| UniProt ID | RTG3_YEAST | |
|---|---|---|
| UniProt AC | P38165 | |
| Protein Name | Retrograde regulation protein 3 | |
| Gene Name | RTG3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 486 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcription factor that regulates CIT2 gene expression. Binds to two identical sites oriented as inverted repeats 28 bp apart in a regulatory upstream activation sequence element (UASR) in the CIT2 promoter. The core binding site is 5'-GGTCAC-3'.. | |
| Protein Sequence | MMNNNESEAENQRLLDELMNQTKVLQETLDFSLVTPTPHHNDDYKIHGSAYPGGETPAQQHEKLSYINTHNSNDNNNLMGSQARSNSQTPTASTIYEEAESQSSYLDDMFRTSQGGRPVTQNSISSIGQGPLRSSYSMAYDSPVDRAMNTPLQQQEGLKAELPHDFLFQHGTDDTMYNLTDDLSSSLSSSINSDMMTPNTYSSSFSYNPQSLGPASVSSTYSPKVRSPSSSFRAGSFLSSSFRHGSINTPRTRHTSISSNMTENIGPGSVPKILGGLTSDEKLRRKREFHNAVERRRRELIKQKIKELGQLVPPSLLNYDDLGKQIKPNKGIILDRTVEYLQYLAEILEIQARKKKALLAKIKELEEKKSSVAALSPFTNNHHASSGQNNSENSEERIIDIRSVPNALMNEQNSKAELHNWEPPLYDSVGNHNHAGTMESHPHTNIHEELKEFLSGDLIEAEDNAKLMFGDDNSNPADYLLEFGSG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MMNNNESEAENQRL -CCCCCHHHHHHHHH | 44.20 | 28132839 | |
| 22 | Phosphorylation | LDELMNQTKVLQETL HHHHHHHHHHHHHHC | 20.37 | 27017623 | |
| 32 | Phosphorylation | LQETLDFSLVTPTPH HHHHCCCEECCCCCC | 22.92 | 24961812 | |
| 35 | Phosphorylation | TLDFSLVTPTPHHND HCCCEECCCCCCCCC | 27.09 | 24961812 | |
| 37 | Phosphorylation | DFSLVTPTPHHNDDY CCEECCCCCCCCCCC | 26.36 | 24961812 | |
| 51 | Phosphorylation | YKIHGSAYPGGETPA CCCCCCCCCCCCCHH | 12.24 | 21440633 | |
| 56 | Phosphorylation | SAYPGGETPAQQHEK CCCCCCCCHHHHHHH | 27.48 | 25005228 | |
| 69 | Phosphorylation | EKLSYINTHNSNDNN HHHHEECCCCCCCCC | 16.93 | 28889911 | |
| 72 | Phosphorylation | SYINTHNSNDNNNLM HEECCCCCCCCCCCC | 37.65 | 23749301 | |
| 81 | Phosphorylation | DNNNLMGSQARSNSQ CCCCCCCCHHHCCCC | 13.50 | 28889911 | |
| 85 | Phosphorylation | LMGSQARSNSQTPTA CCCCHHHCCCCCCCH | 43.80 | 30377154 | |
| 87 | Phosphorylation | GSQARSNSQTPTAST CCHHHCCCCCCCHHH | 36.36 | 28889911 | |
| 89 | Phosphorylation | QARSNSQTPTASTIY HHHCCCCCCCHHHHH | 23.56 | 21440633 | |
| 91 | Phosphorylation | RSNSQTPTASTIYEE HCCCCCCCHHHHHHH | 36.31 | 30377154 | |
| 93 | Phosphorylation | NSQTPTASTIYEEAE CCCCCCHHHHHHHHH | 20.16 | 30377154 | |
| 96 | Phosphorylation | TPTASTIYEEAESQS CCCHHHHHHHHHHHC | 14.06 | 30377154 | |
| 104 | Phosphorylation | EEAESQSSYLDDMFR HHHHHHCHHHHHHHH | 23.29 | 30377154 | |
| 112 | Phosphorylation | YLDDMFRTSQGGRPV HHHHHHHHCCCCCCC | 17.71 | 30377154 | |
| 113 | Phosphorylation | LDDMFRTSQGGRPVT HHHHHHHCCCCCCCC | 23.67 | 28889911 | |
| 120 | Phosphorylation | SQGGRPVTQNSISSI CCCCCCCCCCCCCCC | 25.39 | 22369663 | |
| 123 | Phosphorylation | GRPVTQNSISSIGQG CCCCCCCCCCCCCCC | 17.65 | 22369663 | |
| 125 | Phosphorylation | PVTQNSISSIGQGPL CCCCCCCCCCCCCCC | 18.74 | 22369663 | |
| 126 | Phosphorylation | VTQNSISSIGQGPLR CCCCCCCCCCCCCCC | 29.12 | 22369663 | |
| 134 | Phosphorylation | IGQGPLRSSYSMAYD CCCCCCCCCCHHCCC | 41.11 | 22890988 | |
| 135 | Phosphorylation | GQGPLRSSYSMAYDS CCCCCCCCCHHCCCC | 18.13 | 22890988 | |
| 136 | Phosphorylation | QGPLRSSYSMAYDSP CCCCCCCCHHCCCCH | 12.05 | 22890988 | |
| 137 | Phosphorylation | GPLRSSYSMAYDSPV CCCCCCCHHCCCCHH | 10.01 | 22890988 | |
