| UniProt ID | GYP1_YEAST | |
|---|---|---|
| UniProt AC | Q08484 | |
| Protein Name | GTPase-activating protein GYP1 | |
| Gene Name | GYP1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 637 | |
| Subcellular Localization | Golgi apparatus, Golgi stack . | |
| Protein Description | Stimulates specifically the GTPase activity of YPT1. Functions on the Golgi as a negative regulator of YPT1.. | |
| Protein Sequence | MGVRSAAKEMHERDHNSDSSSLVTSLMKSWRISSASSSKKPSLYKMNTTESTSLPSGYASSADRDRRTSDGNFEAMAKQQASTRRTSNSYSPLRYVNPTLSTASNESPRPALLLRQHHQRHHHHQQPRHSSSGSVGNNCSNSTEPNKKGDRYFKDLDEDWSAVIDDYNMPIPILTNGGFGTPVAPTRTLSRKSTSSSINSISNMGTSAVRNSSSSFTYPQLPQLQKEKTNDSKKTQLEIENERDVQELNSIIQRISKFDNILKDKTIINQQDLRQISWNGIPKIHRPVVWKLLIGYLPVNTKRQEGFLQRKRKEYRDSLKHTFSDQHSRDIPTWHQIEIDIPRTNPHIPLYQFKSVQNSLQRILYLWAIRHPASGYVQGINDLVTPFFETFLTEYLPPSQIDDVEIKDPSTYMVDEQITDLEADTFWCLTKLLEQITDNYIHGQPGILRQVKNLSQLVKRIDADLYNHFQNEHVEFIQFAFRWMNCLLMREFQMGTVIRMWDTYLSETSQEVTSSYSMSSNDIKPPVTPTEPRVASFVTPTKDFQSPTTALSNMTPNNAVEDSGKMRQSSLNEFHVFVCAAFLIKWSDQLMEMDFQETITFLQNPPTKDWTETDIEMLLSEAFIWQSLYKDATSHWL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | ERDHNSDSSSLVTSL HHCCCCCCHHHHHHH | 22.96 | 27017623 | |
| 20 | Phosphorylation | RDHNSDSSSLVTSLM HCCCCCCHHHHHHHH | 32.45 | 27017623 | |
| 21 | Phosphorylation | DHNSDSSSLVTSLMK CCCCCCHHHHHHHHH | 30.70 | 27017623 | |
| 33 | Phosphorylation | LMKSWRISSASSSKK HHHHHCCCCCCCCCC | 15.98 | 21440633 | |
| 48 | Phosphorylation | PSLYKMNTTESTSLP CCEEECCCCCCCCCC | 28.57 | 27017623 | |
| 49 | Phosphorylation | SLYKMNTTESTSLPS CEEECCCCCCCCCCC | 23.96 | 24961812 | |
| 51 | Phosphorylation | YKMNTTESTSLPSGY EECCCCCCCCCCCCC | 22.62 | 24961812 | |
| 52 | Phosphorylation | KMNTTESTSLPSGYA ECCCCCCCCCCCCCC | 28.22 | 24961812 | |
| 53 | Phosphorylation | MNTTESTSLPSGYAS CCCCCCCCCCCCCCC | 47.78 | 21440633 | |
| 56 | Phosphorylation | TESTSLPSGYASSAD CCCCCCCCCCCCCCC | 50.13 | 21440633 | |
| 58 | Phosphorylation | STSLPSGYASSADRD CCCCCCCCCCCCCCC | 13.98 | 24961812 | |
| 60 | Phosphorylation | SLPSGYASSADRDRR CCCCCCCCCCCCCCC | 19.99 | 28889911 | |
| 61 | Phosphorylation | LPSGYASSADRDRRT CCCCCCCCCCCCCCC | 26.47 | 24961812 | |
| 68 | Phosphorylation | SADRDRRTSDGNFEA CCCCCCCCCCCCHHH | 31.87 | 22369663 | |
| 69 | Phosphorylation | ADRDRRTSDGNFEAM CCCCCCCCCCCHHHH | 41.53 | 22369663 | |
| 86 | Phosphorylation | QQASTRRTSNSYSPL HHHHCCCCCCCCCCC | 29.03 | 22369663 | |
| 87 | Phosphorylation | QASTRRTSNSYSPLR HHHCCCCCCCCCCCC | 23.20 | 22369663 | |
| 89 | Phosphorylation | STRRTSNSYSPLRYV HCCCCCCCCCCCCCC | 27.10 | 22369663 | |
| 90 | Phosphorylation | TRRTSNSYSPLRYVN CCCCCCCCCCCCCCC | 20.68 | 22369663 | |
| 91 | Phosphorylation | RRTSNSYSPLRYVNP CCCCCCCCCCCCCCC | 19.78 | 22369663 | |
| 99 | Phosphorylation | PLRYVNPTLSTASNE CCCCCCCCCCCCCCC | 28.30 | 28132839 | |
| 101 | Phosphorylation | RYVNPTLSTASNESP CCCCCCCCCCCCCCC | 25.14 | 22369663 | |
| 102 | Phosphorylation | YVNPTLSTASNESPR CCCCCCCCCCCCCCC | 36.90 | 28132839 | |
| 104 | Phosphorylation | NPTLSTASNESPRPA CCCCCCCCCCCCCCH | 41.02 | 22369663 | |
| 107 | Phosphorylation | LSTASNESPRPALLL CCCCCCCCCCCHHHH | 30.38 | 22369663 | |
| 131 | Phosphorylation | HQQPRHSSSGSVGNN CCCCCCCCCCCCCCC | 32.37 | 28889911 | |
| 132 | Phosphorylation | QQPRHSSSGSVGNNC CCCCCCCCCCCCCCC | 37.79 | 23749301 | |
