PPAL_YEAST - dbPTM
PPAL_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPAL_YEAST
UniProt AC P40347
Protein Name Low molecular weight phosphotyrosine protein phosphatase
Gene Name LTP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 161
Subcellular Localization Cytoplasm.
Protein Description Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates..
Protein Sequence MTIEKPKISVAFICLGNFCRSPMAEAIFKHEVEKANLENRFNKIDSFGTSNYHVGESPDHRTVSICKQHGVKINHKGKQIKTKHFDEYDYIIGMDESNINNLKKIQPEGSKAKVCLFGDWNTNDGTVQTIIEDPWYGDIQDFEYNFKQITYFSKQFLKKEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Ubiquitination-MTIEKPKISVAFIC
-CCCCCCCEEEEEEE		59.6917644757
29AcetylationPMAEAIFKHEVEKAN
HHHHHHHHHHHHHHC		32.5122865919
34AcetylationIFKHEVEKANLENRF
HHHHHHHHHCHHHHH		47.9924489116
43UbiquitinationNLENRFNKIDSFGTS
CHHHHHHHCCCCCCC		45.2217644757
43AcetylationNLENRFNKIDSFGTS
CHHHHHHHCCCCCCC		45.2224489116
50PhosphorylationKIDSFGTSNYHVGES
HCCCCCCCCCCCCCC		35.4528889911
57PhosphorylationSNYHVGESPDHRTVS
CCCCCCCCCCCCCCH		29.6920377248
62PhosphorylationGESPDHRTVSICKQH
CCCCCCCCCHHHHHH		18.3821551504
64PhosphorylationSPDHRTVSICKQHGV
CCCCCCCHHHHHHCC		22.9621551504
67UbiquitinationHRTVSICKQHGVKIN
CCCCHHHHHHCCEEC		43.5923749301
81UbiquitinationNHKGKQIKTKHFDEY
CCCCCCCCCCCCCCC		49.3717644757
83UbiquitinationKGKQIKTKHFDEYDY
CCCCCCCCCCCCCCE		36.9517644757
83AcetylationKGKQIKTKHFDEYDY
CCCCCCCCCCCCCCE		36.9524489116
103UbiquitinationESNINNLKKIQPEGS
HHHHCCCCCCCCCCC		50.3717644757
104UbiquitinationSNINNLKKIQPEGSK
HHHCCCCCCCCCCCC		50.1417644757
154AcetylationKQITYFSKQFLKKEL
HHHHHHHHHHHHHCC		34.8624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPAL_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPAL_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPAL_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MOT1_YEASTMOT1physical
11805837
FKBP3_YEASTFPR3physical
15358193
RTG3_YEASTRTG3genetic
19269370
VAC14_YEASTVAC14genetic
19269370
ADA2_YEASTADA2genetic
21127252
ACE2_YEASTACE2genetic
21127252
HAL4_YEASTSAT4genetic
21127252
HAA1_YEASTHAA1genetic
21127252
ASK10_YEASTASK10genetic
27708008
PTK2_YEASTPTK2genetic
27708008
SAC1_YEASTSAC1genetic
27708008
VPS9_YEASTVPS9genetic
27708008
RAD14_YEASTRAD14genetic
27708008
MKS1_YEASTMKS1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
MSC6_YEASTMSC6genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPAL_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-57, AND MASSSPECTROMETRY.

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