGGSTCSLASPTIAQTIQQSNIKVNKLPTQRTTSVGSLSSMSNRYSPIRVASPGRARSATRGSSLYRLSRDLNSLPSVTDLPEMDSTTPVNEIFLDGQPQHKSGSVKGGHRKKQESISDAQRIQHSNSYITTPSSSLVTPPYYMTGYTLPSSASASSTPNVLETHNMNFVPSTSTVTSYRPSSNFSSFDKEYSNENDASGEFSAFNTPMENIPALKGIPRSTLEENEEEDVLVQDIPNTAHFQRRDIMGMDTHRKDDSLDFNSLMPHGSTTSSSIVDSVMTNSISTTTSNATGNYFQDQDKYTLVNTGLGLSDANLDHFIRSQWKHASRSESNNNTGNRVSYSGSTPNNVDTTKTNLQVYTEFDFENPESFFHEQSKLLGEMGHSNNNSNSAINMNEPKSADTYIGNISPDTSATVSLGDLMGSNVSNNSERNFYDGHTFVPQYQANSSVENSNNQNAAPIANNDIDNNLQSFYFDNSN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | SHHHRSSSVNSTKSR CCCCCCCCCCCCCCC | 26.94 | 21551504 | |
| 15 | Phosphorylation | HRSSSVNSTKSRSTE CCCCCCCCCCCCCCC | 34.75 | 21551504 | |
| 36 | Phosphorylation | IPHYYRRSASGSTQA CCCEEECCCCCCCCC | 20.14 | 28889911 | |
| 38 | Phosphorylation | HYYRRSASGSTQASP CEEECCCCCCCCCCC | 34.23 | 28889911 | |
| 40 | Phosphorylation | YRRSASGSTQASPDR EECCCCCCCCCCCCC | 18.17 | 28889911 | |
| 44 | Phosphorylation | ASGSTQASPDRNSST CCCCCCCCCCCCCCC | 19.95 | 28889911 | |
| 50 | Phosphorylation | ASPDRNSSTGSCSTP CCCCCCCCCCCCCCC | 40.09 | 19779198 | |
| 53 | Phosphorylation | DRNSSTGSCSTPVLP CCCCCCCCCCCCCCC | 12.65 | 19779198 | |
| 61 | Phosphorylation | CSTPVLPTMNVMSSP CCCCCCCCCCCCCCC | 19.74 | 27017623 | |
| 66 | Phosphorylation | LPTMNVMSSPKKVLL CCCCCCCCCCCEEEC | 38.92 | 19779198 | |
| 67 | Phosphorylation | PTMNVMSSPKKVLLE CCCCCCCCCCEEECC | 23.73 | 28889911 | |
| 168 | Phosphorylation | DSESKPLSGTPISES CCCCCCCCCCCCCCC | 49.50 | 24961812 | |
| 170 | Phosphorylation | ESKPLSGTPISESGI CCCCCCCCCCCCCCC | 17.67 | 28889911 | |
| 180 | Phosphorylation | SESGIDASSLTTKRS CCCCCCHHHCCCHHH | 23.33 | 21440633 | |
| 184 | Phosphorylation | IDASSLTTKRSYNSF CCHHHCCCHHHHHHH | 29.74 | 21551504 | |
| 187 | Phosphorylation | SSLTTKRSYNSFLKH HHCCCHHHHHHHHHC | 30.16 | 21440633 | |
| 190 | Phosphorylation | TTKRSYNSFLKHNRL CCHHHHHHHHHCCCC | 24.59 | 30377154 | |
| 208 | Phosphorylation | TPFSGNLSFPSLNMM CCCCCCCCCCCCCCC | 38.83 | 21551504 | |
| 211 | Phosphorylation | SGNLSFPSLNMMGNT CCCCCCCCCCCCCCC | 30.30 | 21440633 | |
| 290 | Phosphorylation | QSSDRQKSQESGLYH CCCCHHHHHHHCCCC | 30.73 | 22369663 | |
| 293 | Phosphorylation | DRQKSQESGLYHSTE CHHHHHHHCCCCCCC | 26.85 | 22369663 | |
| 296 | Phosphorylation | KSQESGLYHSTESFN HHHHHCCCCCCCCCC | 9.39 | 22369663 | |
| 298 | Phosphorylation | QESGLYHSTESFNFK HHHCCCCCCCCCCCC | 21.95 | 22369663 | |
| 299 | Phosphorylation | ESGLYHSTESFNFKD HHCCCCCCCCCCCCC | 23.49 | 22369663 | |
| 301 | Phosphorylation | GLYHSTESFNFKDQN CCCCCCCCCCCCCCC | 26.11 | 22369663 | |
| 310 | Phosphorylation | NFKDQNYSNNKSSLS CCCCCCCCCCCCCEE | 41.29 | 19779198 | |
| 314 | Phosphorylation | QNYSNNKSSLSLNSD CCCCCCCCCEECCCC | 38.34 | 22369663 | |
