| UniProt ID | INP53_YEAST | |
|---|---|---|
| UniProt AC | Q12271 | |
| Protein Name | Polyphosphatidylinositol phosphatase INP53 | |
| Gene Name | INP53 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1107 | |
| Subcellular Localization | Cytoplasm . Cytoplasmic punctate structures. Hyperosmotic stress causes translocation to actin patches. | |
| Protein Description | Dephosphorylates a number of phosphatidylinositols (PIs) like phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), but also phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Plays an essential role in a TGN (trans Golgi network)-to-early endosome pathway. Involved in clathrin-mediated protein sorting at the TGN.. | |
| Protein Sequence | MIIFVSEEPERRLAIVSNLYALVLKPVGKKPSDKPLCAIELLQKNDLKKYGFKRLTSHEIFGVIGLIEVNGLLFVGAITGKSKVAQPCPGETVNKIFAVDFFCLNDNSWDFIEIDSSGYPVLPETASTEYQDALPKHPCYELKKLLSNGSFYYSSDFDLTSTLQHRGYGQHSLSTDTYEEEYMWNSFLMQEMITYRDHLDTNLKQILDDEGFLTTVIRGFAETFVSYVKKLKVALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFIMYSSQYCYAFTQIRGSIPVFWEQGTSLINPRVQITRSFEATQPVFDKHIMKSVEKYGPVHVVNLLSTKSSEIELSKRYKEHLTHSKKLNFNKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSLLSSGYYSYDVREKKNISEQHGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTLWADHGDQISQIYTGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDTLLGRLPYQKAVQLYDPVNEYVSTKLQSMSDKFTSTSNINLLIGSFNVNGATKKVDLSKWLFPIGEKFKPDIVVLGLQEVIELSAGSILNADYSKSSFWENLVGDCLNQYDDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATKKTGFRGMAGNKGAVSIRFEYGATSFCFVNSHLAAGATNVEERRSDYESIVRGITFTRTKMIPHHDSIFWLGDMNYRINLPNEDVRRELLNQEEGYIDKLLHFDQLTLGINSGSVFEGFKEPTLKFRPTYKYDPGTGTYDSSEKERTPSWTDRIIYKGENLLPLSYSDAPIMISDHRPVYAAYRAKITFVDDKERLSLKKRLFTEYKQEHPEEPGSLISDLLSLDLDNKSTDGFKSSSESSLLDIDPIMAQPTASSVASSSPVSSASASLQPVRTQNSSQSRTPIKKPVLRPPPPPAHKSVSAPAPSTSKEKSPTPQTSTASLSSVTKNIQENKPLAQNRRIPPPGFSQNILTPKSTSNLASPMSSKVDLYNSASESTRSAQDARQQTPTAFAASRDVNGQPEALLGDENPIEPEEKAKLNHMTLDSWQPLTPK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 83 | Ubiquitination | GAITGKSKVAQPCPG EEECCCCCCCCCCCC | 45.11 | 23749301 | |
| 168 | Phosphorylation | STLQHRGYGQHSLST CCCCCCCCCCCCCCC | 17.36 | 27017623 | |
| 172 | Phosphorylation | HRGYGQHSLSTDTYE CCCCCCCCCCCCCCC | 19.00 | 27017623 | |
| 174 | Phosphorylation | GYGQHSLSTDTYEEE CCCCCCCCCCCCCHH | 27.53 | 27017623 | |
| 182 | Phosphorylation | TDTYEEEYMWNSFLM CCCCCHHHHHHHHHH | 15.65 | 27017623 | |
| 195 | Phosphorylation | LMQEMITYRDHLDTN HHHHHHHHHHHHCCC | 11.79 | 27017623 | |
| 317 | Acetylation | ATQPVFDKHIMKSVE CCCHHCCHHHHHHHH | 24.46 | 24489116 | |
| 325 | Ubiquitination | HIMKSVEKYGPVHVV HHHHHHHHHCCEEEE | 54.04 | 17644757 | |
| 338 | Ubiquitination | VVNLLSTKSSEIELS EEEEECCCCCHHHHH | 48.92 | 17644757 | |
| 340 | Phosphorylation | NLLSTKSSEIELSKR EEECCCCCHHHHHHH | 44.12 | 28889911 | |
| 411 | Phosphorylation | VREKKNISEQHGIFR HHHCCCHHHHCCCCH | 40.37 | 25704821 | |
| 419 | Phosphorylation | EQHGIFRTNCLDCLD HHCCCCHHCHHHHHC | 21.38 | 17563356 | |
| 454 | Phosphorylation | FRLISSNSFIDDDDF HCHHCCCCCCCCHHH | 26.06 | 30377154 | |
