YAP6_YEAST - dbPTM
YAP6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YAP6_YEAST
UniProt AC Q03935
Protein Name AP-1-like transcription factor YAP6
Gene Name YAP6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 383
Subcellular Localization Nucleus .
Protein Description Transcription activator involved in the regulation of genes expressed in response to environmental changes and metabolic requirements. According to genome-wide promoter binding and gene expression studies it regulates, among others, genes involved in ribosome biogenesis, protein synthesis, carbohydrate metabolism, and carbohydrate transport. It may also be involved in pleiotropic drug resistance. When overexpressed, it confers resistance to cisplatin, methylmethanosulfonate, and mitomycin C, and increases cellular tolerance to sodium and lithium..
Protein Sequence MQNPPLIRPDMYNQGSSSMATYNASEKNLNEHPSPQIAQPSTSQKLPYRINPTTTNGDTDISVNSNPIQPPLPNLMHLSGPSDYRSMHQSPIHPSYIIPPHSNERKQSASYNRPQNAHVSIQPSVVFPPKSYSISYAPYQINPPLPNGLPNQSISLNKEYIAEEQLSTLPSRNTSVTTAPPSFQNSADTAKNSADNNDNNDNVTKPVPDKDTQLISSSGKTLRNTRRAAQNRTAQKAFRQRKEKYIKNLEQKSKIFDDLLAENNNFKSLNDSLRNDNNILIAQHEAIRNAITMLRSEYDVLCNENNMLKNENSIIKNEHNMSRNENENLKLENKRFHAEYIRMIEDIENTKRKEQEQRDEIEQLKKKIRSLEEIVGRHSDSAT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationPLIRPDMYNQGSSSM
CCCCCCCCCCCCCCC		16.2427017623
21PhosphorylationQGSSSMATYNASEKN
CCCCCCCCCCCCCCC		14.5227017623
22PhosphorylationGSSSMATYNASEKNL
CCCCCCCCCCCCCCC		10.1327017623
34PhosphorylationKNLNEHPSPQIAQPS
CCCCCCCCCCCCCCC		31.2019823750
108PhosphorylationHSNERKQSASYNRPQ
CCCCCCCCCCCCCCC		23.4029136822
110PhosphorylationNERKQSASYNRPQNA
CCCCCCCCCCCCCCC		28.3429136822
111PhosphorylationERKQSASYNRPQNAH
CCCCCCCCCCCCCCC		18.2029136822
120PhosphorylationRPQNAHVSIQPSVVF
CCCCCCEEECCEEEC		12.9729136822
124PhosphorylationAHVSIQPSVVFPPKS
CCEEECCEEECCCCC		17.9729136822
175PhosphorylationTLPSRNTSVTTAPPS
CCCCCCCCCCCCCCC		22.4827214570
370PhosphorylationQLKKKIRSLEEIVGR
HHHHHHHHHHHHHCC		43.5427214570
383PhosphorylationGRHSDSAT-------
CCCCCCCC-------		42.9923749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YAP6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YAP6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YAP6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG17_YEASTATG17physical
11283351
PHD1_YEASTPHD1genetic
19372386
AATC_YEASTAAT2genetic
20959818
IES1_YEASTIES1genetic
20959818
SUT1_YEASTSUT1genetic
20959818
UME6_YEASTUME6genetic
21127252
SPC72_YEASTSPC72physical
22875988
SPR3_YEASTSPR3physical
22875988
ETP1_YEASTETP1physical
22875988
NST1_YEASTNST1physical
22875988
RLF2_YEASTRLF2physical
22875988
RE107_YEASTREC107physical
22875988
THRC_YEASTTHR4genetic
27708008
ADY4_YEASTADY4genetic
27708008
PET8_YEASTPET8genetic
27708008
ELO2_YEASTELO2genetic
27708008
BUG1_YEASTBUG1genetic
27708008
GET3_YEASTGET3genetic
27708008
PEF1_YEASTPEF1genetic
27708008
DAL81_YEASTDAL81genetic
27708008
YJE3_YEASTYJL043Wgenetic
27708008
RL17B_YEASTRPL17Bgenetic
27708008
COX7_YEASTCOX7genetic
27708008
TMA23_YEASTTMA23genetic
27708008
SCS7_YEASTSCS7genetic
27708008
PUR1_YEASTADE4genetic
27708008
YNL5_YEASTYNL115Cgenetic
27708008
ADE_YEASTAAH1genetic
27708008
SWM2_YEASTSWM2genetic
27708008
YP260_YEASTYPL260Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YAP6_YEAST

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Related Literatures of Post-Translational Modification

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