| 315 | Phosphorylation | NYSNNKSSLSLNSDL CCCCCCCCEECCCCC | 24.48 | 20377248 | |
| 317 | Phosphorylation | SNNKSSLSLNSDLST CCCCCCEECCCCCCC | 27.70 | 22369663 | |
| 320 | Phosphorylation | KSSLSLNSDLSTPHF CCCEECCCCCCCCCH | 45.26 | 22369663 | |
| 323 | Phosphorylation | LSLNSDLSTPHFAKH EECCCCCCCCCHHHC | 44.90 | 22369663 | |
| 324 | Phosphorylation | SLNSDLSTPHFAKHS ECCCCCCCCCHHHCC | 28.25 | 22369663 | |
| 331 | Phosphorylation | TPHFAKHSPDSPRTS CCCHHHCCCCCCCCC | 29.69 | 20377248 | |
| 334 | Phosphorylation | FAKHSPDSPRTSRSF HHHCCCCCCCCCCCC | 21.48 | 19823750 | |
| 337 | Phosphorylation | HSPDSPRTSRSFNCG CCCCCCCCCCCCCCC | 31.69 | 20377248 | |
| 338 | Phosphorylation | SPDSPRTSRSFNCGD CCCCCCCCCCCCCCC | 27.49 | 19823750 | |
| 340 | Phosphorylation | DSPRTSRSFNCGDSQ CCCCCCCCCCCCCCC | 22.15 | 21440633 | |
| 346 | Phosphorylation | RSFNCGDSQSKVKLP CCCCCCCCCCCCCCC | 22.95 | 21440633 | |
| 348 | Phosphorylation | FNCGDSQSKVKLPEE CCCCCCCCCCCCCCC | 43.28 | 19779198 | |
| 359 | Phosphorylation | LPEENDASIAFSKMF CCCCCCCHHHHHHHH | 19.81 | 30377154 | |
| 363 | Phosphorylation | NDASIAFSKMFTRKR CCCHHHHHHHHCCCC | 17.75 | 30377154 | |
| 373 | Phosphorylation | FTRKRANTGGSTCSL HCCCCCCCCCCCCCC | 41.77 | 20377248 | |
| 376 | Phosphorylation | KRANTGGSTCSLASP CCCCCCCCCCCCCCH | 27.82 | 20377248 | |
| 377 | Phosphorylation | RANTGGSTCSLASPT CCCCCCCCCCCCCHH | 14.91 | 20377248 | |
| 379 | Phosphorylation | NTGGSTCSLASPTIA CCCCCCCCCCCHHHH | 27.36 | 20377248 | |
| 382 | Phosphorylation | GSTCSLASPTIAQTI CCCCCCCCHHHHHHH | 28.06 | 22369663 | |
| 384 | Phosphorylation | TCSLASPTIAQTIQQ CCCCCCHHHHHHHHH | 26.84 | 21440633 | |
| 388 | Phosphorylation | ASPTIAQTIQQSNIK CCHHHHHHHHHCCCC | 16.25 | 22369663 | |
| 392 | Phosphorylation | IAQTIQQSNIKVNKL HHHHHHHCCCCCCCC | 24.93 | 22369663 | |
| 404 | Phosphorylation | NKLPTQRTTSVGSLS CCCCCCCCCCCHHHH | 17.38 | 22369663 | |
| 405 | Phosphorylation | KLPTQRTTSVGSLSS CCCCCCCCCCHHHHH | 24.49 | 22369663 | |
| 406 | Phosphorylation | LPTQRTTSVGSLSSM CCCCCCCCCHHHHHH | 24.70 | 22369663 | |
| 409 | Phosphorylation | QRTTSVGSLSSMSNR CCCCCCHHHHHHCCC | 23.95 | 22369663 | |
| 411 | Phosphorylation | TTSVGSLSSMSNRYS CCCCHHHHHHCCCCC | 26.20 | 23749301 | |
| 412 | Phosphorylation | TSVGSLSSMSNRYSP CCCHHHHHHCCCCCC | 31.36 | 22369663 | |
| 414 | Phosphorylation | VGSLSSMSNRYSPIR CHHHHHHCCCCCCEE | 21.80 | 22369663 | |
| 417 | Phosphorylation | LSSMSNRYSPIRVAS HHHHCCCCCCEEECC | 24.05 | 22369663 | |
| 418 | Phosphorylation | SSMSNRYSPIRVASP HHHCCCCCCEEECCC | 15.60 | 22369663 | |
| 424 | Phosphorylation | YSPIRVASPGRARSA CCCEEECCCCCCCCC | 25.65 | 28889911 | |
