| UniProt ID | PGA3_YEAST | |
|---|---|---|
| UniProt AC | Q12746 | |
| Protein Name | Plasma membrane-associated coenzyme Q6 reductase PGA3 | |
| Gene Name | PGA3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 312 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. Endoplasmic reticulum membrane Multi-pass membrane protein. |
|
| Protein Description | NADH-dependent cytochrome b5 reductase that reduces coenzyme Q6 at the plasma membrane and mediates lifespan extension by calorie restriction by shifting fermentative to respiratory metabolism, probably through modulating the NAD(+)/NADH ratio.. | |
| Protein Sequence | MSKEDIEGTNILDEPVHGIYIPAALFVVGVAITTYMSGELKILWSLPILFMIIFVRAYSAYKRRRSLYPDRWTSLELEDQTIISKNTALYRFKLKTRLESLDIPAGHHVAVRVPIDGKQEVRYYNPISSKLESGYLDLVVKAYVDGKVSKYFAGLNSGDTVDFKGPIGTLNYEPNSSKHLGIVAGGSGITPVLQILNEIITVPEDLTKVSLLYANETENDILLKDELDEMAEKYPHFQVHYVVHYPSDRWTGDVGYITKDQMNRYLPEYSEDNRLLICGPDGMNNLALQYAKELGWKVNSTRSSGDDQVFVF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 81 | Phosphorylation | SLELEDQTIISKNTA EEEECCCEEECCCCE | 32.38 | 24930733 | |
| 84 | Phosphorylation | LEDQTIISKNTALYR ECCCEEECCCCEEEE | 18.92 | 24930733 | |
| 157 | Phosphorylation | KYFAGLNSGDTVDFK HEEECCCCCCCEEEE | 42.99 | 21126336 | |
| 164 | Ubiquitination | SGDTVDFKGPIGTLN CCCCEEEECCCEECC | 60.35 | 23749301 | |
| 164 | Acetylation | SGDTVDFKGPIGTLN CCCCEEEECCCEECC | 60.35 | 24489116 | |
| 259 | Acetylation | GDVGYITKDQMNRYL CCEEEECHHHHHHCC | 36.08 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PGA3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PGA3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PGA3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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