DMA2_YEAST - dbPTM
DMA2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DMA2_YEAST
UniProt AC P53924
Protein Name E3 ubiquitin-protein ligase DMA2
Gene Name DMA2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 522
Subcellular Localization Cytoplasm .
Protein Description E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjonction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugationg enzymes. Involved in nutritional control of the cell cycle. Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck..
Protein Sequence MYTPIPANTPAPTAPTSSMTSNSSSASNANTTSSSGINPRNRASGTPSNERARPASGISSFLNTFGIRQNSQTASSSAAPDQRLFGTTPSNSHMSVAMESIDTAPQQQEPRLHHPIQMPLSAQFHVHRNYQLPISISLTAPTTTDHQQSSAHNFEGNNVGNVQESLNQRQPNGTNNTTTSIISMAPAATTRNIVGGADGSTIVNNSQEMYKNLRHLIYAANQPNGTEILHLDLPATSAEESNNMFNVDEVTLKQRKDKHGLFSIRLTPFIDSSSTTNQGLFFEPIIRKAGPGSQLVIGRYTERVRDAISKIPEQYHPVVFKSKVVSRTHGCFKVDSQGNWYIKDVKSSSGTFLNHQRLSPASSLSKDTPLRDGDILQLGMDFRGGTEEIYRCVRMRIELNRSWKLKANSFNKEALQRLQNLQKLTTGIEEEDCSICLCKIKPCQAIFISPCAHSWHFRCVRRLVMLSYPQFVCPNCRSSCDLEASFESSDEEDESDVESEGDQLVDQLSVLMETSKDVDSHP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationPRNRASGTPSNERAR
CCCCCCCCCCCCCCC		22.5028889911
56PhosphorylationNERARPASGISSFLN
CCCCCCCCCHHHHHH		39.0630377154
59PhosphorylationARPASGISSFLNTFG
CCCCCCHHHHHHHHC		20.6830377154
60PhosphorylationRPASGISSFLNTFGI
CCCCCHHHHHHHHCC		31.6530377154
71PhosphorylationTFGIRQNSQTASSSA
HHCCCCCCCCCCCCC		22.1422369663
73PhosphorylationGIRQNSQTASSSAAP
CCCCCCCCCCCCCCC		28.4722369663
75PhosphorylationRQNSQTASSSAAPDQ
CCCCCCCCCCCCCCC		28.3622369663
76PhosphorylationQNSQTASSSAAPDQR
CCCCCCCCCCCCCCC		22.8722369663
77PhosphorylationNSQTASSSAAPDQRL
CCCCCCCCCCCCCCC		26.4222369663
87PhosphorylationPDQRLFGTTPSNSHM
CCCCCCCCCCCCCCH		28.3523749301
88PhosphorylationDQRLFGTTPSNSHMS
CCCCCCCCCCCCCHH		25.7125752575
90PhosphorylationRLFGTTPSNSHMSVA
CCCCCCCCCCCHHEE		49.2027017623
92PhosphorylationFGTTPSNSHMSVAME