| 134 | Phosphorylation | PRHSSSGSVGNNCSN CCCCCCCCCCCCCCC | 28.88 | 23749301 | |
| 142 | Phosphorylation | VGNNCSNSTEPNKKG CCCCCCCCCCCCCCC | 20.18 | 30377154 | |
| 181 | Phosphorylation | LTNGGFGTPVAPTRT EECCCCCCCCCCCCC | 16.60 | 21440633 | |
| 193 | Phosphorylation | TRTLSRKSTSSSINS CCCCCCCCCCCCHHH | 32.20 | 28889911 | |
| 194 | Phosphorylation | RTLSRKSTSSSINSI CCCCCCCCCCCHHHH | 35.35 | 28889911 | |
| 195 | Phosphorylation | TLSRKSTSSSINSIS CCCCCCCCCCHHHHH | 29.22 | 30377154 | |
| 196 | Phosphorylation | LSRKSTSSSINSISN CCCCCCCCCHHHHHH | 35.01 | 30377154 | |
| 197 | Phosphorylation | SRKSTSSSINSISNM CCCCCCCCHHHHHHC | 26.09 | 25752575 | |
| 200 | Phosphorylation | STSSSINSISNMGTS CCCCCHHHHHHCCCH | 26.23 | 30377154 | |
| 206 | Phosphorylation | NSISNMGTSAVRNSS HHHHHCCCHHHHCCC | 11.62 | 21440633 | |
| 212 | Phosphorylation | GTSAVRNSSSSFTYP CCHHHHCCCCCCCCC | 22.49 | 22369663 | |
| 213 | Phosphorylation | TSAVRNSSSSFTYPQ CHHHHCCCCCCCCCC | 33.28 | 22890988 | |
| 214 | Phosphorylation | SAVRNSSSSFTYPQL HHHHCCCCCCCCCCC | 29.32 | 22890988 | |
| 215 | Phosphorylation | AVRNSSSSFTYPQLP HHHCCCCCCCCCCCH | 24.45 | 22369663 | |
| 217 | Phosphorylation | RNSSSSFTYPQLPQL HCCCCCCCCCCCHHH | 35.92 | 22890988 | |
| 218 | Phosphorylation | NSSSSFTYPQLPQLQ CCCCCCCCCCCHHHH | 6.23 | 22890988 | |
| 250 | Phosphorylation | RDVQELNSIIQRISK HHHHHHHHHHHHHHH | 33.42 | 28889911 | |
| 291 | Ubiquitination | IHRPVVWKLLIGYLP CCHHHHHHHHHHCCC | 23.08 | 17644757 | |
| 302 | Ubiquitination | GYLPVNTKRQEGFLQ HCCCCCCHHCCCHHH | 47.05 | 17644757 | |
| 311 | Ubiquitination | QEGFLQRKRKEYRDS CCCHHHHHHHHHHHH | 55.66 | 17644757 | |
| 431 | Ubiquitination | DTFWCLTKLLEQITD HHHHHHHHHHHHHHH | 37.82 | 17644757 | |
| 455 | Phosphorylation | LRQVKNLSQLVKRID HHHHHCHHHHHHHHC | 30.75 | 29734811 | |
| 506 | Phosphorylation | RMWDTYLSETSQEVT HCHHHHHHHCCCHHH | 28.54 | 27017623 | |
| 508 | Phosphorylation | WDTYLSETSQEVTSS HHHHHHHCCCHHHHH | 32.13 | 27017623 | |
| 509 | Phosphorylation | DTYLSETSQEVTSSY HHHHHHCCCHHHHHC | 21.94 | 27017623 | |
| 519 | Phosphorylation | VTSSYSMSSNDIKPP HHHHCCCCCCCCCCC | 21.76 | 27017623 | |
| 536 | Phosphorylation | PTEPRVASFVTPTKD CCCCCEECCCCCCCC | 19.86 | 23749301 | |
| 539 | Phosphorylation | PRVASFVTPTKDFQS CCEECCCCCCCCCCC | 24.19 | 21082442 | |
| 541 | Phosphorylation | VASFVTPTKDFQSPT EECCCCCCCCCCCCC | 33.60 | 25752575 | |
| 546 | Phosphorylation | TPTKDFQSPTTALSN CCCCCCCCCCHHHHC | 24.98 | 25521595 | |
| 548 | Phosphorylation | TKDFQSPTTALSNMT CCCCCCCCHHHHCCC | 29.92 | 25521595 | |
| 549 | Phosphorylation | KDFQSPTTALSNMTP CCCCCCCHHHHCCCC | 29.05 | 25521595 | |
| 552 | Phosphorylation | QSPTTALSNMTPNNA CCCCHHHHCCCCCCH | 23.30 | 22369663 | |
| 555 | Phosphorylation | TTALSNMTPNNAVED CHHHHCCCCCCHHCC | 27.41 | 22369663 | |
| 563 | Phosphorylation | PNNAVEDSGKMRQSS CCCHHCCCCCCCCHH | 27.14 | 22369663 | |
| 627 | Phosphorylation | SEAFIWQSLYKDATS HHHHHHHHHHHHHHH | 20.76 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GYP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GYP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GYP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-90; SER-193; THR-194;SER-197; SER-212; SER-215; SER-250; THR-539 AND SER-546, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-91, AND MASSSPECTROMETRY. | |
