| UniProt ID | NOP56_YEAST | |
|---|---|---|
| UniProt AC | Q12460 | |
| Protein Name | Nucleolar protein 56 | |
| Gene Name | NOP56 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 504 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Required for 60S ribosomal subunit synthesis.. | |
| Protein Sequence | MAPIEYLLFEEPTGYAVFKVKLQQDDIGSRLKEVQEQINDFGAFTKLIELVSFAPFKGAAEALENANDISEGLVSESLKAILDLNLPKASSKKKNITLAISDKNLGPSIKEEFPYVDCISNELAQDLIRGVRLHGEKLFKGLQSGDLERAQLGLGHAYSRAKVKFSVQKNDNHIIQAIALLDQLDKDINTFAMRVKEWYGWHFPELAKLVPDNYTFAKLVLFIKDKASLNDDSLHDLAALLNEDSGIAQRVIDNARISMGQDISETDMENVCVFAQRVASLADYRRQLYDYLCEKMHTVAPNLSELIGEVIGARLISHAGSLTNLSKQAASTVQILGAEKALFRALKTKGNTPKYGLIYHSGFISKASAKNKGRISRYLANKCSMASRIDNYSEEPSNVFGSVLKKQVEQRLEFYNTGKPTLKNELAIQEAMELYNKDKPAAEVEETKEKESSKKRKLEDDDEEKKEKKEKKSKKEKKEKKEKKDKKEKKDKKEKKDKKKKSKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Ubiquitination | PTGYAVFKVKLQQDD CCCEEEEEEEECCCC | 31.68 | 17644757 | |
| 21 | Acetylation | GYAVFKVKLQQDDIG CEEEEEEEECCCCHH | 40.96 | 24489116 | |
| 21 | Ubiquitination | GYAVFKVKLQQDDIG CEEEEEEEECCCCHH | 40.96 | 17644757 | |
| 32 | Acetylation | DDIGSRLKEVQEQIN CCHHHHHHHHHHHHC | 55.52 | 24489116 | |
| 32 | Ubiquitination | DDIGSRLKEVQEQIN CCHHHHHHHHHHHHC | 55.52 | 17644757 | |
| 46 | Ubiquitination | NDFGAFTKLIELVSF CCCHHHHHHHHHHHC | 40.80 | 17644757 | |
| 57 | Ubiquitination | LVSFAPFKGAAEALE HHHCCCCCCHHHHHH | 46.73 | 17644757 | |
| 79 | Ubiquitination | GLVSESLKAILDLNL CHHCHHHHHHHCCCC | 42.53 | 17644757 | |
| 88 | Ubiquitination | ILDLNLPKASSKKKN HHCCCCCCCCCCCCC | 65.16 | 15699485 | |
| 94 | Ubiquitination | PKASSKKKNITLAIS CCCCCCCCCEEEEEC | 58.27 | 15699485 | |
| 103 | Ubiquitination | ITLAISDKNLGPSIK EEEEECCCCCCCCHH | 47.48 | 17644757 | |
| 103 | Acetylation | ITLAISDKNLGPSIK EEEEECCCCCCCCHH | 47.48 | 24489116 | |
| 110 | Ubiquitination | KNLGPSIKEEFPYVD CCCCCCHHHHCCCHH | 56.37 | 17644757 | |
| 137 | Ubiquitination | GVRLHGEKLFKGLQS HHHHHHHHHHHCCCC | 64.91 | 22817900 | |
| 137 | Acetylation | GVRLHGEKLFKGLQS HHHHHHHHHHHCCCC | 64.91 | 24489116 | |
| 140 | Ubiquitination | LHGEKLFKGLQSGDL HHHHHHHHCCCCCCH | 69.97 | 24961812 | |
| 140 | Succinylation | LHGEKLFKGLQSGDL HHHHHHHHCCCCCCH | 69.97 | 23954790 | |
| 140 | Acetylation | LHGEKLFKGLQSGDL HHHHHHHHCCCCCCH | 69.97 | 24489116 | |
| 144 | Phosphorylation | KLFKGLQSGDLERAQ HHHHCCCCCCHHHHH | 39.04 | 25752575 | |
| 159 | Phosphorylation | LGLGHAYSRAKVKFS HCCCCCCCCCEEEEE | 26.92 | 28889911 | |
| 164 | Ubiquitination | AYSRAKVKFSVQKND CCCCCEEEEEECCCC | 31.08 | 17644757 | |
| 164 | Acetylation | AYSRAKVKFSVQKND CCCCCEEEEEECCCC | 31.08 | 25381059 | |
| 169 | Ubiquitination | KVKFSVQKNDNHIIQ EEEEEECCCCCHHHH | 65.20 | 17644757 | |
| 186 | Ubiquitination | ALLDQLDKDINTFAM HHHHHHCCCHHHHHH | 69.93 | 17644757 | |
| 190 | Phosphorylation | QLDKDINTFAMRVKE HHCCCHHHHHHHHHH | 17.07 | 19795423 | |
| 196 | Ubiquitination | NTFAMRVKEWYGWHF HHHHHHHHHHHCCCC | 31.97 | 17644757 | |
| 208 | Ubiquitination | WHFPELAKLVPDNYT CCCHHHHHHCCCCCH | 63.74 | 17644757 | |
| 208 | Acetylation | WHFPELAKLVPDNYT CCCHHHHHHCCCCCH | 63.74 | 24489116 | |
