| UniProt ID | CLA4_YEAST | |
|---|---|---|
| UniProt AC | P48562 | |
| Protein Name | Serine/threonine-protein kinase CLA4 | |
| Gene Name | CLA4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 842 | |
| Subcellular Localization | ||
| Protein Description | Involved in budding and cytokinesis.. | |
| Protein Sequence | MSLSAAANKISDNDFQNIGPAPRPPSSNSQGRTCYNQTQPITKLMSQLDLTSASHLGTSTSKKKSGWVSYKDDGILSFIWQKRYLMLHDSYVALYKNDKQNDDAILKIPLTSIISVSRTQLKQYCFELVRCSDRNSVSSGSSSSLNVSSDSNSKKSIYIATKTESDLHSWLDAIFAKCPLLSGVSSPTNFTHKVHVGFDPETGSFVGMPTNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEYNGAGNPTNTLDKPQSGETSSSQKSLPNSYNDNKLRNNSVNSKSSSGVSSSMVSQRKTSQPPNTKSPVSLGSGSLPPINTKLPTSQSNIPRHLQNVPNQQYPKMRNGHSPTNGQFPRGPMHPNNSQRSLQQQQQQQQQQKQQHQQYPYHHQGPSPSPSPSPSPLNPYRPHHNMINPYSKQPQSPLSSQSTQNQAIPRYAQNSSPTAAHFQPQRTAPKPPISAPRAPYPSNQNATSNTHVQPVAPKNDQSTPQTMRQAPKRPDADVAQPGGVAKPKKPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFNMACDPKDLTSLLEWKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MSLSAAANKIS ----CCHHHHHHCCC | 14.46 | 30377154 | |
| 26 | Phosphorylation | GPAPRPPSSNSQGRT CCCCCCCCCCCCCCC | 44.85 | 22369663 | |
| 27 | Phosphorylation | PAPRPPSSNSQGRTC CCCCCCCCCCCCCCC | 46.40 | 22369663 | |
| 29 | Phosphorylation | PRPPSSNSQGRTCYN CCCCCCCCCCCCCCC | 35.64 | 22369663 | |
| 33 | Phosphorylation | SSNSQGRTCYNQTQP CCCCCCCCCCCCCCH | 26.60 | 21440633 | |
| 38 | Phosphorylation | GRTCYNQTQPITKLM CCCCCCCCCHHHHHH | 32.45 | 27017623 | |
| 46 | Phosphorylation | QPITKLMSQLDLTSA CHHHHHHHHCCCCCH | 37.72 | 21551504 | |
| 52 | Phosphorylation | MSQLDLTSASHLGTS HHHCCCCCHHHCCCC | 34.76 | 21440633 | |
| 54 | Phosphorylation | QLDLTSASHLGTSTS HCCCCCHHHCCCCCC | 21.00 | 21551504 | |
| 91 | Phosphorylation | YLMLHDSYVALYKND EHHHHHHEEEEECCC | 8.87 | 19779198 | |
| 95 | Phosphorylation | HDSYVALYKNDKQND HHHEEEEECCCCCCC | 9.67 | 19779198 | |
| 124 | Phosphorylation | SRTQLKQYCFELVRC CHHHHHHHHHHHHCC | 9.49 | 19779198 | |
| 132 | Phosphorylation | CFELVRCSDRNSVSS HHHHHCCCCCCCCCC | 29.10 | 19779198 | |
| 136 | Phosphorylation | VRCSDRNSVSSGSSS HCCCCCCCCCCCCCC | 25.03 | 23749301 | |
| 138 | Phosphorylation | CSDRNSVSSGSSSSL CCCCCCCCCCCCCCC | 28.89 | 22369663 | |
| 139 | Phosphorylation | SDRNSVSSGSSSSLN CCCCCCCCCCCCCCE | 40.30 | 22369663 | |
| 141 | Phosphorylation | RNSVSSGSSSSLNVS CCCCCCCCCCCCEEC | 29.06 | 22369663 | |
| 142 | Phosphorylation | NSVSSGSSSSLNVSS CCCCCCCCCCCEECC | 27.72 | 22369663 | |
| 143 | Phosphorylation | SVSSGSSSSLNVSSD CCCCCCCCCCEECCC | 40.31 | 22369663 | |
| 144 | Phosphorylation | VSSGSSSSLNVSSDS CCCCCCCCCEECCCC | 26.38 | 22369663 | |
| 182 | Phosphorylation | FAKCPLLSGVSSPTN HHHCCCCCCCCCCCC | 44.85 | 30377154 | |
| 185 | Phosphorylation | CPLLSGVSSPTNFTH CCCCCCCCCCCCCCC | 33.84 | 28889911 | |
| 186 | Phosphorylation | PLLSGVSSPTNFTHK CCCCCCCCCCCCCCE | 33.08 | 28152593 | |
| 188 | Phosphorylation | LSGVSSPTNFTHKVH CCCCCCCCCCCCEEE | 44.93 | 27017623 | |
| 191 | Phosphorylation | VSSPTNFTHKVHVGF CCCCCCCCCEEEEEE | 23.90 | 21440633 | |
| 202 | Phosphorylation | HVGFDPETGSFVGMP EEEECCCCCCCCCCC | 43.44 | 24961812 | |
| 204 | Phosphorylation | GFDPETGSFVGMPTN EECCCCCCCCCCCCC | 24.95 | 24961812 | |
| 267 | Phosphorylation | ETSSSQKSLPNSYND CCCCCCCCCCCCCCC | 41.23 | 22369663 | |
| 281 | Phosphorylation | DNKLRNNSVNSKSSS CCCCCCCCCCCCCCC | 26.65 | 21440633 | |
| 284 | Phosphorylation | LRNNSVNSKSSSGVS CCCCCCCCCCCCCCC | 31.58 | 21440633 | |
| 286 | Phosphorylation | NNSVNSKSSSGVSSS CCCCCCCCCCCCCHH | 29.56 | 22369663 | |
| 287 | Phosphorylation | NSVNSKSSSGVSSSM CCCCCCCCCCCCHHH | 34.54 | 22369663 | |
| 288 | Phosphorylation | SVNSKSSSGVSSSMV CCCCCCCCCCCHHHH | 50.75 | 22369663 | |
| 291 | Phosphorylation | SKSSSGVSSSMVSQR CCCCCCCCHHHHHCC | 21.88 | 21551504 | |
| 292 | Phosphorylation | KSSSGVSSSMVSQRK CCCCCCCHHHHHCCC | 21.75 | 22369663 | |
| 293 | Phosphorylation | SSSGVSSSMVSQRKT CCCCCCHHHHHCCCC | 18.72 | 22369663 | |
| 296 | Phosphorylation | GVSSSMVSQRKTSQP CCCHHHHHCCCCCCC | 18.67 | 21440633 | |
| 300 | Phosphorylation | SMVSQRKTSQPPNTK HHHHCCCCCCCCCCC | 34.48 | 21551504 | |
| 301 | Phosphorylation | MVSQRKTSQPPNTKS HHHCCCCCCCCCCCC | 43.66 | 21440633 | |
| 306 | Phosphorylation | KTSQPPNTKSPVSLG CCCCCCCCCCCCCCC | 38.38 | 27017623 | |
| 308 | Phosphorylation | SQPPNTKSPVSLGSG CCCCCCCCCCCCCCC | 28.61 | 28889911 | |
| 311 | Phosphorylation | PNTKSPVSLGSGSLP CCCCCCCCCCCCCCC | 30.32 | 28889911 | |
| 314 | Phosphorylation | KSPVSLGSGSLPPIN CCCCCCCCCCCCCCC | 30.42 | 21551504 | |
| 327 | Phosphorylation | INTKLPTSQSNIPRH CCCCCCCCCCCCCHH | 29.67 | 21551504 | |
| 329 | Phosphorylation | TKLPTSQSNIPRHLQ CCCCCCCCCCCHHHH | 36.17 | 30377154 | |
| 351 | Phosphorylation | PKMRNGHSPTNGQFP CCCCCCCCCCCCCCC | 34.51 | 17330950 | |
| 353 | Phosphorylation | MRNGHSPTNGQFPRG CCCCCCCCCCCCCCC | 55.80 | 24909858 | |
| 367 | Phosphorylation | GPMHPNNSQRSLQQQ CCCCCCHHHHHHHHH | 33.34 | 11875433 | |
| 370 | Phosphorylation | HPNNSQRSLQQQQQQ CCCHHHHHHHHHHHH | 23.93 | 22369663 | |
| 388 | Phosphorylation | QKQQHQQYPYHHQGP HHHHHHHCCCCCCCC | 10.13 | 24961812 | |
| 390 | Phosphorylation | QQHQQYPYHHQGPSP HHHHHCCCCCCCCCC | 13.65 | 24961812 | |
| 396 | Phosphorylation | PYHHQGPSPSPSPSP CCCCCCCCCCCCCCC | 44.85 | 24961812 | |
| 398 | Phosphorylation | HHQGPSPSPSPSPSP CCCCCCCCCCCCCCC | 42.20 | 24961812 | |
| 400 | Phosphorylation | QGPSPSPSPSPSPLN CCCCCCCCCCCCCCC | 42.20 | 24961812 | |
| 402 | Phosphorylation | PSPSPSPSPSPLNPY CCCCCCCCCCCCCCC | 42.20 | 24961812 | |
| 404 | Phosphorylation | PSPSPSPSPLNPYRP CCCCCCCCCCCCCCC | 46.48 | 24961812 | |
| 409 | Phosphorylation | SPSPLNPYRPHHNMI CCCCCCCCCCCCCCC | 35.39 | 24961812 | |
