DCE_YEAST - dbPTM
DCE_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DCE_YEAST
UniProt AC Q04792
Protein Name Glutamate decarboxylase
Gene Name GAD1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 585
Subcellular Localization
Protein Description
Protein Sequence MLHRHGSKQKNFENIAGKVVHDLAGLQLLSNDVQKSAVQSGHQGSNNMRDTSSQGMANKYSVPKKGLPADLSYQLIHNELTLDGNPHLNLASFVNTFTTDQARKLIDENLTKNLADNDEYPQLIELTQRCISMLAQLWHANPDEEPIGCATTGSSEAIMLGGLAMKKRWEHRMKNAGKDASKPNIIMSSACQVALEKFTRYFEVECRLVPVSHRSHHMLDPESLWDYVDENTIGCFVILGTTYTGHLENVEKVADVLSQIEAKHPDWSNTDIPIHADGASGGFIIPFGFEKEHMKAYGMERWGFNHPRVVSMNTSGHKFGLTTPGLGWVLWRDESLLADELRFKLKYLGGVEETFGLNFSRPGFQVVHQYFNFVSLGHSGYRTQFQNSLFVARAFSFELLNSSKLPGCFEIVSSIHESIENDSAPKSVKDYWEHPQAYKPGVPLVAFKLSKKFHEEYPEVPQAILSSLLRGRGWIIPNYPLPKATDGSDEKEVLRVVFRSEMKLDLAQLLIVDIESILTKLIHSYEKVCHHIELASEQTPERKSSFIYEMLLALASPQDDIPTPDEIEKKNKLKETTTRNYRGTC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
30PhosphorylationLAGLQLLSNDVQKSA
HHHHHHHCCHHHHHH		39.3121440633
36PhosphorylationLSNDVQKSAVQSGHQ
HCCHHHHHHHHHCCC		19.3128889911
40PhosphorylationVQKSAVQSGHQGSNN
HHHHHHHHCCCCCCC		31.4828889911
45PhosphorylationVQSGHQGSNNMRDTS
HHHCCCCCCCCCCCC		20.6128889911
51PhosphorylationGSNNMRDTSSQGMAN
CCCCCCCCCCCCCCC		21.6622369663
52PhosphorylationSNNMRDTSSQGMANK
CCCCCCCCCCCCCCC		25.5922369663
53PhosphorylationNNMRDTSSQGMANKY
CCCCCCCCCCCCCCC		32.6122369663
104UbiquitinationFTTDQARKLIDENLT
CCHHHHHHHHCCCHH		53.4623749301
188PhosphorylationSKPNIIMSSACQVAL
CCCCEEECHHHHHHH		12.3630377154
258PhosphorylationEKVADVLSQIEAKHP
HHHHHHHHHHHHHCC		29.0328889911
318N6-(pyridoxal phosphate)lysineSMNTSGHKFGLTTPG
EEECCCCCCCCCCCC		44.65-
318OtherSMNTSGHKFGLTTPG
EEECCCCCCCCCCCC		44.65-
335PhosphorylationWVLWRDESLLADELR
EEEECCHHHHHHHHH		32.7330377154
479PhosphorylationRGWIIPNYPLPKATD
CCCCCCCCCCCCCCC		10.7828889911
491AcetylationATDGSDEKEVLRVVF
CCCCCCHHHHHHHHH		59.1024489116
539PhosphorylationIELASEQTPERKSSF
HHHHCCCCCCHHHHH		24.0621440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DCE_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DCE_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DCE_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DCE_YEASTGAD1physical
18467557
IDH1_YEASTIDH1genetic
21623372
COX5A_YEASTCOX5Agenetic
21623372
DCE_YEASTGAD1physical
22615397
GABAT_YEASTUGA1genetic
23447388
UGA2_YEASTUGA2genetic
23447388
CSN12_YEASTYJR084Wgenetic
27708008
EIF3J_YEASTHCR1genetic
27708008
INO4_YEASTINO4genetic
27708008
VAM3_YEASTVAM3genetic
27708008
UBA3_YEASTUBA3genetic
27708008
ATG15_YEASTATG15genetic
27708008
CYPR_YEASTCPR4genetic
27708008
SLX5_YEASTSLX5genetic
27708008
SWF1_YEASTSWF1genetic
27708008
CWC15_YEASTCWC15genetic
27708008
PEX10_YEASTPEX10genetic
27708008
SLX8_YEASTSLX8genetic
27708008
YHK5_YEASTYHR045Wgenetic
27708008
SSF1_YEASTSSF1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
ASF1_YEASTASF1genetic
27708008
PET10_YEASTPET10genetic
27708008
TAL1_YEASTTAL1genetic
27708008
PHO23_YEASTPHO23genetic
27708008
ATG3_YEASTATG3genetic
27708008
GYP1_YEASTGYP1genetic
27708008
SUCA_YEASTLSC1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DCE_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258, AND MASSSPECTROMETRY.

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