| UniProt ID | SWI5_YEAST | |
|---|---|---|
| UniProt AC | P08153 | |
| Protein Name | Transcriptional factor SWI5 | |
| Gene Name | SWI5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 709 | |
| Subcellular Localization | Nucleus . Cytoplasm . Nuclear in G1, cytoplasmic in S, G2 and M cell cycle phases. | |
| Protein Description | Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast. Recognizes a specific sequence in the promoter of the HO gene. Activates EGT2 transcription in a concentration-dependent manner. Synthesized during G2 and early mitosis.. | |
| Protein Sequence | MDTSNSWFDASKVQSLNFDLQTNSYYSNARGSDPSSYAIEGEYKTLATDDLGNILNLNYGETNEVIMNEINDLNLPLGPLSDEKSVKVSTFSELIGNDWQSMNFDLENNSREVTLNATSLLNENRLNQDSGMTVYQKTMSDKPHDEKKISMADNLLSTINKSEINKGFDRNLGELLLQQQQELREQLRAQQEANKKLELELKQTQYKQQQLQATLENSDGPQFLSPKRKISPASENVEDVYANSLSPMISPPMSNTSFTGSPSRRNNRQKYCLQRKNSSGTVGPLCFQELNEGFNDSLISPKKIRSNPNENLSSKTKFITPFTPKSRVSSATSNSANITPNNLRLDFKINVEDQESEYSEKPLGLGIELLGKPGPSPTKSVSLKSASVDIMPTIPGSVNNTPSVNKVSLSSSYIDQYTPRGKQLHFSSISENALGINAATPHLKPPSQQARHREGVFNDLDPNVLTKNTDNEGDDNEENEPESRFVISETPSPVLKSQSKYEGRSPQFGTHIKEINTYTTNSPSKITRKLTTLPRGSIDKYVKEMPDKTFECLFPGCTKTFKRRYNIRSHIQTHLEDRPYSCDHPGCDKAFVRNHDLIRHKKSHQEKAYACPCGKKFNREDALVVHRSRMICSGGKKYENVVIKRSPRKRGRPRKDGTSSVSSSPIKENINKDHNGQLMFKLEDQLRRERSYDGNGTGIMVSPMKTNQR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 32 | Phosphorylation | YYSNARGSDPSSYAI CCCCCCCCCCHHCEE | 40.57 | 27017623 | |
| 150 | Phosphorylation | PHDEKKISMADNLLS CCCHHHHHHHHHHHH | 19.46 | 21551504 | |
| 158 | Phosphorylation | MADNLLSTINKSEIN HHHHHHHHCCHHHHH | 28.65 | 21551504 | |
| 161 | Acetylation | NLLSTINKSEINKGF HHHHHCCHHHHHHCC | 45.69 | 17397211 | |
| 162 | Phosphorylation | LLSTINKSEINKGFD HHHHCCHHHHHHCCC | 38.94 | 21551504 | |
| 218 | Phosphorylation | LQATLENSDGPQFLS HHHHHHCCCCCCCCC | 34.27 | 24961812 | |
| 225 | Phosphorylation | SDGPQFLSPKRKISP CCCCCCCCCCCCCCC | 29.66 | 22369663 | |
| 227 | Ubiquitination | GPQFLSPKRKISPAS CCCCCCCCCCCCCCC | 64.05 | 23749301 | |
| 244 | Phosphorylation | VEDVYANSLSPMISP HHHHHHHCCCCCCCC | 23.27 | 19779198 | |
| 246 | Phosphorylation | DVYANSLSPMISPPM HHHHHCCCCCCCCCC | 16.55 | 19779198 | |
| 250 | Phosphorylation | NSLSPMISPPMSNTS HCCCCCCCCCCCCCC | 19.39 | 28889911 | |
| 254 | Phosphorylation | PMISPPMSNTSFTGS CCCCCCCCCCCCCCC | 42.61 | 21440633 | |
| 257 | Phosphorylation | SPPMSNTSFTGSPSR CCCCCCCCCCCCCCC | 25.68 | 21440633 | |
| 259 | Phosphorylation | PMSNTSFTGSPSRRN CCCCCCCCCCCCCCC | 36.20 | 19779198 | |
| 261 | Phosphorylation | SNTSFTGSPSRRNNR CCCCCCCCCCCCCCC | 19.35 | 23749301 | |
| 263 | Phosphorylation | TSFTGSPSRRNNRQK CCCCCCCCCCCCCHH | 45.64 | 27738172 | |
| 278 | Phosphorylation | YCLQRKNSSGTVGPL EEEECCCCCCCCCCH | 32.93 | 22369663 | |
| 279 | Phosphorylation | CLQRKNSSGTVGPLC EEECCCCCCCCCCHH | 48.12 | 22369663 | |
| 281 | Phosphorylation | QRKNSSGTVGPLCFQ ECCCCCCCCCCHHHH | 25.00 | 22369663 | |
| 297 | Phosphorylation | LNEGFNDSLISPKKI HHCCCCCCCCCHHHH | 28.80 | 22369663 | |
| 300 | Phosphorylation | GFNDSLISPKKIRSN CCCCCCCCHHHHCCC | 35.64 | 22369663 | |