CCCCCCCCCHHEEEE		25.5528889911
95PhosphorylationTPSNSHMSVAMESID
CCCCCCHHEEEECCC		10.9928889911
130PhosphorylationQFHVHRNYQLPISIS
EEEEECCCCCCEEEE		16.0429688323
135PhosphorylationRNYQLPISISLTAPT
CCCCCCEEEEEECCC		12.2729688323
137PhosphorylationYQLPISISLTAPTTT
CCCCEEEEEECCCCC		16.9329688323
139PhosphorylationLPISISLTAPTTTDH
CCEEEEEECCCCCCC		24.6529688323
142PhosphorylationSISLTAPTTTDHQQS
EEEEECCCCCCCCCH		39.6029688323
143PhosphorylationISLTAPTTTDHQQSS
EEEECCCCCCCCCHH		29.2129688323
144PhosphorylationSLTAPTTTDHQQSSA
EEECCCCCCCCCHHC		33.6829688323
149PhosphorylationTTTDHQQSSAHNFEG
CCCCCCCHHCCCCCC		23.9529688323
150PhosphorylationTTDHQQSSAHNFEGN
CCCCCCHHCCCCCCC		29.2529688323
165PhosphorylationNVGNVQESLNQRQPN
CCCCHHHHHHCCCCC		18.6129688323
206PhosphorylationGSTIVNNSQEMYKNL
CCCCCCCCHHHHHHH		23.4725752575
210PhosphorylationVNNSQEMYKNLRHLI
CCCCHHHHHHHHHHH		8.9327017623
211UbiquitinationNNSQEMYKNLRHLIY
CCCHHHHHHHHHHHH		48.4718202552
256UbiquitinationEVTLKQRKDKHGLFS
EEEEEECCCCCCCEE		69.5018202552
258UbiquitinationTLKQRKDKHGLFSIR
EEEECCCCCCCEEEE		42.4818202552
288UbiquitinationFFEPIIRKAGPGSQL
EEHHHHHHCCCCCEE		47.4923749301
310UbiquitinationRVRDAISKIPEQYHP
HHHHHHHCCCHHHCC		57.0518202552
333UbiquitinationSRTHGCFKVDSQGNW
EECCCEEEECCCCCE		49.5718202552
343UbiquitinationSQGNWYIKDVKSSSG
CCCCEEEEEEECCCC		40.5518202552
346UbiquitinationNWYIKDVKSSSGTFL
CEEEEEEECCCCCCC		55.5418202552
362PhosphorylationHQRLSPASSLSKDTP
CCCCCCCHHCCCCCC		34.8827017623
366UbiquitinationSPASSLSKDTPLRDG
CCCHHCCCCCCCCCC		71.5518202552
406UbiquitinationLNRSWKLKANSFNKE
HCCCCEECCCCCCHH		41.6218202552
409PhosphorylationSWKLKANSFNKEALQ
CCEECCCCCCHHHHH		34.7529136822
412UbiquitinationLKANSFNKEALQRLQ
ECCCCCCHHHHHHHH		42.2123749301
423UbiquitinationQRLQNLQKLTTGIEE
HHHHHHHHHHHCCCH		51.4718202552
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DMA2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
211Kubiquitylation

