MPP6_YEAST - dbPTM
MPP6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MPP6_YEAST
UniProt AC P53725
Protein Name M-phase phosphoprotein 6 homolog
Gene Name MPP6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 186
Subcellular Localization Nucleus . Colocalizes with the nuclear exosome and ribosomes.
Protein Description Involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA) derived from intergenic regions and the ribosomal DNA spacer heterochromatin. Binds RNA..
Protein Sequence MSANNGVTGKLSSRVMNMKFMKFGKTDDEESSNSNTPSNINSDVEPIEQKGKLFGLDDSAWDLNSYKDDLKKISGKEKKKVKRVVYKKRPNLIISNVGYSELRKPEGVISGRKTFGDNSDDSGSRKRKFDEGEQNEDEKRDAKDKEFTGSQDDGEDEYDLDKLFKDSIKKKKTNHNGKNKNRNSKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSANNGVTG
------CCCCCCCCC		39.4422814378
8PhosphorylationMSANNGVTGKLSSRV
CCCCCCCCCCHHHHH		29.9630377154
10AcetylationANNGVTGKLSSRVMN
CCCCCCCCHHHHHHH		35.5124489116
12PhosphorylationNGVTGKLSSRVMNMK
CCCCCCHHHHHHHHE		21.4230377154
13PhosphorylationGVTGKLSSRVMNMKF
CCCCCHHHHHHHHEE		39.0530377154
26PhosphorylationKFMKFGKTDDEESSN
EEEECCCCCCCCCCC		49.4122369663
31PhosphorylationGKTDDEESSNSNTPS
CCCCCCCCCCCCCCC		32.5422369663
32PhosphorylationKTDDEESSNSNTPSN
CCCCCCCCCCCCCCC		47.7822369663
34PhosphorylationDDEESSNSNTPSNIN
CCCCCCCCCCCCCCC		43.9922369663
36PhosphorylationEESSNSNTPSNINSD
CCCCCCCCCCCCCCC		28.1022369663
38PhosphorylationSSNSNTPSNINSDVE
CCCCCCCCCCCCCCC		48.5922369663
42PhosphorylationNTPSNINSDVEPIEQ
CCCCCCCCCCCCHHH		38.9622369663
59PhosphorylationKLFGLDDSAWDLNSY
CCCCCCCCCCCHHHH		30.8121440633
119PhosphorylationRKTFGDNSDDSGSRK
CCCCCCCCCCCCCCC		47.7523749301
122PhosphorylationFGDNSDDSGSRKRKF
CCCCCCCCCCCCCCC		43.5928889911
124PhosphorylationDNSDDSGSRKRKFDE
CCCCCCCCCCCCCCC		38.2827717283
128AcetylationDSGSRKRKFDEGEQN
CCCCCCCCCCCCCCC		61.2722865919
148PhosphorylationDAKDKEFTGSQDDGE
HHHHHCCCCCCCCCC		36.6922369663
150PhosphorylationKDKEFTGSQDDGEDE
HHHCCCCCCCCCCCC		27.6425521595
158PhosphorylationQDDGEDEYDLDKLFK
CCCCCCCCCHHHHHH		33.8425521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MPP6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MPP6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MPP6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RRP45_YEASTRRP45physical
16554755
DDI1_YEASTDDI1physical
16554755
RRP4_YEASTRRP4physical
16554755
LRP1_YEASTLRP1physical
16554755
CSL4_YEASTCSL4physical
16554755
RRP6_YEASTRRP6physical
16554755
RRP42_YEASTRRP42physical
16554755
NOP3_YEASTNPL3genetic
19061648
DBP3_YEASTDBP3genetic
19061648
PAP2_YEASTPAP2genetic
19061648
AIR1_YEASTAIR1genetic
19061648
PUB1_YEASTPUB1genetic
19061648
LRP1_YEASTLRP1genetic
19061648
POP8_YEASTPOP8genetic
19061648
POP7_YEASTPOP7genetic
19061648
BRR1_YEASTBRR1genetic
19061648
CHD1_YEASTCHD1genetic
19061648
RRP43_YEASTRRP43physical
18591258
RRP44_YEASTDIS3physical
18591258
RRP6_YEASTRRP6physical
18591258
RRP4_YEASTRRP4physical
18591258
MTR3_YEASTMTR3physical
18591258
RRP45_YEASTRRP45physical
18591258
CSL4_YEASTCSL4physical
