REXO4_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REXO4_YEAST
• UniProt AC: Q08237
• Protein Name: RNA exonuclease 4
• Gene Name: REX4
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 289
• Subcellular Localization: Nucleus .
• Protein Description: Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs..
• Protein Sequence: MALSSNWQALLASESNPTSNGKNKQSNRKIRNVKKVSKTVNVSSTTQYAPRKRKNGSKIMDMVYNMNKEISKHEKDKLEGKVFEFNPNKANTSTTIKEPVKVGISEDTRINSNKSKEIGKYIAMDCEFVGVGPEGKESALARISIVNYFGHVVLDEFVKPREKVVEWRTWVSGIKPEHMKNAITFKEAQKKTADILEGRILVGHALKHDLEALMLSHPKSLLRDTSRHLPFRKLYAKGKTPSLKKLTREVLKISIQEGEHSSVEDARATMLLYKKEKTEFEKIHRNTFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	LASESNPTSNGKNKQ HHCCCCCCCCCCCHH	38.79	29650682
19	Phosphorylation	ASESNPTSNGKNKQS HCCCCCCCCCCCHHH	44.86	29650682
39	Phosphorylation	NVKKVSKTVNVSSTT CCCEEEEEECCCCCC	15.14	19779198
43	Phosphorylation	VSKTVNVSSTTQYAP EEEEECCCCCCCCCC	19.43	19779198
58	Acetylation	RKRKNGSKIMDMVYN CCCCCCCCHHHHHHH	43.37	25381059
64	Phosphorylation	SKIMDMVYNMNKEIS CCHHHHHHHHCHHHH	11.32	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REXO4_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REXO4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REXO4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RLI1_YEAST	RLI1	genetic	19061648
DBP3_YEAST	DBP3	genetic	19061648
MRH4_YEAST	MRH4	genetic	19061648
DOA1_YEAST	DOA1	genetic	19061648
PAP2_YEAST	PAP2	genetic	19061648
NOP12_YEAST	NOP12	genetic	19061648
RRP6_YEAST	RRP6	genetic	19061648
GBLP_YEAST	ASC1	genetic	19061648
SAP30_YEAST	SAP30	genetic	19061648
TMA23_YEAST	TMA23	genetic	19061648
PIH1_YEAST	PIH1	genetic	19061648
SSF1_YEAST	SSF1	genetic	19061648
NOP16_YEAST	NOP16	genetic	19061648
NTC20_YEAST	NTC20	genetic	19061648
IF2A_YEAST	SUI2	genetic	19061648
HIR2_YEAST	HIR2	genetic	19061648
HRB1_YEAST	HRB1	genetic	19061648
SSB1_YEAST	SSB1	physical	19536198
CSG2_YEAST	CSG2	genetic	20093466
BIT2_YEAST	BIT2	genetic	20093466
DBP3_YEAST	DBP3	genetic	20093466
PIH1_YEAST	PIH1	genetic	20093466
SSF1_YEAST	SSF1	genetic	20093466
LST4_YEAST	LST4	genetic	20093466
FEN1_YEAST	RAD27	genetic	20093466
SRP40_YEAST	SRP40	genetic	20093466
MMM1_YEAST	MMM1	genetic	20093466
TMA23_YEAST	TMA23	genetic	20093466
YO223_YEAST	DSC3	genetic	20093466
MAK16_YEAST	MAK16	genetic	27708008
MAK5_YEAST	MAK5	genetic	27708008
MAK21_YEAST	MAK21	genetic	27708008
DBP9_YEAST	DBP9	genetic	27708008
RU1C_YEAST	YHC1	genetic	27708008
RLP7_YEAST	RLP7	genetic	27708008
NOP2_YEAST	NOP2	genetic	27708008
ATC3_YEAST	DRS2	genetic	27708008
DBP3_YEAST	DBP3	genetic	27708008
CHO2_YEAST	CHO2	genetic	27708008
PIH1_YEAST	PIH1	genetic	27708008
FEN1_YEAST	RAD27	genetic	27708008
LST4_YEAST	LST4	genetic	27708008
SRP40_YEAST	SRP40	genetic	27708008
MMM1_YEAST	MMM1	genetic	27708008
GBLP_YEAST	ASC1	genetic	27708008
TMA23_YEAST	TMA23	genetic	27708008
YOR31_YEAST	YOR131C	genetic	27708008
YO223_YEAST	DSC3	genetic	27708008
GPB1_YEAST	GPB1	genetic	27708008
FUMH_YEAST	FUM1	genetic	27708008
PPAL_YEAST	LTP1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.