| 316 | Phosphorylation | NENLSSKTKFITPFT CCCCCCCCCEECCCC | 32.89 | 28889911 | |
| 323 | Phosphorylation | TKFITPFTPKSRVSS CCEECCCCCHHHCCC | 30.89 | 21440633 | |
| 329 | Phosphorylation | FTPKSRVSSATSNSA CCCHHHCCCCCCCCC | 17.10 | 28889911 | |
| 330 | Phosphorylation | TPKSRVSSATSNSAN CCHHHCCCCCCCCCC | 32.48 | 19779198 | |
| 332 | Phosphorylation | KSRVSSATSNSANIT HHHCCCCCCCCCCCC | 30.32 | 23749301 | |
| 333 | Phosphorylation | SRVSSATSNSANITP HHCCCCCCCCCCCCC | 28.62 | 21440633 | |
| 335 | Phosphorylation | VSSATSNSANITPNN CCCCCCCCCCCCCCC | 23.59 | 23749301 | |
| 339 | Phosphorylation | TSNSANITPNNLRLD CCCCCCCCCCCEEEE | 21.55 | 21440633 | |
| 348 | Ubiquitination | NNLRLDFKINVEDQE CCEEEEEEEECCCCC | 32.79 | 17644757 | |
| 356 | Phosphorylation | INVEDQESEYSEKPL EECCCCCCHHCCCCC | 35.88 | 22369663 | |
| 358 | Phosphorylation | VEDQESEYSEKPLGL CCCCCCHHCCCCCCE | 31.26 | 22369663 | |
| 359 | Phosphorylation | EDQESEYSEKPLGLG CCCCCHHCCCCCCEE | 34.78 | 22369663 | |
| 361 | Ubiquitination | QESEYSEKPLGLGIE CCCHHCCCCCCEEEE | 39.33 | 17644757 | |
| 372 | Ubiquitination | LGIELLGKPGPSPTK EEEEECCCCCCCCCC | 46.93 | 17644757 | |
| 376 | Phosphorylation | LLGKPGPSPTKSVSL ECCCCCCCCCCCCCC | 51.63 | 22369663 | |
| 378 | Phosphorylation | GKPGPSPTKSVSLKS CCCCCCCCCCCCCCC | 40.05 | 22369663 | |
| 379 | Ubiquitination | KPGPSPTKSVSLKSA CCCCCCCCCCCCCCC | 52.85 | 17644757 | |
| 380 | Phosphorylation | PGPSPTKSVSLKSAS CCCCCCCCCCCCCCC | 21.29 | 28889911 | |
| 384 | Ubiquitination | PTKSVSLKSASVDIM CCCCCCCCCCCEEEC | 36.15 | 17644757 | |
| 393 | Phosphorylation | ASVDIMPTIPGSVNN CCEEECCCCCCCCCC | 23.56 | 24961812 | |
| 397 | Phosphorylation | IMPTIPGSVNNTPSV ECCCCCCCCCCCCCC | 19.13 | 19684113 | |
| 401 | Phosphorylation | IPGSVNNTPSVNKVS CCCCCCCCCCCCEEE | 16.25 | 19684113 | |
| 403 | Phosphorylation | GSVNNTPSVNKVSLS CCCCCCCCCCEEECC | 35.96 | 21440633 | |
| 406 | Ubiquitination | NNTPSVNKVSLSSSY CCCCCCCEEECCCHH | 30.92 | 17644757 | |
| 410 | Phosphorylation | SVNKVSLSSSYIDQY CCCEEECCCHHHCCC | 15.10 | 19779198 | |
| 411 | Phosphorylation | VNKVSLSSSYIDQYT CCEEECCCHHHCCCC | 32.24 | 19779198 | |
| 412 | Phosphorylation | NKVSLSSSYIDQYTP CEEECCCHHHCCCCC | 23.80 | 29688323 | |
| 413 | Phosphorylation | KVSLSSSYIDQYTPR EEECCCHHHCCCCCC | 15.51 | 29688323 | |
| 417 | Phosphorylation | SSSYIDQYTPRGKQL CCHHHCCCCCCCCEE | 18.24 | 21440633 | |
| 418 | Phosphorylation | SSYIDQYTPRGKQLH CHHHCCCCCCCCEEE | 10.81 | 22369663 | |
| 469 | Phosphorylation | PNVLTKNTDNEGDDN HHHCCCCCCCCCCCC | 41.58 | 19823750 | |
| 483 | Phosphorylation | NEENEPESRFVISET CCCCCCCCCEEEECC | 41.56 | 24961812 | |
| 488 | Phosphorylation | PESRFVISETPSPVL CCCCEEEECCCCCHH | 30.07 | 22369663 | |
| 490 | Phosphorylation | SRFVISETPSPVLKS CCEEEECCCCCHHCC | 23.44 | 22369663 | |
| 492 | Phosphorylation | FVISETPSPVLKSQS EEEECCCCCHHCCCC | 34.75 | 22369663 | |
| 496 | Ubiquitination | ETPSPVLKSQSKYEG CCCCCHHCCCCCCCC | 46.84 | 17644757 | |
| 501 | Phosphorylation | VLKSQSKYEGRSPQF HHCCCCCCCCCCCCC | 28.94 | 22369663 | |
| 505 | Phosphorylation | QSKYEGRSPQFGTHI CCCCCCCCCCCCCCE | 33.63 | 22369663 | |
| 510 | Phosphorylation | GRSPQFGTHIKEINT CCCCCCCCCEEEEEE | 23.01 | 22369663 | |
| 517 | Phosphorylation | THIKEINTYTTNSPS CCEEEEEEEECCCCC | 28.10 | 22890988 | |
| 518 | Phosphorylation | HIKEINTYTTNSPSK CEEEEEEEECCCCCH | 13.69 | 22890988 | |
| 519 | Phosphorylation | IKEINTYTTNSPSKI EEEEEEEECCCCCHH | 19.91 | 22890988 | |
| 520 | Phosphorylation | KEINTYTTNSPSKIT EEEEEEECCCCCHHC | 24.24 | 22890988 | |
| 522 | Phosphorylation | INTYTTNSPSKITRK EEEEECCCCCHHCHH | 28.58 | 22369663 | |
| 524 | Phosphorylation | TYTTNSPSKITRKLT EEECCCCCHHCHHHH | 36.19 | 22890988 | |
| 531 | Phosphorylation | SKITRKLTTLPRGSI CHHCHHHHCCCCCCH | 29.35 | 19779198 | |
| 644 | Ubiquitination | KYENVVIKRSPRKRG EEEEEEECCCCCCCC | 34.90 | 23749301 | |
| 646 | Phosphorylation | ENVVIKRSPRKRGRP EEEEECCCCCCCCCC | 24.85 | 17287358 | |
| 655 | Ubiquitination | RKRGRPRKDGTSSVS CCCCCCCCCCCCCCC | 64.29 | 17644757 | |
| 658 | Phosphorylation | GRPRKDGTSSVSSSP CCCCCCCCCCCCCCC | 28.14 | 22369663 | |
| 659 | Phosphorylation | RPRKDGTSSVSSSPI CCCCCCCCCCCCCCC | 33.98 | 22369663 | |
| 660 | Phosphorylation | PRKDGTSSVSSSPIK CCCCCCCCCCCCCCC | 26.34 | 22369663 | |
| 662 | Phosphorylation | KDGTSSVSSSPIKEN CCCCCCCCCCCCCCC | 27.35 | 22369663 | |
| 663 | Phosphorylation | DGTSSVSSSPIKENI CCCCCCCCCCCCCCC | 37.67 | 22369663 | |
| 664 | Phosphorylation | GTSSVSSSPIKENIN CCCCCCCCCCCCCCC | 24.12 | 22369663 | |
| 667 | Ubiquitination | SVSSSPIKENINKDH CCCCCCCCCCCCCCC | 48.36 | 17644757 | |
| 672 | Ubiquitination | PIKENINKDHNGQLM CCCCCCCCCCCCCEE | 57.47 | 17644757 | |
| 691 | Phosphorylation | DQLRRERSYDGNGTG HHHHHHCCCCCCCCC | 23.87 | 22369663 | |
| 692 | Phosphorylation | QLRRERSYDGNGTGI HHHHHCCCCCCCCCE | 33.81 | 22369663 | |
| 697 | Phosphorylation | RSYDGNGTGIMVSPM CCCCCCCCCEEECCC | 27.77 | 23749301 | |
| 702 | Phosphorylation | NGTGIMVSPMKTNQR CCCCEEECCCCCCCC | 11.25 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 522 | S | Phosphorylation | Kinase | CDC28 | P00546 | Uniprot |
| 522 | S | Phosphorylation | Kinase | CDK-FAMILY | - | GPS |
| 522 | S | Phosphorylation | Kinase | CDK_GROUP | - | PhosphoELM |
| 646 | S | Phosphorylation | Kinase | CDC28 | P00546 | Uniprot |
| 646 | S | Phosphorylation | Kinase | CDK-FAMILY | - | GPS |
| 646 | S | Phosphorylation | Kinase | CDK_GROUP | - | PhosphoELM |
| 664 | S | Phosphorylation | Kinase | CDC28 | P00546 | Uniprot |
| 664 | S | Phosphorylation | Kinase | CDK-FAMILY | - | GPS |
| 664 | S | Phosphorylation | Kinase | CDK_GROUP | - | PhosphoELM |
| - | K | Ubiquitination | E3 ubiquitin ligase | CDC4 | P07834 | PMID:22199232 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SWI5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SWI5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-492 AND SER-505, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278 AND SER-505, ANDMASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-505 AND SER-646, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-492, AND MASSSPECTROMETRY. | |