18591258
RRP41_YEASTSKI6physical
18591258
RRP40_YEASTRRP40physical
18591258
RRP46_YEASTRRP46physical
18591258
RRP42_YEASTRRP42physical
18591258
LRP1_YEASTLRP1physical
18591258
MTR4_YEASTMTR4physical
18591258
AIR2_YEASTAIR2physical
18591258
PAP2_YEASTPAP2physical
18591258
AIR1_YEASTAIR1physical
18591258
DED1_YEASTDED1physical
18591258
DBP5_YEASTDBP5physical
18591258
RRP5_YEASTRRP5physical
18591258
NOP56_YEASTNOP56physical
18591258
RL8B_YEASTRPL8Bphysical
18591258
RL4A_YEASTRPL4Aphysical
18591258
PABP_YEASTPAB1physical
18591258
NRD1_YEASTNRD1physical
18591258
RRP6_YEASTRRP6genetic
24224060
MED10_YEASTNUT2genetic
27708008
LCF1_YEASTFAA1genetic
27708008
CDC27_YEASTCDC27genetic
27708008
CDK1_YEASTCDC28genetic
27708008
APC11_YEASTAPC11genetic
27708008
USO1_YEASTUSO1genetic
27708008
RRP42_YEASTRRP42genetic
27708008
LCB2_YEASTLCB2genetic
27708008
ERF3_YEASTSUP35genetic
27708008
RRP45_YEASTRRP45genetic
27708008
FCF1_YEASTFCF1genetic
27708008
RPB7_YEASTRPB7genetic
27708008
UTP6_YEASTUTP6genetic
27708008
RMRP_YEASTSNM1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
SWC4_YEASTSWC4genetic
27708008
RRP41_YEASTSKI6genetic
27708008
RRP4_YEASTRRP4genetic
27708008
NU159_YEASTNUP159genetic
27708008
MTR4_YEASTMTR4genetic
27708008
ESS1_YEASTESS1genetic
27708008
NUP85_YEASTNUP85genetic
27708008
BET5_YEASTBET5genetic
27708008
ERB1_YEASTERB1genetic
27708008
BRX1_YEASTBRX1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
YTM1_YEASTYTM1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
SHG1_YEASTSHG1genetic
27708008
RPN4_YEASTRPN4genetic
27708008
MNN10_YEASTMNN10genetic
27708008
VAM7_YEASTVAM7genetic
27708008
SLX9_YEASTSLX9genetic
27708008
DBF2_YEASTDBF2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
MCR1_YEASTMCR1genetic
27708008
SRL3_YEASTSRL3genetic
27708008
MMM1_YEASTMMM1genetic
27708008
COA4_YEASTCOA4genetic
27708008
ROM2_YEASTROM2genetic
27708008
AIM34_YEASTAIM34genetic
27708008
COQ10_YEASTCOQ10genetic
27708008
HMI1_YEASTHMI1genetic
27708008
MCH4_YEASTMCH4genetic
27708008
RRP6_YEASTRRP6genetic
27708008
COQ7_YEASTCAT5genetic
27708008
MSC6_YEASTMSC6genetic
27708008
SUR1_YEASTSUR1genetic
27708008
NEW1_YEASTNEW1genetic
27708008
RRP6_YEASTRRP6physical
27076633
NRD1_YEASTNRD1physical
27076633
RRP6_YEASTRRP6genetic
27076633
PAP2_YEASTPAP2genetic
27076633
RRP6_YEASTRRP6genetic
28742025
RRP6_YEASTRRP6physical
28877463
RRP43_YEASTRRP43physical
28877463
RRP4_YEASTRRP4physical
28877463
CSL4_YEASTCSL4physical
28877463
RRP45_YEASTRRP45physical
28877463
RRP42_YEASTRRP42physical
28877463
RRP46_YEASTRRP46physical
28877463
RRP41_YEASTSKI6physical
28877463
RRP40_YEASTRRP40physical
28877463
MTR3_YEASTMTR3physical
28877463
LRP1_YEASTLRP1physical
28877463
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MPP6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; THR-148 AND SER-150,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-150, AND MASSSPECTROMETRY.

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