| 467 | Phosphorylation | DFVSKHNTLWADHGD HHHHHCCEEEECCCH | 24.32 | 22369663 | |
| 477 | Phosphorylation | ADHGDQISQIYTGTN ECCCHHCCEECCCCH | 12.61 | 22369663 | |
| 480 | Phosphorylation | GDQISQIYTGTNALK CHHCCEECCCCHHHH | 7.47 | 22369663 | |
| 481 | Phosphorylation | DQISQIYTGTNALKS HHCCEECCCCHHHHH | 38.88 | 22369663 | |
| 483 | Phosphorylation | ISQIYTGTNALKSSF CCEECCCCHHHHHCC | 14.98 | 22369663 | |
| 488 | Phosphorylation | TGTNALKSSFSRKGK CCCHHHHHCCCCCCC | 37.15 | 22369663 | |
| 489 | Phosphorylation | GTNALKSSFSRKGKM CCHHHHHCCCCCCCC | 26.17 | 22369663 | |
| 491 | Phosphorylation | NALKSSFSRKGKMSL HHHHHCCCCCCCCCH | 34.72 | 22369663 | |
| 497 | Phosphorylation | FSRKGKMSLAGALSD CCCCCCCCHHHHHHH | 20.67 | 27017623 | |
| 507 | Ubiquitination | GALSDATKSVSRIYI HHHHHHCHHCHHHHH | 51.05 | 24961812 | |
| 508 | Phosphorylation | ALSDATKSVSRIYIN HHHHHCHHCHHHHHH | 22.44 | 21440633 | |
| 510 | Phosphorylation | SDATKSVSRIYINNF HHHCHHCHHHHHHCC | 21.76 | 21440633 | |
| 520 | Acetylation | YINNFMDKEKQQNID HHHCCCCHHHHCCHH | 55.83 | 24489116 | |
| 673 | Phosphorylation | VKQVEGATKKTGFRG HHHHCCCCCCCCCCC | 43.88 | 24930733 | |
| 804 | Acetylation | LKFRPTYKYDPGTGT CEECCCEEECCCCCC | 45.73 | 24489116 | |
| 805 | Phosphorylation | KFRPTYKYDPGTGTY EECCCEEECCCCCCC | 19.56 | 27214570 | |
| 811 | Phosphorylation | KYDPGTGTYDSSEKE EECCCCCCCCCCCCC | 24.80 | 27214570 | |
| 815 | Phosphorylation | GTGTYDSSEKERTPS CCCCCCCCCCCCCCC | 50.19 | 27214570 | |
| 817 | Ubiquitination | GTYDSSEKERTPSWT CCCCCCCCCCCCCCC | 55.21 | 23749301 | |
| 889 | Phosphorylation | EHPEEPGSLISDLLS HCCCCCCCHHHHHHC | 32.99 | 22369663 | |
| 892 | Phosphorylation | EEPGSLISDLLSLDL CCCCCHHHHHHCCCC | 27.74 | 22369663 | |
| 896 | Phosphorylation | SLISDLLSLDLDNKS CHHHHHHCCCCCCCC | 27.43 | 22369663 | |
| 903 | Phosphorylation | SLDLDNKSTDGFKSS CCCCCCCCCCCCCCC | 37.68 | 22369663 | |
| 904 | Phosphorylation | LDLDNKSTDGFKSSS CCCCCCCCCCCCCCC | 41.57 | 22369663 | |
| 913 | Phosphorylation | GFKSSSESSLLDIDP CCCCCCHHHCCCCCC | 28.38 | 19779198 | |
| 914 | Phosphorylation | FKSSSESSLLDIDPI CCCCCHHHCCCCCCC | 28.97 | 19779198 | |
| 926 | Phosphorylation | DPIMAQPTASSVASS CCCCCCCCCHHHCCC | 27.39 | 30377154 | |
| 932 | Phosphorylation | PTASSVASSSPVSSA CCCHHHCCCCCCCCC | 29.23 | 28889911 | |
| 933 | Phosphorylation | TASSVASSSPVSSAS CCHHHCCCCCCCCCC | 28.99 | 28889911 | |
| 934 | Phosphorylation | ASSVASSSPVSSASA CHHHCCCCCCCCCCC | 27.16 | 25752575 | |
| 937 | Phosphorylation | VASSSPVSSASASLQ HCCCCCCCCCCCCCC | 24.46 | 27738172 | |
| 938 | Phosphorylation | ASSSPVSSASASLQP CCCCCCCCCCCCCCC | 26.86 | 30377154 | |
| 956 | Phosphorylation | QNSSQSRTPIKKPVL CCCCCCCCCCCCCCC | 34.31 | 23749301 | |
| 973 | Phosphorylation | PPPPAHKSVSAPAPS CCCCCCCCCCCCCCC | 16.07 | 22369663 | |
| 975 | Phosphorylation | PPAHKSVSAPAPSTS CCCCCCCCCCCCCCC | 35.31 | 22369663 | |
| 980 | Phosphorylation | SVSAPAPSTSKEKSP CCCCCCCCCCCCCCC | 47.63 | 22369663 | |
| 981 | Phosphorylation | VSAPAPSTSKEKSPT CCCCCCCCCCCCCCC | 42.64 | 22369663 | |
