IRS4_YEAST - dbPTM
IRS4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IRS4_YEAST
UniProt AC P36115
Protein Name Increased rDNA silencing protein 4
Gene Name IRS4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 615
Subcellular Localization
Protein Description With TAX4, acts as a positive regulator of INP51 activity and phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates signaling through the cell integrity pathway, including the MAP kinase SLT2. Seems also to be involved in rDNA silencing..
Protein Sequence MRLSFGKQRYHGGTTVTLTEQGASDSLRAAQAIFQNHSNEVSSPCPPVTVSRNPQTRLSEPSLQKSGRKQEQKKARIRTKQVPKIKTTAPNDVELSKKHRSSPAGKDNVSSTAQMAAALAHSQSKLSSDNNSSHSSALDTLKVLETPNLNGLLGIHSRSSSRNGSNESLTPGQRTPDNRSQENLLTSFSSGRRLSSSSMEPATNKDSNKALPKRRPSPPLQSSLVGSGQLHENENLSSISIDSRHSLNPDTSDVISNRSQTSLSQTINQLSLCESEPSIASSNTTTTTSNQGSGLPNLVPNYSSDMRKKKLVNKFKRKVFGSKPKHLSSQYEMDASSEELGQHEQQPSMRFKTTLRKTSVSTNAENDHASSLHEGNLRYKYNPSNDTYDVYDDTDSDSESDQNQDALTKPRKRDRIKRKIRNSANKTAHHRPIHRTRDRKFNEDKPWKSHTDITFVTDNERKRYESMWVSNRHRHLNLLSWWPSITGDSGAINTLPEDGLILGIIVRDIWKRSNLPNSLLAEIYTKVDTRKDGTLDRKSFIVGMWLVDQCLYGRKLPNVVEQCVWDSVDRYASTTVVPVSTLKAMAKQKRKQMKEEIKNIKKENRVVLVDHNSSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
102PhosphorylationLSKKHRSSPAGKDNV
HHHHHCCCCCCCCCH		20.8021551504
110PhosphorylationPAGKDNVSSTAQMAA
CCCCCCHHHHHHHHH		28.3821551504
128PhosphorylationHSQSKLSSDNNSSHS
HHHHHHCCCCCCCCC		55.5921551504
132PhosphorylationKLSSDNNSSHSSALD
HHCCCCCCCCCHHHH		35.3621440633
133PhosphorylationLSSDNNSSHSSALDT
HCCCCCCCCCHHHHH		29.5221440633
135PhosphorylationSDNNSSHSSALDTLK
CCCCCCCCHHHHHHH		21.1821440633
136PhosphorylationDNNSSHSSALDTLKV
CCCCCCCHHHHHHHH		27.6821440633
157PhosphorylationNGLLGIHSRSSSRNG
CCCCEEECCCCCCCC		31.7522369663
165PhosphorylationRSSSRNGSNESLTPG
CCCCCCCCCCCCCCC		40.7628889911
168PhosphorylationSRNGSNESLTPGQRT
CCCCCCCCCCCCCCC		41.6228889911
175PhosphorylationSLTPGQRTPDNRSQE
CCCCCCCCCCCCCHH		27.4028889911
180PhosphorylationQRTPDNRSQENLLTS
CCCCCCCCHHHHHHH		48.3729650682
195PhosphorylationFSSGRRLSSSSMEPA
HCCCCCCCCCCCCCC		26.7722369663
196PhosphorylationSSGRRLSSSSMEPAT
CCCCCCCCCCCCCCC		30.9022369663
197PhosphorylationSGRRLSSSSMEPATN
CCCCCCCCCCCCCCC		30.2622369663
198PhosphorylationGRRLSSSSMEPATNK
CCCCCCCCCCCCCCC		29.1622369663
203PhosphorylationSSSMEPATNKDSNKA
CCCCCCCCCCCCCCC		54.2222369663
246PhosphorylationISIDSRHSLNPDTSD
CEECCCCCCCCCHHH		28.8228889911
256PhosphorylationPDTSDVISNRSQTSL
CCHHHHHCCCCHHHH		26.4928889911
331PhosphorylationPKHLSSQYEMDASSE
CCCCCHHHCCCCCHH		18.3727017623
336PhosphorylationSQYEMDASSEELGQH
HHHCCCCCHHHHHHH		33.7424961812
337PhosphorylationQYEMDASSEELGQHE
HHCCCCCHHHHHHHC		36.4924961812
348PhosphorylationGQHEQQPSMRFKTTL
HHHCCCCCHHCCCEE		20.4624961812
353PhosphorylationQPSMRFKTTLRKTSV
CCCHHCCCEEECCCC		28.4924961812
354PhosphorylationPSMRFKTTLRKTSVS
CCHHCCCEEECCCCC		25.7524961812
358PhosphorylationFKTTLRKTSVSTNAE
CCCEEECCCCCCCCC		28.1128889911
359PhosphorylationKTTLRKTSVSTNAEN
CCEEECCCCCCCCCC		19.6725005228
361PhosphorylationTLRKTSVSTNAENDH
EEECCCCCCCCCCCC		18.7321440633
362PhosphorylationLRKTSVSTNAENDHA
EECCCCCCCCCCCCC		35.9728889911
370PhosphorylationNAENDHASSLHEGNL
CCCCCCCCCCCCCCE		29.9721440633
371PhosphorylationAENDHASSLHEGNLR
CCCCCCCCCCCCCEE		34.2321440633
394PhosphorylationTYDVYDDTDSDSESD
CEEECCCCCCCCCCH		34.2121551504
396PhosphorylationDVYDDTDSDSESDQN
EECCCCCCCCCCHHC		45.1621551504
400PhosphorylationDTDSDSESDQNQDAL
CCCCCCCCHHCHHHH		48.7421551504
613PhosphorylationVVLVDHNSSS-----
EEEEECCCCC-----		28.6520377248
614PhosphorylationVLVDHNSSS------
EEEECCCCC------		45.4422369663
615PhosphorylationLVDHNSSS-------
EEECCCCC-------		44.0220377248
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IRS4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IRS4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IRS4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FNTB_YEASTRAM1genetic
19269370
IPK1_YEASTIPK1genetic
19269370
SWI4_YEASTSWI4genetic
19269370
SKN7_YEASTSKN7genetic
19269370
LSM7_YEASTLSM7genetic
19269370
CLA4_YEASTCLA4genetic
19269370
MCK1_YEASTMCK1genetic
19269370
CSK2C_YEASTCKB2genetic
19269370
BECN1_YEASTVPS30genetic
19269370
CSM1_YEASTCSM1genetic
18997772
SIR2_YEASTSIR2genetic
18997772
TAX4_YEASTTAX4genetic
18298591
ETR1_YEASTETR1genetic
20093466
DER1_YEASTDER1genetic
20093466
STE50_YEASTSTE50genetic
20093466
SNT1_YEASTSNT1genetic
20093466
PP2C1_YEASTPTC1genetic
20093466
PAA1_YEASTPAA1genetic
20093466
TRS85_YEASTTRS85genetic
20093466
RAV2_YEASTRAV2genetic
20093466
PHM6_YEASTPHM6genetic
20093466
MRX8_YEASTYDR336Wgenetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
ERD1_YEASTERD1genetic
20093466
GET2_YEASTGET2genetic
20093466
DCV1_YEASTDCV1genetic
20093466
RL24A_YEASTRPL24Agenetic
20093466
GET1_YEASTGET1genetic
20093466
RSSA1_YEASTRPS0Agenetic
20093466
SLH1_YEASTSLH1genetic
20093466
AIR1_YEASTAIR1genetic
20093466
YIT6_YEASTYIR016Wgenetic
20093466
MNN11_YEASTMNN11genetic
20093466
GSH1_YEASTGSH1genetic
20093466
SIP4_YEASTSIP4genetic
20093466
CYP7_YEASTCPR7genetic
20093466
YPT6_YEASTYPT6genetic
20093466
SCS7_YEASTSCS7genetic
20093466
GAS1_YEASTGAS1genetic
20093466
YNE0_YEASTYNL040Wgenetic
20093466
TLG2_YEASTTLG2genetic
20093466
GYP1_YEASTGYP1genetic
20093466
OST3_YEASTOST3genetic
20093466
RCN2_YEASTRCN2genetic
20093466
YP068_YEASTYPL068Cgenetic
20093466
CWC27_YEASTCWC27genetic
20093466
ARL3_YEASTARL3genetic
20093466
INP51_YEASTINP51physical
22940862
PHO80_YEASTPHO80genetic
24586198
TAX4_YEASTTAX4genetic
24586198
STU1_YEASTSTU1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
KRR1_YEASTKRR1genetic
27708008
PRP9_YEASTPRP9genetic
27708008
CDC37_YEASTCDC37genetic
27708008
GPI8_YEASTGPI8genetic
27708008
GPI10_YEASTGPI10genetic
27708008
CDC11_YEASTCDC11genetic
27708008
MED14_YEASTRGR1genetic
27708008
UTP13_YEASTUTP13genetic
27708008
SEC22_YEASTSEC22genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
GPI12_YEASTGPI12genetic
27708008
ATG14_YEASTATG14genetic
27708008
MBA1_YEASTMBA1genetic
27708008
GPR1_YEASTGPR1genetic
27708008
SAC7_YEASTSAC7genetic
27708008
FCY21_YEASTFCY21genetic
27708008
DCV1_YEASTDCV1genetic
27708008
RSSA1_YEASTRPS0Agenetic
27708008
GOSR1_YEASTGOS1genetic
27708008
MNT3_YEASTMNT3genetic
27708008
YJN2_YEASTYJL132Wgenetic
27708008
PAU4_YEASTPAU4genetic
27708008
TMA23_YEASTTMA23genetic
27708008
YNE0_YEASTYNL040Wgenetic
27708008
RCN2_YEASTRCN2genetic
27708008
CWC27_YEASTCWC27genetic
27708008
YP068_YEASTYPL068Cgenetic
27708008
KA120_YEASTKAP120genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IRS4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614, AND MASSSPECTROMETRY.

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