| 140 | Phosphorylation | RSSYSMAYDSPVDRA CCCCHHCCCCHHHHH | 14.33 | 22890988 | |
| 142 | Phosphorylation | SYSMAYDSPVDRAMN CCHHCCCCHHHHHHC | 17.72 | 22369663 | |
| 150 | Phosphorylation | PVDRAMNTPLQQQEG HHHHHHCCHHHHHCC | 16.58 | 22369663 | |
| 221 | Phosphorylation | PASVSSTYSPKVRSP CCCCCCCCCCCCCCC | 25.56 | 28889911 | |
| 222 | Phosphorylation | ASVSSTYSPKVRSPS CCCCCCCCCCCCCCC | 20.52 | 28889911 | |
| 227 | Phosphorylation | TYSPKVRSPSSSFRA CCCCCCCCCCCCCCC | 31.92 | 21082442 | |
| 229 | Phosphorylation | SPKVRSPSSSFRAGS CCCCCCCCCCCCCCC | 39.60 | 22890988 | |
| 230 | Phosphorylation | PKVRSPSSSFRAGSF CCCCCCCCCCCCCCC | 36.56 | 22890988 | |
| 231 | Phosphorylation | KVRSPSSSFRAGSFL CCCCCCCCCCCCCCC | 24.08 | 21082442 | |
| 236 | Phosphorylation | SSSFRAGSFLSSSFR CCCCCCCCCCCCCCC | 23.25 | 22369663 | |
| 239 | Phosphorylation | FRAGSFLSSSFRHGS CCCCCCCCCCCCCCC | 23.17 | 22890988 | |
| 240 | Phosphorylation | RAGSFLSSSFRHGSI CCCCCCCCCCCCCCC | 35.33 | 22890988 | |
| 241 | Phosphorylation | AGSFLSSSFRHGSIN CCCCCCCCCCCCCCC | 23.95 | 22369663 | |
| 246 | Phosphorylation | SSSFRHGSINTPRTR CCCCCCCCCCCCCCC | 13.41 | 25005228 | |
| 249 | Phosphorylation | FRHGSINTPRTRHTS CCCCCCCCCCCCCCC | 16.69 | 23749301 | |
| 255 | Phosphorylation | NTPRTRHTSISSNMT CCCCCCCCCCCCCCC | 25.19 | 19684113 | |
| 256 | Phosphorylation | TPRTRHTSISSNMTE CCCCCCCCCCCCCCC | 17.85 | 28152593 | |
| 258 | Phosphorylation | RTRHTSISSNMTENI CCCCCCCCCCCCCCC | 18.54 | 19684113 | |
| 259 | Phosphorylation | TRHTSISSNMTENIG CCCCCCCCCCCCCCC | 29.02 | 19684113 | |
| 262 | Phosphorylation | TSISSNMTENIGPGS CCCCCCCCCCCCCCC | 30.08 | 19684113 | |
| 269 | Phosphorylation | TENIGPGSVPKILGG CCCCCCCCCCHHHCC | 38.08 | 25704821 | |
| 278 | Phosphorylation | PKILGGLTSDEKLRR CHHHCCCCCHHHHHH | 37.09 | 28152593 | |
| 279 | Phosphorylation | KILGGLTSDEKLRRK HHHCCCCCHHHHHHH | 49.14 | 28152593 | |
| 370 | Phosphorylation | KELEEKKSSVAALSP HHHHHHHCCCEECCC | 40.90 | 29136822 | |
| 371 | Phosphorylation | ELEEKKSSVAALSPF HHHHHHCCCEECCCC | 25.34 | 29136822 | |
| 376 | Phosphorylation | KSSVAALSPFTNNHH HCCCEECCCCCCCCC | 17.16 | 25005228 | |
| 379 | Phosphorylation | VAALSPFTNNHHASS CEECCCCCCCCCCCC | 38.20 | 29136822 | |
| 385 | Phosphorylation | FTNNHHASSGQNNSE CCCCCCCCCCCCCCC | 30.55 | 29136822 | |
| 386 | Phosphorylation | TNNHHASSGQNNSEN CCCCCCCCCCCCCCC | 45.22 | 28132839 | |
| 394 | Phosphorylation | GQNNSENSEERIIDI CCCCCCCCCHHHEEH | 36.46 | 27214570 | |
| 455 | Phosphorylation | EELKEFLSGDLIEAE HHHHHHHCCCCEEEH | 35.27 | 28152593 | |
| 474 | Phosphorylation | LMFGDDNSNPADYLL EEECCCCCCHHHHHH | 51.70 | 24961812 | |
| 479 | Phosphorylation | DNSNPADYLLEFGSG CCCCHHHHHHHCCCC | 18.45 | 24961812 | |
| 485 | Phosphorylation | DYLLEFGSG------ HHHHHCCCC------ | 46.80 | 28152593 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RTG3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RTG3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RTG3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; SER-113; SER-123;SER-126; SER-135; TYR-140; SER-142; THR-150; TYR-221; SER-222;SER-227; SER-236 AND SER-279, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123 AND SER-142, ANDMASS SPECTROMETRY. | |
