SKP2_YEAST - dbPTM
SKP2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SKP2_YEAST
UniProt AC P42843
Protein Name F-box protein SKP2
Gene Name SKP2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 763
Subcellular Localization Cytoplasm .
Protein Description Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Regulates protein levels of sulfur metabolism enzymes. The SCF(SKP2) complex may regulate some transcription factors or regulators of cysteine and methionine biosynthesis..
Protein Sequence MKRLQLFGRSKYFSLVSSAAKEEEEEEEGCADAKSLLHSTSHDIKSRSLRFNDKSSLMCLPTKVLLLILRTLDFNTLVTLCQVNSRFYNLITNEFLFQNVILDSKLSLLKFNALIHSEFHTSNIVTHSGDCSTQSRSQNARFLVRSIEFKNPQSQDSLLKYSKFYNKSGQDSIIAGSYKLDSYDKDVKKLNNIRLNDETPIITSERIKLLDKLESNYFHYTYIELMLDIIDYLPNLTRVILSDVEPNFKIPLWYSVFNDGSRDFFKKIIKGQQSITNEDLRTFQLSKKFVKEYESKYYSLPRLKILEIKANNKRQRTFNRQRHHQKLVLRPSLFCCFGIINELKLENVTIDTESLDTPMEFLPLFLKNEDNELYSLQSPITALTLDSCDVVPGNGILRLFHSYFKMVKHLSLLKINSKFDLLLCSCFPSLSNLTIDCNSKCFTNEQVVGESYYFQQRSLDTEDDFDDCNSMTETLFEAPSDSKIITPPPTSSVVLSLNLNYISRTTGNDVSNNPSPDNNKKPAMLTAAQLQNFQRQRIPEFHSFYHYYRLLWERLPSKNISINVINIPFTNVYPLSPLSFWEHLARTITSVDETDEDVGDENDQETLIGYENNSIRDNIPNANAVPNLSTVMSPESDIHHTYYWNNSVRRCLRDSLIKLKNRTIEYRDLDVEEFLQNVTLENFFNDFQDPENFKDIPNINLWCFLRNLSKFKAVKIRMLRHFSLCTPRTRYDWELLLKPVLRVNVPIEVRDKDGFVLYSYGQK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35PhosphorylationEGCADAKSLLHSTSH
CCCCCHHHHHHCCCC		37.5721440633
40PhosphorylationAKSLLHSTSHDIKSR
HHHHHHCCCCCHHHC		21.2321440633
41PhosphorylationKSLLHSTSHDIKSRS
HHHHHCCCCCHHHCC		23.3730377154
168PhosphorylationYSKFYNKSGQDSIIA
HHHHHCCCCCCCEEE		37.7430377154
182PhosphorylationAGSYKLDSYDKDVKK
EEEEECCCCCCCHHH		45.7430377154
282PhosphorylationITNEDLRTFQLSKKF
CCHHHHHHHHHCHHH		24.0319779198
411PhosphorylationFKMVKHLSLLKINSK
HHHHHHHHHHCCCCC		31.2321126336
458PhosphorylationSYYFQQRSLDTEDDF
EEEEEECCCCCCCCC		26.6830377154
470PhosphorylationDDFDDCNSMTETLFE
CCCCHHHHHHHHHCC		33.1530377154
594PhosphorylationTITSVDETDEDVGDE
HCCCCCCCCCCCCCC		39.9828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseSKP2P42843
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SKP2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SKP2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DMA2_YEASTDMA2physical
11805837
SKP1_YEASTSKP1physical
11805837
STI1_YEASTSTI1physical
11805837
UBI4P_YEASTUBI4physical
11805837
DMA1_YEASTDMA1physical
11805837
RUVB1_YEASTRVB1physical
11805837
ERG1_YEASTERG1physical
11805837
PRS4_YEASTRPT2physical
11805837
PRS10_YEASTRPT4physical
11805837
KAPS_YEASTMET14physical
10688190
SER33_YEASTSER33physical
10688190
KAPS_YEASTMET14physical
11283351
CSM1_YEASTCSM1physical
18719252
SER33_YEASTSER33physical
18719252
KAPS_YEASTMET14physical
18719252
CYS3_YEASTCYS3genetic
20936605
CBS_YEASTCYS4genetic
20936605
SKP2_YEASTSKP2physical
14747994
ADPP_YEASTYSA1genetic
27708008
VMA21_YEASTVMA21genetic
27708008
SIC1_YEASTSIC1genetic
27708008
CDS1_YEASTCDS1genetic
27708008
CALM_YEASTCMD1genetic
27708008
MPS1_YEASTMPS1genetic
27708008
SNU23_YEASTSNU23genetic
27708008
RRP42_YEASTRRP42genetic
27708008
CDC48_YEASTCDC48genetic
27708008
RPB1_YEASTRPO21genetic
27708008
PDC2_YEASTPDC2genetic
27708008
SEC1_YEASTSEC1genetic
27708008
PRP3_YEASTPRP3genetic
27708008
COG3_YEASTCOG3genetic
27708008
GNA1_YEASTGNA1genetic
27708008
ACT_YEASTACT1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
NBP35_YEASTNBP35genetic
27708008
PRP43_YEASTPRP43genetic
27708008
MCE1_YEASTCEG1genetic
27708008
RRP41_YEASTSKI6genetic
27708008
UTP9_YEASTUTP9genetic
27708008
ATC7_YEASTNEO1genetic
27708008
ESS1_YEASTESS1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
YKT6_YEASTYKT6genetic
27708008
BOS1_YEASTBOS1genetic
27708008
SMC4_YEASTSMC4genetic
27708008
NMT_YEASTNMT1genetic
27708008
SEC13_YEASTSEC13genetic
27708008
CDC3_YEASTCDC3genetic
27708008
AFG2_YEASTAFG2genetic
27708008
SEN1_YEASTSEN1genetic
27708008
VTI1_YEASTVTI1genetic
27708008
PRP24_YEASTPRP24genetic
27708008
LIP1_YEASTLIP1genetic
27708008
RPB2_YEASTRPB2genetic
27708008
CLP1_YEASTCLP1genetic
27708008
GPN2_YEASTGPN2genetic
27708008
NAB3_YEASTNAB3genetic
27708008
IF6_YEASTTIF6genetic
27708008
ARP7_YEASTARP7genetic
27708008
RPN7_YEASTRPN7genetic
27708008
SEC23_YEASTSEC23genetic
27708008
ATC3_YEASTDRS2genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
STE50_YEASTSTE50genetic
27708008
THRC_YEASTTHR4genetic
27708008
AIR2_YEASTAIR2genetic
27708008
SAC3_YEASTSAC3genetic
27708008
RTG2_YEASTRTG2genetic
27708008
CHO2_YEASTCHO2genetic
27708008
UGPA2_YEASTYHL012Wgenetic
27708008
LRP1_YEASTLRP1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
PAM17_YEASTPAM17genetic
27708008
NU133_YEASTNUP133genetic
27708008
YL012_YEASTYLR012Cgenetic
27708008
ERG3_YEASTERG3genetic
27708008
CSF1_YEASTCSF1genetic
27708008
METK1_YEASTSAM1genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
ADE_YEASTAAH1genetic
27708008
RTG1_YEASTRTG1genetic
27708008
RRP6_YEASTRRP6genetic
27708008
MGR2_YEASTMGR2genetic
27708008
UME1_YEASTUME1genetic
27708008
BEM4_YEASTBEM4genetic
27708008
CHMU_YEASTARO7genetic
27708008
MLH1_HUMANMLH1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SKP2_YEAST

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Related Literatures of Post-Translational Modification

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