ARF2_YEAST - dbPTM
ARF2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARF2_YEAST
UniProt AC P19146
Protein Name ADP-ribosylation factor 2
Gene Name ARF2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 181
Subcellular Localization Golgi apparatus .
Protein Description GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus..
Protein Sequence MGLYASKLFSNLFGNKEMRILMVGLDGAGKTTVLYKLKLGEVITTIPTIGFNVETVQYKNISFTVWDVGGQDRIRSLWRHYYRNTEGVIFVIDSNDRSRIGEAREVMQRMLNEDELRNAVWLVFANKQDLPEAMSAAEITEKLGLHSIRNRPWFIQSTCATSGEGLYEGLEWLSNNLKNQS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2N-myristoyl glycine------MGLYASKLF
------CCHHHHHHH		27.65-
2Myristoylation------MGLYASKLF
------CCHHHHHHH		27.65-
10PhosphorylationLYASKLFSNLFGNKE
HHHHHHHHHHHCCCC		42.9621551504
16UbiquitinationFSNLFGNKEMRILMV
HHHHHCCCCEEEEEE		53.9523749301
362-HydroxyisobutyrylationGKTTVLYKLKLGEVI
CCEEEEEEEECCCEE		34.68-
127UbiquitinationVWLVFANKQDLPEAM
HHHEEECCCCHHHHH		41.5823749301
135PhosphorylationQDLPEAMSAAEITEK
CCHHHHHCHHHHHHH		31.2325752575
142UbiquitinationSAAEITEKLGLHSIR
CHHHHHHHHCCHHHC		38.9223749301
147PhosphorylationTEKLGLHSIRNRPWF
HHHHCCHHHCCCCEE		28.4322369663
178UbiquitinationEWLSNNLKNQS----
HHHHHHHCCCC----		55.8817644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARF2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARF2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARF2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GGA1_YEASTGGA1physical
12221117
GGA2_YEASTGGA2physical
12221117
ARF1_YEASTARF1genetic
16269340
BFR1_YEASTBFR1genetic
16269340
ATC3_YEASTDRS2genetic
16269340
HACD_YEASTPHS1genetic
16269340
BUG1_YEASTBUG1genetic
16269340
GOSR1_YEASTGOS1genetic
16269340
GET3_YEASTGET3genetic
16269340
ATC1_YEASTPMR1genetic
16269340
COPE_YEASTSEC28genetic
16269340
CWH41_YEASTCWH41genetic
16269340
GET2_YEASTGET2genetic
16269340
GET1_YEASTGET1genetic
16269340
COPB2_YEASTSEC27genetic
16269340
TVP15_YEASTTVP15physical
18467557
ARF1_YEASTARF1physical
18467557
ATG8_YEASTATG8genetic
20093466
AIM4_YEASTAIM4genetic
20093466
CHK1_YEASTCHK1genetic
20093466
STE50_YEASTSTE50genetic
20093466
FRM2_YEASTFRM2genetic
20093466
VPS41_YEASTVPS41genetic
20093466
SWI5_YEASTSWI5genetic
20093466
STP1_YEASTSTP1genetic
20093466
TPA1_YEASTTPA1genetic
20093466
RPOM_YEASTRPO41genetic
20093466
BLM10_YEASTBLM10genetic
20093466
YGZ2_YEASTYGL242Cgenetic
20093466
VAM7_YEASTVAM7genetic
20093466
STB5_YEASTSTB5genetic
20093466
THIK_YEASTPOT1genetic
20093466
HOC1_YEASTHOC1genetic
20093466
POC3_YEASTIRC25genetic
20093466
LEUR_YEASTLEU3genetic
20093466
YM79_YEASTYMR244Wgenetic
20093466
DSK2_YEASTDSK2genetic
20093466
PABC_YEASTABZ2genetic
20093466
SIW14_YEASTSIW14genetic
20093466
ATG3_YEASTATG3genetic
20093466
IZH4_YEASTIZH4genetic
20093466
AIM44_YEASTAIM44genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
GET2_YEASTGET2genetic
23891562
SRO7_YEASTSRO7genetic
23891562
MSMO_YEASTERG25genetic
23891562
CHK1_YEASTCHK1genetic
22282571
ATG8_YEASTATG8genetic
27708008
AIM4_YEASTAIM4genetic
27708008
STE50_YEASTSTE50genetic
27708008
SWI5_YEASTSWI5genetic
27708008
VPS74_YEASTVPS74genetic
27708008
STB5_YEASTSTB5genetic
27708008
THIK_YEASTPOT1genetic
27708008
LEUR_YEASTLEU3genetic
27708008
RS3A2_YEASTRPS1Bgenetic
27708008
GBLP_YEASTASC1genetic
27708008
YM79_YEASTYMR244Wgenetic
27708008
DSK2_YEASTDSK2genetic
27708008
SIW14_YEASTSIW14genetic
27708008
RRP6_YEASTRRP6genetic
27708008
LEE1_YEASTLEE1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARF2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-147, AND MASSSPECTROMETRY.

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