| 430 | Phosphorylation | ASPGRARSATRGSSL CCCCCCCCCCCCHHH | 32.76 | 22369663 | |
| 432 | Phosphorylation | PGRARSATRGSSLYR CCCCCCCCCCHHHHH | 36.49 | 22369663 | |
| 435 | Phosphorylation | ARSATRGSSLYRLSR CCCCCCCHHHHHHHH | 17.55 | 22369663 | |
| 436 | Phosphorylation | RSATRGSSLYRLSRD CCCCCCHHHHHHHHC | 32.04 | 22369663 | |
| 438 | Phosphorylation | ATRGSSLYRLSRDLN CCCCHHHHHHHHCCC | 16.08 | 22369663 | |
| 446 | Phosphorylation | RLSRDLNSLPSVTDL HHHHCCCCCCCCCCC | 49.29 | 22369663 | |
| 449 | Phosphorylation | RDLNSLPSVTDLPEM HCCCCCCCCCCCCCC | 42.83 | 22369663 | |
| 451 | Phosphorylation | LNSLPSVTDLPEMDS CCCCCCCCCCCCCCC | 35.84 | 22369663 | |
| 458 | Phosphorylation | TDLPEMDSTTPVNEI CCCCCCCCCCCCCEE | 32.63 | 28132839 | |
| 459 | Phosphorylation | DLPEMDSTTPVNEIF CCCCCCCCCCCCEEE | 30.75 | 28132839 | |
| 460 | Phosphorylation | LPEMDSTTPVNEIFL CCCCCCCCCCCEEEC | 29.23 | 21440633 | |
| 475 | Phosphorylation | DGQPQHKSGSVKGGH CCCCCCCCCCCCCCC | 33.89 | 19823750 | |
| 477 | Phosphorylation | QPQHKSGSVKGGHRK CCCCCCCCCCCCCCC | 27.96 | 19823750 | |
| 488 | Phosphorylation | GHRKKQESISDAQRI CCCCCCCCCCHHHHH | 25.54 | 28132839 | |
| 571 | Phosphorylation | YSNENDASGEFSAFN HCCCCCCCCCCCCCC | 41.54 | 21551504 | |
| 679 | Phosphorylation | DKYTLVNTGLGLSDA CCEEEEECCCCCCCC | 26.72 | 22369663 | |
| 684 | Phosphorylation | VNTGLGLSDANLDHF EECCCCCCCCCHHHH | 32.64 | 22369663 | |
| 704 | Phosphorylation | KHASRSESNNNTGNR HHCCCCCCCCCCCCC | 46.21 | 21440633 | |
| 708 | Phosphorylation | RSESNNNTGNRVSYS CCCCCCCCCCCCEEC | 37.65 | 24961812 | |
| 713 | Phosphorylation | NNTGNRVSYSGSTPN CCCCCCCEECCCCCC | 15.45 | 23749301 | |
| 714 | Phosphorylation | NTGNRVSYSGSTPNN CCCCCCEECCCCCCC | 17.75 | 24961812 | |
| 715 | Phosphorylation | TGNRVSYSGSTPNNV CCCCCEECCCCCCCC | 20.82 | 28132839 | |
| 717 | Phosphorylation | NRVSYSGSTPNNVDT CCCEECCCCCCCCCC | 34.45 | 22369663 | |
| 718 | Phosphorylation | RVSYSGSTPNNVDTT CCEECCCCCCCCCCC | 33.29 | 22369663 | |
| 724 | Phosphorylation | STPNNVDTTKTNLQV CCCCCCCCCCCEEEE | 26.38 | 24961812 | |
| 725 | Phosphorylation | TPNNVDTTKTNLQVY CCCCCCCCCCEEEEE | 31.26 | 24961812 | |
| 757 | Phosphorylation | LLGEMGHSNNNSNSA HHHHCCCCCCCCCCC | 35.21 | 22369663 | |
| 761 | Phosphorylation | MGHSNNNSNSAINMN CCCCCCCCCCCCCCC | 33.99 | 22369663 | |
| 763 | Phosphorylation | HSNNNSNSAINMNEP CCCCCCCCCCCCCCC | 30.28 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BCK2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BCK2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BCK2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-757 ANDSER-761, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, AND MASSSPECTROMETRY. | |
