TMC1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMC1_YEAST
• UniProt AC: Q08422
• Protein Name: AN1-type zinc finger protein TMC1 {ECO:0000305}
• Gene Name: TMC1 {ECO:0000303|PubMed:24297164}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 150
• Subcellular Localization: Nucleus .
• Protein Description: May have a role in protecting cells from metalloid-induced proteotoxicity..
• Protein Sequence: MSDINEIEIPSRKDEIRQVTPKDPMHEIEDKSTYHAKIKKSDSGTVLGAIPLNSRSSSNSSVTSTGQSSRRVTKKTTKKKKKNACYFDTCSSAASKFIGDCNFCKGHFCSKHRLMENHACNGLTSCKEQLHQRNADKLEAEQTKAPKIQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDINEIEI ------CCCCCCCCC		22814378
2	Phosphorylation	------MSDINEIEI ------CCCCCCCCC		22369663
11	Phosphorylation	INEIEIPSRKDEIRQ CCCCCCCCCHHHHCC		22369663
13	Acetylation	EIEIPSRKDEIRQVT CCCCCCCHHHHCCCC		24489116
20	Phosphorylation	KDEIRQVTPKDPMHE HHHHCCCCCCCCCCC		19823750
41	Phosphorylation	YHAKIKKSDSGTVLG EEEEEEECCCCCEEE		22369663
43	Phosphorylation	AKIKKSDSGTVLGAI EEEEECCCCCEEEEE		22369663
45	Phosphorylation	IKKSDSGTVLGAIPL EEECCCCCEEEEEEC		22369663
54	Phosphorylation	LGAIPLNSRSSSNSS EEEEECCCCCCCCCC		22369663
56	Phosphorylation	AIPLNSRSSSNSSVT EEECCCCCCCCCCCC		22890988
57	Phosphorylation	IPLNSRSSSNSSVTS EECCCCCCCCCCCCC		22890988
58	Phosphorylation	PLNSRSSSNSSVTST ECCCCCCCCCCCCCC		22369663
60	Phosphorylation	NSRSSSNSSVTSTGQ CCCCCCCCCCCCCCH		22890988
61	Phosphorylation	SRSSSNSSVTSTGQS CCCCCCCCCCCCCHH		22369663
63	Phosphorylation	SSSNSSVTSTGQSSR CCCCCCCCCCCHHHC		22890988
64	Phosphorylation	SSNSSVTSTGQSSRR CCCCCCCCCCHHHCC		22890988
65	Phosphorylation	SNSSVTSTGQSSRRV CCCCCCCCCHHHCCC		22890988
68	Phosphorylation	SVTSTGQSSRRVTKK CCCCCCHHHCCCCCC		22890988
69	Phosphorylation	VTSTGQSSRRVTKKT CCCCCHHHCCCCCCC		22890988
73	Phosphorylation	GQSSRRVTKKTTKKK CHHHCCCCCCCCCCC		19795423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMC1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMC1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMC1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YBF5_YEAST	YBL055C	physical	16554755
EIF3A_YEAST	RPG1	physical	16554755
SPT16_YEAST	SPT16	physical	16554755
CSK21_YEAST	CKA1	physical	16554755
EIF3C_YEAST	NIP1	physical	16554755
STU1_YEAST	STU1	genetic	27708008
KPC1_YEAST	PKC1	genetic	27708008
GPI18_YEAST	GPI18	genetic	27708008
PRP6_YEAST	PRP6	genetic	27708008
POP7_YEAST	POP7	genetic	27708008
APC11_YEAST	APC11	genetic	27708008
NSE4_YEAST	NSE4	genetic	27708008
CDC53_YEAST	CDC53	genetic	27708008
CDC37_YEAST	CDC37	genetic	27708008
TCPZ_YEAST	CCT6	genetic	27708008
RSP5_YEAST	RSP5	genetic	27708008
GNA1_YEAST	GNA1	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
RPN11_YEAST	RPN11	genetic	27708008
SMD1_YEAST	SMD1	genetic	27708008
TAF1_YEAST	TAF1	genetic	27708008
MED6_YEAST	MED6	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
YKT6_YEAST	YKT6	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
RU1C_YEAST	YHC1	genetic	27708008
AFG2_YEAST	AFG2	genetic	27708008
PGA3_YEAST	PGA3	genetic	27708008
GPI12_YEAST	GPI12	genetic	27708008
LCB1_YEAST	LCB1	genetic	27708008
CAP_YEAST	SRV2	genetic	27708008
RPC6_YEAST	RPC34	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.