| UniProt ID | EPL1_YEAST | |
|---|---|---|
| UniProt AC | P43572 | |
| Protein Name | Enhancer of polycomb-like protein 1 | |
| Gene Name | EPL1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 832 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.. | |
| Protein Sequence | MPTPSNAIEINDGSHKSGRSTRRSGSRSAHDDGLDSFSKGDSGAGASAGSSNSRFRHRKISVKQHLKIYLPNDLKHLDKDELQQREVVEIETGVEKNEEKEVHLHRILQMGSGHTKHKDYIPTPDASMTWNEYDKFYTGSFQETTSYIKFSATVEDCCGTNYNMDERDETFLNEQVNKGSSDILTEDEFEILCSSFEHAIHERQPFLSMDPESILSFEELKPTLIKSDMADFNLRNQLNHEINSHKTHFITQFDPVSQMNTRPLIQLIEKFGSKIYDYWRERKIEVNGYEIFPQLKFERPGEKEEIDPYVCFRRREVRHPRKTRRIDILNSQRLRALHQELKNAKDLALLVAKRENVSLNWINDELKIFDQRVKIKNLKRSLNISGEDDDLINHKRKRPTIVTVEQREAELRKAELKRAAAAAAAAKAKNNKRNNQLEDKSSRLTKQQQQQLLQQQQQQQQNALKTENGKQLANASSSSTSQPITSHVYVKLPSSKIPDIVLEDVDALLNSKEKNARKFVQEKMEKRKIEDADVFFNLTDDPFNPVFDMSLPKNFSTSNVPFASIASSKFQIDRSFYSSHLPEYLKGISDDIRIYDSNGRSRNKDNYNLDTKRIKKTELYDPFQENLEIHSREYPIKFRKRVGRSNIKYVDRMPNFTTSSTKSACSLMDFVDFDSIEKEQYSREGSNDTDSINVYDSKYDEFVRLYDKWKYDSPQNEYGIKFSDEPARLNQISNDTQVIRFGTMLGTKSYEQLREATIKYRRDYITRLKQKHIQHLQQQQQQQQQQQQQAQQQKQKSQNNNSNSSNSLKKLNDSLINSEAKQNSSITQKNSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MPTPSNAIEI -----CCCCCCCEEC | 37.74 | 28132839 | |
| 14 | Phosphorylation | AIEINDGSHKSGRST CEECCCCCCCCCCCC | 30.52 | 28132839 | |
| 16 | Acetylation | EINDGSHKSGRSTRR ECCCCCCCCCCCCCC | 57.19 | 23572591 | |
| 17 | Phosphorylation | INDGSHKSGRSTRRS CCCCCCCCCCCCCCC | 33.73 | 28132839 | |
| 20 | Phosphorylation | GSHKSGRSTRRSGSR CCCCCCCCCCCCCCC | 29.77 | 28132839 | |
| 21 | Phosphorylation | SHKSGRSTRRSGSRS CCCCCCCCCCCCCCC | 28.83 | 28132839 | |
| 28 | Phosphorylation | TRRSGSRSAHDDGLD CCCCCCCCCCCCCCC | 31.49 | 30377154 | |
| 36 | Phosphorylation | AHDDGLDSFSKGDSG CCCCCCCCCCCCCCC | 36.14 | 30377154 | |
| 39 | Acetylation | DGLDSFSKGDSGAGA CCCCCCCCCCCCCCC | 65.80 | 24489116 | |
| 42 | Phosphorylation | DSFSKGDSGAGASAG CCCCCCCCCCCCCCC | 38.93 | 17563356 | |
| 47 | Phosphorylation | GDSGAGASAGSSNSR CCCCCCCCCCCCCCC | 32.04 | 19823750 | |
| 50 | Phosphorylation | GAGASAGSSNSRFRH CCCCCCCCCCCCCCC | 26.51 | 19823750 | |
| 51 | Phosphorylation | AGASAGSSNSRFRHR CCCCCCCCCCCCCCC | 37.60 | 17563356 | |
| 53 | Phosphorylation | ASAGSSNSRFRHRKI CCCCCCCCCCCCCCC | 34.44 | 19823750 | |
| 61 | Phosphorylation | RFRHRKISVKQHLKI CCCCCCCCHHHHHEE | 26.71 | 19823750 | |
| 63 | Acetylation | RHRKISVKQHLKIYL CCCCCCHHHHHEEEC | 25.80 | 25381059 | |
| 75 | Acetylation | IYLPNDLKHLDKDEL EECCCCHHCCCHHHH | 45.01 | 24489116 | |
| 96 | Acetylation | EIETGVEKNEEKEVH EEECCCCCCCCHHEH | 68.22 | 23572591 | |
| 100 | Acetylation | GVEKNEEKEVHLHRI CCCCCCCHHEHHHHH | 59.88 | 23572591 | |
