| UniProt ID | EMC1_YEAST | |
|---|---|---|
| UniProt AC | P25574 | |
| Protein Name | ER membrane protein complex subunit 1 | |
| Gene Name | EMC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 760 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein . |
|
| Protein Description | The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).. | |
| Protein Sequence | MKITCTDLVYVFILLFLNTSCVQAVFSDDAFITDWQLANLGPWEKVIPDSRDRNRVLILSNPTETSCLVSSFNVSSGQILFRNVLPFTIDEIQLDSNDHNAMVCVNSSSNHWQKYDLHDWFLLEEGVDNAPSTTILPQSSYLNDQVSIKNNELHILDEQSKLAEWKLELPQGFNKVEYFHREDPLALVLNVNDTQYMGFSANGTELIPVWQRDEWLTNVVDYAVLDVFDSRDVELNKDMKAELDSNSLWNAYWLRLTTNWNRLINLLKENQFSPGRVFTKLLALDAKDTTVSDLKFGFAKILIVLTHDGFIGGLDMVNKGQLIWKLDLEIDQGVKMFWTDKNHDELVVFSHDGHYLTIEVTKDQPIIKSRSPLSERKTVDSVIRLNEHDHQYLIKFEDKDHLLFKLNPGKNTDVPIVANNHSSSHIFVTEHDTNGIYGYIIENDTVKQTWKKAVNSKEKMVAYSKRETTNLNTLGITLGDKSVLYKYLYPNLAAYLIANEEHHTITFNLIDTITGEILITQEHKDSPDFRFPMDIVFGEYWVVYSYFSSEPVPEQKLVVVELYESLTPDERLSNSSDNFSYDPLTGHINKPQFQTKQFIFPEIIKTMSISKTTDDITTKAIVMELENGQITYIPKLLLNARGKPAEEMAKDKKKEFMATPYTPVIPINDNFIITHFRNLLPGSDSQLISIPTNLESTSIICDLGLDVFCTRITPSGQFDLMSPTFEKGKLLITIFVLLVITYFIRPSVSNKKLKSQWLIK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 73 | N-linked_Glycosylation | SCLVSSFNVSSGQIL EEEEEEEEECCCEEE | 34.41 | - | |
| 106 | N-linked_Glycosylation | HNAMVCVNSSSNHWQ CCEEEEEECCCCCEE | 30.92 | - | |
| 161 | Acetylation | HILDEQSKLAEWKLE EEEECHHHHCCHHHH | 51.95 | 24489116 | |
| 166 | Acetylation | QSKLAEWKLELPQGF HHHHCCHHHHCCCCC | 24.48 | 24489116 | |
| 175 | Acetylation | ELPQGFNKVEYFHRE HCCCCCCEEEEEECC | 33.89 | 24489116 | |
| 192 | N-linked_Glycosylation | LALVLNVNDTQYMGF EEEEEECCCCCEEEE | 45.60 | - | |
| 202 | N-linked_Glycosylation | QYMGFSANGTELIPV CEEEEECCCCEEEEC | 57.64 | - | |
| 287 | Acetylation | KLLALDAKDTTVSDL HHHHCCCCCCCHHHH | 56.10 | 24489116 | |
| 290 | Phosphorylation | ALDAKDTTVSDLKFG HCCCCCCCHHHHHHC | 28.31 | 27017623 | |
| 292 | Phosphorylation | DAKDTTVSDLKFGFA CCCCCCHHHHHHCCE | 34.82 | 19779198 | |
| 399 | Acetylation | YLIKFEDKDHLLFKL EEEEECCCCEEEEEE | 39.59 | 24489116 | |
| 405 | Acetylation | DKDHLLFKLNPGKNT CCCEEEEEECCCCCC | 47.53 | 24489116 | |
| 420 | N-linked_Glycosylation | DVPIVANNHSSSHIF CCCEEEECCCCCEEE | 27.04 | - | |
| 443 | N-linked_Glycosylation | IYGYIIENDTVKQTW EEEEEEECHHHHHHH | 39.58 | - | |
| 463 | Phosphorylation | SKEKMVAYSKRETTN CHHHHEEEECCCCCC | 11.87 | 22890988 | |
| 464 | Phosphorylation | KEKMVAYSKRETTNL HHHHEEEECCCCCCC | 18.59 | 22890988 | |
| 481 | Acetylation | LGITLGDKSVLYKYL CCEEECCHHHHHHHH | 40.44 | 24489116 | |
| 574 | N-linked_Glycosylation | TPDERLSNSSDNFSY CCCHHHCCCCCCCCC | 50.56 | - | |
| 578 | N-linked_Glycosylation | RLSNSSDNFSYDPLT HHCCCCCCCCCCCCC | 29.70 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EMC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EMC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EMC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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