| 419 | Phosphorylation | HHNMINPYSKQPQSP CCCCCCCCCCCCCCC | 24.82 | 24961812 | |
| 420 | Phosphorylation | HNMINPYSKQPQSPL CCCCCCCCCCCCCCC | 26.52 | 24961812 | |
| 425 | Phosphorylation | PYSKQPQSPLSSQST CCCCCCCCCCCCCCH | 34.20 | 21082442 | |
| 428 | Phosphorylation | KQPQSPLSSQSTQNQ CCCCCCCCCCCHHHC | 29.70 | 25371407 | |
| 429 | Phosphorylation | QPQSPLSSQSTQNQA CCCCCCCCCCHHHCH | 35.51 | 23607784 | |
| 431 | Phosphorylation | QSPLSSQSTQNQAIP CCCCCCCCHHHCHHC | 33.63 | 23749301 | |
| 440 | Phosphorylation | QNQAIPRYAQNSSPT HHCHHCHHHHCCCCC | 13.74 | 19779198 | |
| 444 | Phosphorylation | IPRYAQNSSPTAAHF HCHHHHCCCCCCCCC | 26.14 | 22369663 | |
| 445 | Phosphorylation | PRYAQNSSPTAAHFQ CHHHHCCCCCCCCCC | 33.54 | 22369663 | |
| 447 | Phosphorylation | YAQNSSPTAAHFQPQ HHHCCCCCCCCCCCC | 38.12 | 22369663 | |
| 469 | Phosphorylation | ISAPRAPYPSNQNAT CCCCCCCCCCCCCCC | 20.50 | 22369663 | |
| 471 | Phosphorylation | APRAPYPSNQNATSN CCCCCCCCCCCCCCC | 45.25 | 22369663 | |
| 476 | Phosphorylation | YPSNQNATSNTHVQP CCCCCCCCCCCCCCC | 30.02 | 23749301 | |
| 477 | Phosphorylation | PSNQNATSNTHVQPV CCCCCCCCCCCCCCC | 37.00 | 22369663 | |
| 479 | Phosphorylation | NQNATSNTHVQPVAP CCCCCCCCCCCCCCC | 24.16 | 22369663 | |
| 491 | Phosphorylation | VAPKNDQSTPQTMRQ CCCCCCCCCHHHHHH | 44.94 | 21440633 | |
| 492 | Phosphorylation | APKNDQSTPQTMRQA CCCCCCCCHHHHHHC | 17.49 | 21440633 | |
| 495 | Phosphorylation | NDQSTPQTMRQAPKR CCCCCHHHHHHCCCC | 18.61 | 23749301 | |
| 523 | Phosphorylation | PKKPARPTMSTAEIM CCCCCCCCCCHHHHH | 20.42 | 30377154 | |
| 525 | Phosphorylation | KPARPTMSTAEIMSK CCCCCCCCHHHHHHH | 27.26 | 30377154 | |
| 526 | Phosphorylation | PARPTMSTAEIMSKL CCCCCCCHHHHHHHC | 19.93 | 30377154 | |
| 559 | Phosphorylation | AGQGASGSVYLAERT HCCCCCCCEEEEECC | 12.70 | 27017623 | |
| 561 | Phosphorylation | QGASGSVYLAERTHI CCCCCCEEEEECCCC | 11.24 | 27017623 | |
| 696 | Phosphorylation | IIHRDIKSDNVLLDT EEECCCCCCCEEECC | 34.45 | 19779198 | |
| 727 | Phosphorylation | DKRSKRATMVGTPYW CCCCCCCEECCCCCC | 19.20 | 19779198 | |
| 731 | Phosphorylation | KRATMVGTPYWMAPE CCCEECCCCCCCCHH | 11.20 | 21440633 | |
| 733 | Phosphorylation | ATMVGTPYWMAPEVV CEECCCCCCCCHHHH | 13.98 | 21440633 | |
| 816 | Phosphorylation | DVRYRASTEELLHHG EEECCCCHHHHHHHC | 32.28 | 28889911 | |
| 836 | Phosphorylation | CDPKDLTSLLEWKE- CCHHHHHHHHHHCC- | 37.95 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLA4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLA4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLA4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-27; SER-29;SER-46; SER-186; SER-351; SER-425 AND SER-445, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26; SER-351 AND SER-445,AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367 AND SER-370, ANDMASS SPECTROMETRY. | |