| 116 | Acetylation | QMGSGHTKHKDYIPT HCCCCCCCCCCCCCC | 42.88 | 23572591 | |
| 118 | Acetylation | GSGHTKHKDYIPTPD CCCCCCCCCCCCCCC | 54.50 | 23572591 | |
| 345 | Acetylation | HQELKNAKDLALLVA HHHHHCHHHHHHHHH | 63.77 | 24489116 | |
| 353 | Acetylation | DLALLVAKRENVSLN HHHHHHHCCCCCCCC | 53.41 | 24489116 | |
| 376 | Acetylation | FDQRVKIKNLKRSLN HHHHHHHHHHHHHHC | 50.97 | 23572591 | |
| 379 | Acetylation | RVKIKNLKRSLNISG HHHHHHHHHHHCCCC | 49.70 | 23572591 | |
| 395 | Acetylation | DDDLINHKRKRPTIV CCHHHCCCCCCCEEE | 55.94 | 23572591 | |
| 427 | Acetylation | AAAAAAAKAKNNKRN HHHHHHHHHHHCHHC | 55.99 | 22865919 | |
| 429 | Acetylation | AAAAAKAKNNKRNNQ HHHHHHHHHCHHCHH | 61.42 | 23572591 | |
| 441 | Phosphorylation | NNQLEDKSSRLTKQQ CHHHHHHHHHHHHHH | 32.77 | 27017623 | |
| 442 | Phosphorylation | NQLEDKSSRLTKQQQ HHHHHHHHHHHHHHH | 36.73 | 27017623 | |
| 445 | Phosphorylation | EDKSSRLTKQQQQQL HHHHHHHHHHHHHHH | 26.20 | 27017623 | |
| 446 | Acetylation | DKSSRLTKQQQQQLL HHHHHHHHHHHHHHH | 51.18 | 23572591 | |
| 470 | Acetylation | ALKTENGKQLANASS HHHCHHHHHHHCCCC | 54.44 | 23572591 | |
| 496 | Acetylation | YVKLPSSKIPDIVLE EEECCCCCCCCCHHH | 63.70 | 23572591 | |
| 512 | Acetylation | VDALLNSKEKNARKF HHHHHCCCHHHHHHH | 72.18 | 24489116 | |
| 569 | Acetylation | FASIASSKFQIDRSF CHHHHCCCCCCCHHH | 38.50 | 24489116 | |
| 604 | Acetylation | SNGRSRNKDNYNLDT CCCCCCCCCCCCCCC | 46.36 | 24489116 | |
| 611 | Phosphorylation | KDNYNLDTKRIKKTE CCCCCCCCHHCCCCC | 25.95 | 27017623 | |
| 648 | Ubiquitination | RVGRSNIKYVDRMPN HCCCCCCEEEECCCC | 43.39 | 23749301 | |
| 648 | Acetylation | RVGRSNIKYVDRMPN HCCCCCCEEEECCCC | 43.39 | 25381059 | |
| 663 | Phosphorylation | FTTSSTKSACSLMDF CCCCCCCHHHHHHHH | 34.30 | 27017623 | |
| 686 | Phosphorylation | EQYSREGSNDTDSIN HHHCCCCCCCCCCEE | 27.12 | 28889911 | |
| 721 | Acetylation | PQNEYGIKFSDEPAR CCCCCCEECCCCCHH | 34.16 | 23572591 | |
| 804 | Phosphorylation | SQNNNSNSSNSLKKL HHHCCCCCHHHHHHH | 30.62 | 28889911 | |
| 805 | Phosphorylation | QNNNSNSSNSLKKLN HHCCCCCHHHHHHHH | 34.39 | 30377154 | |
| 807 | Phosphorylation | NNSNSSNSLKKLNDS CCCCCHHHHHHHHHH | 43.44 | 28889911 | |
| 809 | Acetylation | SNSSNSLKKLNDSLI CCCHHHHHHHHHHHC | 55.85 | 25381059 | |
| 814 | Phosphorylation | SLKKLNDSLINSEAK HHHHHHHHHCCHHHH | 30.03 | 30377154 | |
| 821 | Acetylation | SLINSEAKQNSSITQ HHCCHHHHHCCCCCC | 46.06 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EPL1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EPL1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EPL1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-51, AND MASSSPECTROMETRY. | |
