RRP4_YEAST - dbPTM
RRP4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RRP4_YEAST
UniProt AC P38792
Protein Name Exosome complex component RRP4
Gene Name RRP4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 359
Subcellular Localization Cytoplasm. Nucleus, nucleolus.
Protein Description Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP4 as peripheral part of the Exo-9 complex is thought to stabilize the hexameric ring of RNase PH-domain subunits..
Protein Sequence MSEVITITKRNGAFQNSSNLSYNNTGISDDENDEEDIYMHDVNSASKSESDSQIVTPGELVTDDPIWMRGHGTYFLDNMTYSSVAGTVSRVNRLLSVIPLKGRYAPETGDHVVGRIAEVGNKRWKVDIGGKQHAVLMLGSVNLPGGILRRKSESDELQMRSFLKEGDLLNAEVQSLFQDGSASLHTRSLKYGKLRNGMFCQVPSSLIVRAKNHTHNLPGNITVVLGVNGYIWLRKTSQMDLARDTPSANNSSSIKSTGPTGAVSLNPSITRLEEESSWQIYSDENDPSISNNIRQAICRYANVIKALAFCEIGITQQRIVSAYEASMVYSNVGELIEKNVMESIGSDILTAEKMRGNGN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSEVITITK
------CCCEEEEEE		40.3422814378
21PhosphorylationFQNSSNLSYNNTGIS
EECCCCCCCCCCCCC		30.0222369663
22PhosphorylationQNSSNLSYNNTGISD
ECCCCCCCCCCCCCC		18.6522369663
25PhosphorylationSNLSYNNTGISDDEN
CCCCCCCCCCCCCCC		32.0520377248
28PhosphorylationSYNNTGISDDENDEE
CCCCCCCCCCCCCHH		40.1122369663
38PhosphorylationENDEEDIYMHDVNSA
CCCHHCEEECCCCCC		10.7519779198
44PhosphorylationIYMHDVNSASKSESD
EEECCCCCCCCCCCC		33.4919779198
46PhosphorylationMHDVNSASKSESDSQ
ECCCCCCCCCCCCCC		36.2122369663
152PhosphorylationGGILRRKSESDELQM
CCEECCCCCCCHHHH		40.2928889911
154PhosphorylationILRRKSESDELQMRS
EECCCCCCCHHHHHH		43.4030377154
175PhosphorylationLLNAEVQSLFQDGSA
CCHHHHHHHHCCCCC		36.0122369663
236PhosphorylationGYIWLRKTSQMDLAR
CEEEEEECCCHHHCC		20.1125371407
237PhosphorylationYIWLRKTSQMDLARD
EEEEEECCCHHHCCC		26.9223749301
251PhosphorylationDTPSANNSSSIKSTG
CCCCCCCCCCCCCCC		25.8521440633
253PhosphorylationPSANNSSSIKSTGPT
CCCCCCCCCCCCCCC		33.5830377154
256PhosphorylationNNSSSIKSTGPTGAV
CCCCCCCCCCCCCCE		36.6121126336
260PhosphorylationSIKSTGPTGAVSLNP
CCCCCCCCCCEECCC		38.8330377154
264PhosphorylationTGPTGAVSLNPSITR
CCCCCCEECCCCCCE		23.1530377154
268PhosphorylationGAVSLNPSITRLEEE
CCEECCCCCCEECHH		35.2028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RRP4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RRP4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RRP4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RRP43_YEASTRRP43physical
9390555
RRP42_YEASTRRP42physical
9390555
RRP41_YEASTSKI6physical
9390555
RRP43_YEASTRRP43physical
16554755
RRP42_YEASTRRP42physical
16554755
RRP45_YEASTRRP45physical
16554755
LRP1_YEASTLRP1physical
16554755
RRP44_YEASTDIS3physical
16554755
RRP40_YEASTRRP40physical
16554755
RRP6_YEASTRRP6physical
16554755
CSL4_YEASTCSL4physical
16429126
RRP44_YEASTDIS3physical
16429126
LRP1_YEASTLRP1physical
16429126
MTR3_YEASTMTR3physical
16429126