| 982 | Phosphorylation | SAPAPSTSKEKSPTP CCCCCCCCCCCCCCC | 43.06 | 21440633 | |
| 985 | Ubiquitination | APSTSKEKSPTPQTS CCCCCCCCCCCCCCC | 66.52 | 23749301 | |
| 986 | Phosphorylation | PSTSKEKSPTPQTST CCCCCCCCCCCCCCC | 34.79 | 22369663 | |
| 988 | Phosphorylation | TSKEKSPTPQTSTAS CCCCCCCCCCCCCCC | 34.81 | 22369663 | |
| 991 | Phosphorylation | EKSPTPQTSTASLSS CCCCCCCCCCCCHHH | 29.28 | 22369663 | |
| 992 | Phosphorylation | KSPTPQTSTASLSSV CCCCCCCCCCCHHHH | 19.41 | 22369663 | |
| 993 | Phosphorylation | SPTPQTSTASLSSVT CCCCCCCCCCHHHHH | 24.53 | 22369663 | |
| 995 | Phosphorylation | TPQTSTASLSSVTKN CCCCCCCCHHHHHHC | 28.95 | 22369663 | |
| 997 | Phosphorylation | QTSTASLSSVTKNIQ CCCCCCHHHHHHCHH | 21.92 | 22369663 | |
| 998 | Phosphorylation | TSTASLSSVTKNIQE CCCCCHHHHHHCHHH | 38.81 | 22369663 | |
| 1000 | Phosphorylation | TASLSSVTKNIQENK CCCHHHHHHCHHHCC | 21.96 | 22369663 | |
| 1007 | Ubiquitination | TKNIQENKPLAQNRR HHCHHHCCCCCCCCC | 40.43 | 23749301 | |
| 1021 | Phosphorylation | RIPPPGFSQNILTPK CCCCCCCCCCCCCCC | 28.38 | 30377154 | |
| 1026 | Phosphorylation | GFSQNILTPKSTSNL CCCCCCCCCCCCCCC | 25.52 | 21440633 | |
| 1029 | Phosphorylation | QNILTPKSTSNLASP CCCCCCCCCCCCCCC | 37.97 | 22369663 | |
| 1030 | Phosphorylation | NILTPKSTSNLASPM CCCCCCCCCCCCCCC | 27.97 | 22369663 | |
| 1031 | Phosphorylation | ILTPKSTSNLASPMS CCCCCCCCCCCCCCC | 36.62 | 22369663 | |
| 1035 | Phosphorylation | KSTSNLASPMSSKVD CCCCCCCCCCCCCHH | 25.05 | 22369663 | |
| 1038 | Phosphorylation | SNLASPMSSKVDLYN CCCCCCCCCCHHHHC | 30.32 | 22369663 | |
| 1039 | Phosphorylation | NLASPMSSKVDLYNS CCCCCCCCCHHHHCC | 30.37 | 22369663 | |
| 1040 | Ubiquitination | LASPMSSKVDLYNSA CCCCCCCCHHHHCCC | 32.25 | 24961812 | |
| 1044 | Phosphorylation | MSSKVDLYNSASEST CCCCHHHHCCCCHHH | 11.56 | 22369663 | |
| 1046 | Phosphorylation | SKVDLYNSASESTRS CCHHHHCCCCHHHHH | 21.44 | 22369663 | |
| 1048 | Phosphorylation | VDLYNSASESTRSAQ HHHHCCCCHHHHHHH | 31.72 | 22369663 | |
| 1050 | Phosphorylation | LYNSASESTRSAQDA HHCCCCHHHHHHHHH | 26.99 | 23749301 | |
| 1051 | Phosphorylation | YNSASESTRSAQDAR HCCCCHHHHHHHHHH | 25.29 | 22369663 | |
| 1053 | Phosphorylation | SASESTRSAQDARQQ CCCHHHHHHHHHHHH | 30.30 | 22369663 | |
| 1061 | Phosphorylation | AQDARQQTPTAFAAS HHHHHHHCCCCHHHC | 17.80 | 22369663 | |
| 1063 | Phosphorylation | DARQQTPTAFAASRD HHHHHCCCCHHHCCC | 37.48 | 29734811 | |
| 1068 | Phosphorylation | TPTAFAASRDVNGQP CCCCHHHCCCCCCCC | 26.11 | 29688323 | |
| 1105 | Phosphorylation | LDSWQPLTPK----- CCCCCCCCCC----- | 35.40 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of INP53_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of INP53_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of INP53_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-903; SER-932; SER-933;SER-934; SER-975; SER-986; THR-988; SER-1029; THR-1030; SER-1031;SER-1035; SER-1039 AND THR-1061, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-986, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1105, AND MASSSPECTROMETRY. | |
