| UniProt ID | MCE1_YEAST | |
|---|---|---|
| UniProt AC | Q01159 | |
| Protein Name | mRNA-capping enzyme subunit alpha | |
| Gene Name | CEG1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 459 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.. | |
| Protein Sequence | MVLAMESRVAPEIPGLIQPGNVTQDLKMMVCKLLNSPKPTKTFPGSQPVSFQHSDVEEKLLAHDYYVCEKTDGLRVLMFIVINPVTGEQGCFMIDRENNYYLVNGFRFPRLPQKKKEELLETLQDGTLLDGELVIQTNPMTKLQELRYLMFDCLAINGRCLTQSPTSSRLAHLGKEFFKPYFDLRAAYPNRCTTFPFKISMKHMDFSYQLVKVAKSLDKLPHLSDGLIFTPVKAPYTAGGKDSLLLKWKPEQENTVDFKLILDIPMVEDPSLPKDDRNRWYYNYDVKPVFSLYVWQGGADVNSRLKHFDQPFDRKEFEILERTYRKFAELSVSDEEWQNLKNLEQPLNGRIVECAKNQETGAWEMLRFRDDKLNGNHTSVVQKVLESINDSVSLEDLEEIVGDIKRCWDERRANMAGGSGRPLPSQSQNATLSTSKPVHSQPPSNDKEPKYVDEDDWSD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Phosphorylation | MVCKLLNSPKPTKTF HHHHHHCCCCCCCCC | 33.98 | 21440633 | |
| 70 | Acetylation | HDYYVCEKTDGLRVL CCEEEEECCCCCEEE | 46.95 | 24489116 | |
| 71 | Phosphorylation | DYYVCEKTDGLRVLM CEEEEECCCCCEEEE | 17.01 | 27017623 | |
| 164 | Phosphorylation | NGRCLTQSPTSSRLA CCEECCCCCCHHHHH | 25.55 | 21082442 | |
| 175 | Acetylation | SRLAHLGKEFFKPYF HHHHHHHHHHHHHHH | 58.68 | 24489116 | |
| 179 | Acetylation | HLGKEFFKPYFDLRA HHHHHHHHHHHCHHH | 44.09 | 24489116 | |
| 193 | Phosphorylation | AAYPNRCTTFPFKIS HHCCCCCCCCCEEEE | 28.38 | 28132839 | |
| 194 | Phosphorylation | AYPNRCTTFPFKISM HCCCCCCCCCEEEEE | 32.70 | 28132839 | |
| 200 | Phosphorylation | TTFPFKISMKHMDFS CCCCEEEEECCCCHH | 23.51 | 28132839 | |
| 241 | Acetylation | APYTAGGKDSLLLKW CCCCCCCCCCEEEEE | 43.13 | 24489116 | |
| 243 | Phosphorylation | YTAGGKDSLLLKWKP CCCCCCCCEEEEECC | 25.14 | 27017623 | |
| 247 | Acetylation | GKDSLLLKWKPEQEN CCCCEEEEECCCCCC | 53.81 | 24489116 | |
| 306 | Acetylation | ADVNSRLKHFDQPFD CCHHHHHHCCCCCCC | 40.91 | 24489116 | |
| 315 | Ubiquitination | FDQPFDRKEFEILER CCCCCCHHHHHHHHH | 69.47 | 24961812 | |
| 341 | Ubiquitination | DEEWQNLKNLEQPLN HHHHHHHHCCCCCCC | 68.02 | 24961812 | |
| 356 | Ubiquitination | GRIVECAKNQETGAW CCEEEHHHCCCCCCC | 71.47 | 23749301 | |
| 458 | Phosphorylation | YVDEDDWSD------ CCCCCCCCC------ | 40.20 | 22890988 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MCE1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MCE1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MCE1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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