18202552
211Kubiquitylation

18202552
256Kubiquitylation

18202552
258Kubiquitylation

18202552
258Kubiquitylation

18202552
258Kubiquitylation

18202552
288Kubiquitylation

18202552
288Kubiquitylation

18202552
310Kubiquitylation

18202552
310Kubiquitylation

18202552
310Kubiquitylation

18202552
333Kubiquitylation

18202552
343Kubiquitylation

18202552
343Kubiquitylation

18202552
346Kubiquitylation

18202552
346Kubiquitylation

18202552
366Kubiquitylation

18202552
366Kubiquitylation

18202552
366Kubiquitylation

18202552
406Kubiquitylation

18202552
412Kubiquitylation

18202552
412Kubiquitylation

18202552
423Kubiquitylation

18202552
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DMA2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STH1_YEASTSTH1physical
11805837
PHO84_YEASTPHO84physical
11805837
GDE1_YEASTGDE1physical
11805837
SKP2_YEASTSKP2physical
11805837
CD123_YEASTCDC123physical
15319434
UBC4_YEASTUBC4genetic
18202552
UBC13_YEASTUBC13genetic
18202552
MMS2_YEASTMMS2genetic
18202552
ERR1_YEASTERR1physical
18467557
ERR2_YEASTERR1physical
18467557
RS8A_YEASTRPS8Agenetic
19061648
RS8B_YEASTRPS8Agenetic
19061648
SYKM_YEASTMSK1genetic
19061648
NOT4_YEASTMOT2genetic
19061648
DMA1_YEASTDMA1genetic
19269370
DMA1_YEASTDMA1genetic
18931302
UBP3_YEASTUBP3genetic
18931302
BUB2_YEASTBUB2genetic
15146058
HSL1_YEASTHSL1genetic
21562220
2ABA_YEASTCDC55genetic
21562220
SWE1_YEASTSWE1genetic
21562220
MPIP_YEASTMIH1genetic
21562220
BNI5_YEASTBNI5genetic
21562220
PP2C1_YEASTPTC1genetic
21127252
MOT3_YEASTMOT3genetic
21127252
CHA4_YEASTCHA4genetic
21127252
PACC_YEASTRIM101genetic
21127252
REI1_YEASTREI1genetic
21127252
DMA1_YEASTDMA1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
IXR1_YEASTIXR1genetic
21127252
GLN3_YEASTGLN3genetic
21127252
MED5_YEASTNUT1genetic
21127252
SUM1_YEASTSUM1genetic
21127252
RTG3_YEASTRTG3genetic
21127252
PLM2_YEASTPLM2genetic
21127252
ARGR2_YEASTARG81genetic
21127252
VPS71_YEASTVPS71genetic
21127252
RCO1_YEASTRCO1genetic
21127252
MSN2_YEASTMSN2genetic
21127252
DCC1_YEASTDCC1genetic
21127252
CTF8_YEASTCTF8genetic
21127252
2A5D_YEASTRTS1genetic
22570619
SHS1_YEASTSHS1genetic
22570619
CDC12_YEASTCDC12genetic
22570619
SWE1_YEASTSWE1genetic
22570619
KIN4_YEASTKIN4genetic
22570619
ELM1_YEASTELM1genetic
22570619
BNI4_YEASTBNI4genetic
22570619
SHS1_YEASTSHS1physical
23442799
UBC5_YEASTUBC5physical
23442799
UBC13_YEASTUBC13physical
23442799
CYK3_YEASTCYK3genetic
23966170
CHS2_YEASTCHS2genetic
23966170
DMA2_YEASTDMA2physical
23442799
POG1_YEASTPOG1genetic
25073408
DMA2_YEASTDMA2physical
18202552
UBC4_YEASTUBC4physical
18202552
UBC13_YEASTUBC13physical
18202552
DMA1_YEASTDMA1physical
18202552
UB2D2_HUMANUBE2D2physical
23442799
COM1_YEASTSAE2physical
25762720
VHS2_YEASTVHS2genetic
24646733
MRM2_YEASTMRM2genetic
27708008
MEP1_YEASTMEP1genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
AGP2_YEASTAGP2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
PHO2_YEASTPHO2genetic
27708008
HBT1_YEASTHBT1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
RTF1_YEASTRTF1genetic
27708008
ASK10_YEASTASK10genetic
27708008
CSK21_YEASTCKA1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
NU188_YEASTNUP188genetic
27708008
RCO1_YEASTRCO1genetic
27708008
VHS3_YEASTVHS3genetic
27708008
DGK1_YEASTDGK1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
BNI1_YEASTBNI1genetic
27449057
BNI1_YEASTBNI1physical
27449057
BNR1_YEASTBNR1physical
27449057
GIC1_YEASTGIC1genetic
27449057
GIC2_YEASTGIC2genetic
27449057
RHO1_YEASTRHO1genetic
26179915
KPC1_YEASTPKC1genetic
26179915
SYP1_YEASTSYP1genetic
26179915
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DMA2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; SER-95 AND SER-206,AND MASS SPECTROMETRY.
Ubiquitylation
ReferencePubMed
"Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 andUbc13/Mms2-dependent ubiquitination.";
Loring G.L., Christensen K.C., Gerber S.A., Brenner C.;
Cell Cycle 7:96-105(2008).
Cited for: FUNCTION, MASS SPECTROMETRY, AND UBIQUITINATION AT LYS-211; LYS-256;LYS-258; LYS-288; LYS-310; LYS-333; LYS-343; LYS-346; LYS-366;LYS-406; LYS-412 AND LYS-423.

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