| UniProt ID | GAL4_YEAST | |
|---|---|---|
| UniProt AC | P04386 | |
| Protein Name | Regulatory protein GAL4 | |
| Gene Name | GAL4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 881 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | This protein is a positive regulator for the gene expression of the galactose-induced genes such as GAL1, GAL2, GAL7, GAL10, and MEL1 which code for the enzymes used to convert galactose to glucose. It recognizes a 17 base pair sequence in (5'-CGGRNNRCYNYNCNCCG-3') the upstream activating sequence (UAS-G) of these genes.. | |
| Protein Sequence | MKLLSSIEQACDICRLKKLKCSKEKPKCAKCLKNNWECRYSPKTKRSPLTRAHLTEVESRLERLEQLFLLIFPREDLDMILKMDSLQDIKALLTGLFVQDNVNKDAVTDRLASVETDMPLTLRQHRISATSSSEESSNKGQRQLTVSIDSAAHHDNSTIPLDFMPRDALHGFDWSEEDDMSDGLPFLKTDPNNNGFFGDGSLLCILRSIGFKPENYTNSNVNRLPTMITDRYTLASRSTTSRLLQSYLNNFHPYCPIVHSPTLMMLYNNQIEIASKDQWQILFNCILAIGAWCIEGESTDIDVFYYQNAKSHLTSKVFESGSIILVTALHLLSRYTQWRQKTNTSYNFHSFSIRMAISLGLNRDLPSSFSDSSILEQRRRIWWSVYSWEIQLSLLYGRSIQLSQNTISFPSSVDDVQRTTTGPTIYHGIIETARLLQVFTKIYELDKTVTAEKSPICAKKCLMICNEIEEVSRQAPKFLQMDISTTALTNLLKEHPWLSFTRFELKWKQLSLIIYVLRDFFTNFTQKKSQLEQDQNDHQSYEVKRCSIMLSDAAQRTVMSVSSYMDNHNVTPYFAWNCSYYLFNAVLVPIKTLLSNSKSNAENNETAQLLQQINTVLMLLKKLATFKIQTCEKYIQVLEEVCAPFLLSQCAIPLPHISYNNSNGSAIKNIVGSATIAQYPTLPEENVNNISVKYVSPGSVGPSPVPLKSGASFSDLVKLLSNRPPSRNSPVTIPRSTPSHRSVTPFLGQQQQLQSLVPLTPSALFGGANFNQSGNIADSSLSFTFTNSSNGPNLITTQTNSQALSQPIASSNVHDNFMNNEITASKIDDGNNSKPLSPGWTDQTAYNAFGITTGMFNTTTMDDVYNYLFDDEDTPPNPKKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 130 | Phosphorylation | RQHRISATSSSEESS EHHEEECCCCCHHHC | 23.50 | 27017623 | |
| 131 | Phosphorylation | QHRISATSSSEESSN HHEEECCCCCHHHCC | 31.42 | 27017623 | |
| 132 | Phosphorylation | HRISATSSSEESSNK HEEECCCCCHHHCCC | 37.10 | 28889911 | |
| 133 | Phosphorylation | RISATSSSEESSNKG EEECCCCCHHHCCCC | 45.19 | 27017623 | |
| 136 | Phosphorylation | ATSSSEESSNKGQRQ CCCCCHHHCCCCCEE | 34.85 | 28889911 | |
| 137 | Phosphorylation | TSSSEESSNKGQRQL CCCCHHHCCCCCEEE | 45.93 | 27017623 | |
| 691 | Phosphorylation | EENVNNISVKYVSPG HHHCCCEEEEEECCC | 18.06 | 28889911 | |
| 694 | Phosphorylation | VNNISVKYVSPGSVG CCCEEEEEECCCCCC | 12.19 | 28889911 | |
| 696 | Phosphorylation | NISVKYVSPGSVGPS CEEEEEECCCCCCCC | 22.06 | 28889911 | |
| 699 | Phosphorylation | VKYVSPGSVGPSPVP EEEECCCCCCCCCCC | 27.56 | 28889911 | |
| 703 | Phosphorylation | SPGSVGPSPVPLKSG CCCCCCCCCCCCCCC | 32.38 | 28889911 | |
| 709 | Phosphorylation | PSPVPLKSGASFSDL CCCCCCCCCCCHHHH | 47.47 | 28889911 | |
| 712 | Phosphorylation | VPLKSGASFSDLVKL CCCCCCCCHHHHHHH | 28.89 | 22369663 | |
| 714 | Phosphorylation | LKSGASFSDLVKLLS CCCCCCHHHHHHHHH | 27.78 | 21440633 | |
| 837 | Phosphorylation | GNNSKPLSPGWTDQT CCCCCCCCCCCCCCH | 29.87 | 28889911 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GAL4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GAL4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-712, AND MASSSPECTROMETRY. | |