RRP40_YEASTRRP40physical
16429126
RRP42_YEASTRRP42physical
16429126
RRP43_YEASTRRP43physical
16429126
RRP45_YEASTRRP45physical
16429126
RRP46_YEASTRRP46physical
16429126
RRP6_YEASTRRP6physical
16429126
RRP41_YEASTSKI6physical
16429126
SKI7_YEASTSKI7physical
16429126
RRP41_YEASTSKI6physical
17391830
RRP44_YEASTDIS3physical
17391830
MTR3_YEASTMTR3physical
17391830
RRP6_YEASTRRP6physical
17391830
SKI3_YEASTSKI3physical
18467557
RRP8_YEASTRRP8genetic
19061648
SEM1_YEASTSEM1genetic
19061648
THP2_YEASTTHP2genetic
19061648
NU120_YEASTNUP120genetic
19061648
LSM7_YEASTLSM7genetic
19061648
PHO23_YEASTPHO23genetic
19061648
TGS1_YEASTTGS1genetic
19061648
SSZ1_YEASTSSZ1physical
19536198
SSB1_YEASTSSB1physical
19536198
LSM6_YEASTLSM6genetic
27708008
DBF2_YEASTDBF2genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
YL407_YEASTYLR407Wgenetic
27708008
PFD4_YEASTGIM3genetic
27708008
LGE1_YEASTLGE1genetic
27708008
APC11_YEASTAPC11genetic
27708008
DAD1_YEASTDAD1genetic
27708008
ERF3_YEASTSUP35genetic
27708008
SPC19_YEASTSPC19genetic
27708008
TRS23_YEASTTRS23genetic
27708008
RRP45_YEASTRRP45genetic
27708008
RRP41_YEASTSKI6genetic
27708008
MTR4_YEASTMTR4genetic
27708008
NEP1_YEASTEMG1genetic
27708008
UTP13_YEASTUTP13genetic
27708008
NOP2_YEASTNOP2genetic
27708008
NAB3_YEASTNAB3genetic
27708008
NIP7_YEASTNIP7genetic
27708008
ATC3_YEASTDRS2genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
YPQ3_YEASTRTC2genetic
27708008
MCFS2_YEASTEHT1genetic
27708008
CS111_YEASTCOS111genetic
27708008
ISW1_YEASTISW1genetic
27708008
DPH7_YEASTRRT2genetic
27708008
PEX19_YEASTPEX19genetic
27708008
LRG1_YEASTLRG1genetic
27708008
RRP8_YEASTRRP8genetic
27708008
RPA14_YEASTRPA14genetic
27708008
PUF6_YEASTPUF6genetic
27708008
GNP1_YEASTGNP1genetic
27708008
GLRX4_YEASTGRX4genetic
27708008
UBP6_YEASTUBP6genetic
27708008
SGF73_YEASTSGF73genetic
27708008
CTU1_YEASTNCS6genetic
27708008
VAM7_YEASTVAM7genetic
27708008
URM1_YEASTURM1genetic
27708008
MET28_YEASTMET28genetic
27708008
MTC1_YEASTMTC1genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
PTK2_YEASTPTK2genetic
27708008
SAC1_YEASTSAC1genetic
27708008
SIS2_YEASTSIS2genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
IOC2_YEASTIOC2genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
SWC7_YEASTSWC7genetic
27708008
HRB1_YEASTHRB1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
CTU2_YEASTNCS2genetic
27708008
MPP6_YEASTMPP6genetic
27708008
RRP6_YEASTRRP6genetic
27708008
OST3_YEASTOST3genetic
27708008
RAD1_YEASTRAD1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
TBP6_YEASTYTA6genetic
27708008
MAGAB_HUMANMAGEA11physical
27107014
CEP76_HUMANCEP76physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RRP4_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-268, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory