| UniProt ID | BUG1_YEAST | |
|---|---|---|
| UniProt AC | Q12191 | |
| Protein Name | Binder of USO1 and GRH1 protein 1 | |
| Gene Name | BUG1 {ECO:0000303|PubMed:16269340} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 341 | |
| Subcellular Localization |
Cytoplasm. Golgi apparatus, cis-Golgi network membrane Peripheral membrane protein. Localizes to cytoplasm in a punctate pattern. Localizes to cis-Golgi together with GRH1. |
|
| Protein Description | Involved in ER to Golgi vesicle-mediated transport by either facilitating USO1-dependent and -independent tethering or increasing target accuracy of fusion events of COPII-coated vesicles.. | |
| Protein Sequence | MSEQESDEVKRMKQLEEARKRVEELKKKKNKKNKGKKNKNSSATGSIGSETPDLEGTPGEESTQEETVKANSTKSENNDQNDVDEESEEKEIEQVKSDPSGTTEKDIEEINSTSSNVGKDDAENTKKEEVQEVIKNNNDEQTADAGKTIEPQEEKKIVQTQEGNEPSNTSEAADDLFANDGNEESDFLTTIKKQKEEDELTKLRAENEKLTQENKQLKFLNMENETTVDDLQDQLQEKEDIINGLQNDLQTARDELIAAVEKLKLAEAKAARNTTATPIQFADFNTSSNNLTPSQSVTNSGTQVAHGNNMEVDRVMLNKWRQWNVDMTTWRSIGSGPIMEF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSEQESDEV ------CCHHHHHHH | 48.24 | 22814378 | |
| 2 | Phosphorylation | ------MSEQESDEV ------CCHHHHHHH | 48.24 | 22369663 | |
| 41 | Phosphorylation | KGKKNKNSSATGSIG CCCCCCCCCCCCCCC | 23.98 | 22369663 | |
| 42 | Phosphorylation | GKKNKNSSATGSIGS CCCCCCCCCCCCCCC | 38.96 | 22369663 | |
| 44 | Phosphorylation | KNKNSSATGSIGSET CCCCCCCCCCCCCCC | 33.15 | 22369663 | |
| 46 | Phosphorylation | KNSSATGSIGSETPD CCCCCCCCCCCCCCC | 21.30 | 22369663 | |
| 49 | Phosphorylation | SATGSIGSETPDLEG CCCCCCCCCCCCCCC | 36.31 | 22369663 | |
| 51 | Phosphorylation | TGSIGSETPDLEGTP CCCCCCCCCCCCCCC | 24.65 | 22369663 | |
| 57 | Phosphorylation | ETPDLEGTPGEESTQ CCCCCCCCCCCCCCH | 20.81 | 22369663 | |
| 62 | Phosphorylation | EGTPGEESTQEETVK CCCCCCCCCHHHHHH | 30.96 | 22369663 | |
| 63 | Phosphorylation | GTPGEESTQEETVKA CCCCCCCCHHHHHHC | 43.19 | 22369663 | |
| 67 | Phosphorylation | EESTQEETVKANSTK CCCCHHHHHHCCCCC | 26.93 | 22369663 | |
| 72 | Phosphorylation | EETVKANSTKSENND HHHHHCCCCCCCCCC | 41.91 | 28889911 | |
| 73 | Phosphorylation | ETVKANSTKSENNDQ HHHHCCCCCCCCCCC | 38.10 | 24961812 | |
| 75 | Phosphorylation | VKANSTKSENNDQND HHCCCCCCCCCCCCC | 45.72 | 22890988 | |
| 87 | Phosphorylation | QNDVDEESEEKEIEQ CCCCCHHHHHHHHHH | 49.35 | 22369663 | |
| 90 | Acetylation | VDEESEEKEIEQVKS CCHHHHHHHHHHHHC | 61.00 | 24489116 | |
| 97 | Phosphorylation | KEIEQVKSDPSGTTE HHHHHHHCCCCCCCH | 56.76 | 22369663 | |
| 100 | Phosphorylation | EQVKSDPSGTTEKDI HHHHCCCCCCCHHHH | 54.48 | 22369663 | |
| 102 | Phosphorylation | VKSDPSGTTEKDIEE HHCCCCCCCHHHHHH | 35.80 | 22369663 | |
| 103 | Phosphorylation | KSDPSGTTEKDIEEI HCCCCCCCHHHHHHH | 44.56 | 22369663 | |
| 112 | Phosphorylation | KDIEEINSTSSNVGK HHHHHHHHCCCCCCC | 35.01 | 22369663 | |
| 113 | Phosphorylation | DIEEINSTSSNVGKD HHHHHHHCCCCCCCC | 31.52 | 24909858 | |
| 114 | Phosphorylation | IEEINSTSSNVGKDD HHHHHHCCCCCCCCC | 21.53 | 20377248 | |
| 115 | Phosphorylation | EEINSTSSNVGKDDA HHHHHCCCCCCCCCC | 35.31 | 22369663 | |
| 125 | Phosphorylation | GKDDAENTKKEEVQE CCCCCHHCCHHHHHH | 34.69 | 22369663 | |
| 160 | Phosphorylation | EEKKIVQTQEGNEPS HHHHCEECCCCCCCC | 20.07 | 22369663 | |
| 167 | Phosphorylation | TQEGNEPSNTSEAAD CCCCCCCCCHHHHHH | 46.70 | 22369663 | |
| 169 | Phosphorylation | EGNEPSNTSEAADDL CCCCCCCHHHHHHHH | 32.08 | 22369663 | |
| 170 | Phosphorylation | GNEPSNTSEAADDLF CCCCCCHHHHHHHHH | 29.50 | 22369663 | |
| 185 | Phosphorylation | ANDGNEESDFLTTIK CCCCCCCHHHHHHHH | 27.73 | 20377248 | |
| 189 | Phosphorylation | NEESDFLTTIKKQKE CCCHHHHHHHHHHHH | 26.86 | 22369663 | |
| 190 | Phosphorylation | EESDFLTTIKKQKEE CCHHHHHHHHHHHHH | 32.71 | 22369663 | |
| 277 | Phosphorylation | AARNTTATPIQFADF HHCCCCCCCEEECCC | 20.87 | 23749301 | |
| 286 | Phosphorylation | IQFADFNTSSNNLTP EEECCCCCCCCCCCC | 33.26 | 27738172 | |
| 287 | Phosphorylation | QFADFNTSSNNLTPS EECCCCCCCCCCCCC | 31.97 | 24909858 | |
| 288 | Phosphorylation | FADFNTSSNNLTPSQ ECCCCCCCCCCCCCC | 27.91 | 19779198 | |
| 292 | Phosphorylation | NTSSNNLTPSQSVTN CCCCCCCCCCCEECC | 24.02 | 23749301 | |
| 294 | Phosphorylation | SSNNLTPSQSVTNSG CCCCCCCCCEECCCC | 29.83 | 28889911 | |
| 296 | Phosphorylation | NNLTPSQSVTNSGTQ CCCCCCCEECCCCCE | 34.93 | 19779198 | |
| 298 | Phosphorylation | LTPSQSVTNSGTQVA CCCCCEECCCCCEEE | 28.99 | 28889911 | |
| 300 | Phosphorylation | PSQSVTNSGTQVAHG CCCEECCCCCEEECC | 33.57 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BUG1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BUG1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BUG1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-57; SER-62; SER-87;SER-167; THR-169 AND SER-170, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87, AND MASSSPECTROMETRY. | |