| 218 | Ubiquitination | PDNYTFAKLVLFIKD CCCCHHHHHHHHHHC | 34.63 | 17644757 | |
| 224 | 2-Hydroxyisobutyrylation | AKLVLFIKDKASLND HHHHHHHHCCCCCCC | 45.93 | - | |
| 224 | Ubiquitination | AKLVLFIKDKASLND HHHHHHHHCCCCCCC | 45.93 | 17644757 | |
| 224 | Acetylation | AKLVLFIKDKASLND HHHHHHHHCCCCCCC | 45.93 | 24489116 | |
| 226 | Ubiquitination | LVLFIKDKASLNDDS HHHHHHCCCCCCCCC | 34.57 | 17644757 | |
| 295 | Ubiquitination | LYDYLCEKMHTVAPN HHHHHHHHHHHHCCC | 34.68 | 17644757 | |
| 317 | Phosphorylation | VIGARLISHAGSLTN HHHHHHHHCHHHCHH | 16.33 | 23749301 | |
| 321 | Phosphorylation | RLISHAGSLTNLSKQ HHHHCHHHCHHHHHH | 32.57 | 17563356 | |
| 323 | Phosphorylation | ISHAGSLTNLSKQAA HHCHHHCHHHHHHHH | 35.49 | 29136822 | |
| 326 | Phosphorylation | AGSLTNLSKQAASTV HHHCHHHHHHHHHHH | 25.45 | 30377154 | |
| 327 | Ubiquitination | GSLTNLSKQAASTVQ HHCHHHHHHHHHHHH | 47.31 | 23749301 | |
| 331 | Phosphorylation | NLSKQAASTVQILGA HHHHHHHHHHHHHCH | 31.93 | 22369663 | |
| 332 | Phosphorylation | LSKQAASTVQILGAE HHHHHHHHHHHHCHH | 16.23 | 22369663 | |
| 340 | Ubiquitination | VQILGAEKALFRALK HHHHCHHHHHHHHHH | 50.27 | 23749301 | |
| 340 | Acetylation | VQILGAEKALFRALK HHHHCHHHHHHHHHH | 50.27 | 24489116 | |
| 348 | Phosphorylation | ALFRALKTKGNTPKY HHHHHHHCCCCCCCE | 45.06 | 27017623 | |
| 354 | Acetylation | KTKGNTPKYGLIYHS HCCCCCCCEEEEEEC | 50.33 | 24489116 | |
| 354 | Ubiquitination | KTKGNTPKYGLIYHS HCCCCCCCEEEEEEC | 50.33 | 17644757 | |
| 355 | Phosphorylation | TKGNTPKYGLIYHSG CCCCCCCEEEEEECC | 20.54 | 27214570 | |
| 361 | Phosphorylation | KYGLIYHSGFISKAS CEEEEEECCCCCHHH | 20.58 | 21440633 | |
| 365 | Phosphorylation | IYHSGFISKASAKNK EEECCCCCHHHHCCC | 21.65 | 28889911 | |
| 366 | Ubiquitination | YHSGFISKASAKNKG EECCCCCHHHHCCCH | 41.36 | 23749301 | |
| 366 | Acetylation | YHSGFISKASAKNKG EECCCCCHHHHCCCH | 41.36 | 25381059 | |
| 376 | Phosphorylation | AKNKGRISRYLANKC HCCCHHHHHHHHHHC | 17.32 | 19684113 | |
| 382 | Ubiquitination | ISRYLANKCSMASRI HHHHHHHHCCHHHCC | 23.29 | 23749301 | |
| 382 | Acetylation | ISRYLANKCSMASRI HHHHHHHHCCHHHCC | 23.29 | 25381059 | |
| 393 | Phosphorylation | ASRIDNYSEEPSNVF HHCCCCCCCCCCCCH | 41.56 | 27214570 | |
| 397 | Phosphorylation | DNYSEEPSNVFGSVL CCCCCCCCCCHHHHH | 49.24 | 27017623 | |
| 402 | Phosphorylation | EPSNVFGSVLKKQVE CCCCCHHHHHHHHHH | 16.89 | 30377154 | |
| 405 | Ubiquitination | NVFGSVLKKQVEQRL CCHHHHHHHHHHHHH | 38.72 | 17644757 | |
| 405 | Acetylation | NVFGSVLKKQVEQRL CCHHHHHHHHHHHHH | 38.72 | 24489116 | |
| 406 | Ubiquitination | VFGSVLKKQVEQRLE CHHHHHHHHHHHHHH | 56.25 | 17644757 | |
| 419 | Ubiquitination | LEFYNTGKPTLKNEL HHHHHCCCCCHHHHH | 32.56 | 24961812 | |
| 419 | Acetylation | LEFYNTGKPTLKNEL HHHHHCCCCCHHHHH | 32.56 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NOP56_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOP56_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOP56_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND THR-323, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, AND MASSSPECTROMETRY. | |
