| UniProt ID | SGPL_YEAST | |
|---|---|---|
| UniProt AC | Q05567 | |
| Protein Name | Sphingosine-1-phosphate lyase | |
| Gene Name | DPL1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 589 | |
| Subcellular Localization | ||
| Protein Description | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine.. | |
| Protein Sequence | MSGVSNKTVSINGWYGMPIHLLREEGDFAQFMILTINELKIAIHGYLRNTPWYNMLKDYLFVIFCYKLISNFFYLLKVYGPVRLAVRTYEHSSRRLFRWLLDSPFLRGTVEKEVTKVKQSIEDELIRSDSQLMNFPQLPSNGIPQDDVIEELNKLNDLIPHTQWKEGKVSGAVYHGGDDLIHLQTIAYEKYCVANQLHPDVFPAVRKMESEVVSMVLRMFNAPSDTGCGTTTSGGTESLLLACLSAKMYALHHRGITEPEIIAPVTAHAGFDKAAYYFGMKLRHVELDPTTYQVDLGKVKKFINKNTILLVGSAPNFPHGIADDIEGLGKIAQKYKLPLHVDSCLGSFIVSFMEKAGYKNLPLLDFRVPGVTSISCDTHKYGFAPKGSSVIMYRNSDLRMHQYYVNPAWTGGLYGSPTLAGSRPGAIVVGCWATMVNMGENGYIESCQEIVGAAMKFKKYIQENIPDLNIMGNPRYSVISFSSKTLNIHELSDRLSKKGWHFNALQKPVALHMAFTRLSAHVVDEICDILRTTVQELKSESNSKPSPDGTSALYGVAGSVKTAGVADKLIVGFLDALYKLGPGEDTATK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | N-linked_Glycosylation | --MSGVSNKTVSING --CCCCCCCEEEECC | 41.43 | - | |
| 103 | Phosphorylation | LFRWLLDSPFLRGTV HHHHHHCCHHHCCCC | 19.95 | 27017623 | |
| 109 | Phosphorylation | DSPFLRGTVEKEVTK CCHHHCCCCHHHHHH | 21.03 | 27017623 | |
| 115 | Phosphorylation | GTVEKEVTKVKQSIE CCCHHHHHHHHHHHH | 31.08 | 27017623 | |
| 120 | Phosphorylation | EVTKVKQSIEDELIR HHHHHHHHHHHHHHC | 23.40 | 30377154 | |
| 128 | Phosphorylation | IEDELIRSDSQLMNF HHHHHHCCCHHHCCC | 34.32 | 30377154 | |
| 162 | Phosphorylation | LNDLIPHTQWKEGKV HHHCCCCCCCCCCCC | 30.67 | 19795423 | |
| 168 | Ubiquitination | HTQWKEGKVSGAVYH CCCCCCCCCEEEEEE | 34.03 | 17644757 | |
| 190 | Ubiquitination | LQTIAYEKYCVANQL EEEEHHHCHHHHHCC | 31.13 | 17644757 | |
| 207 | Ubiquitination | DVFPAVRKMESEVVS CCHHHHHHHHHHHHH | 40.18 | 17644757 | |
| 273 | Ubiquitination | TAHAGFDKAAYYFGM EECCCCHHHHHHHCC | 32.43 | 17644757 | |
| 281 | Ubiquitination | AAYYFGMKLRHVELD HHHHHCCEEEEEEEC | 42.63 | 17644757 | |
| 298 | Ubiquitination | TYQVDLGKVKKFINK EEEEEHHHHHHHCCC | 59.17 | 17644757 | |
| 298 | Acetylation | TYQVDLGKVKKFINK EEEEEHHHHHHHCCC | 59.17 | 24489116 | |
| 305 | Ubiquitination | KVKKFINKNTILLVG HHHHHCCCCEEEEEC | 51.13 | 17644757 | |
| 330 | Ubiquitination | DDIEGLGKIAQKYKL HCCCCHHHHHHHHCC | 39.65 | 17644757 | |
| 359 | Ubiquitination | FMEKAGYKNLPLLDF HHHHCCCCCCCCCCE | 51.60 | 17644757 | |
| 380 | Ubiquitination | SISCDTHKYGFAPKG EEEECCCCCCCCCCC | 49.51 | 17644757 | |
| 380 | N6-(pyridoxal phosphate)lysine | SISCDTHKYGFAPKG EEEECCCCCCCCCCC | 49.51 | - | |
| 380 | Other | SISCDTHKYGFAPKG EEEECCCCCCCCCCC | 49.51 | - | |
| 380 | Acetylation | SISCDTHKYGFAPKG EEEECCCCCCCCCCC | 49.51 | 24489116 | |
| 381 | Phosphorylation | ISCDTHKYGFAPKGS EEECCCCCCCCCCCC | 15.18 | 27017623 | |
| 386 | Acetylation | HKYGFAPKGSSVIMY CCCCCCCCCCEEEEE | 68.91 | 24489116 | |
| 388 | Phosphorylation | YGFAPKGSSVIMYRN CCCCCCCCEEEEEEC | 27.79 | 27017623 | |
| 393 | Phosphorylation | KGSSVIMYRNSDLRM CCCEEEEEECCCCCE | 8.77 | 27017623 | |
| 458 | Ubiquitination | VGAAMKFKKYIQENI HHHHHHHHHHHHHCC | 38.87 | 17644757 | |
| 459 | Ubiquitination | GAAMKFKKYIQENIP HHHHHHHHHHHHCCC | 51.20 | 24961812 | |
| 484 | Ubiquitination | SVISFSSKTLNIHEL EEEEEECCCCCHHHH | 56.70 | 17644757 | |
| 485 | Phosphorylation | VISFSSKTLNIHELS EEEEECCCCCHHHHH | 27.30 | 27017623 | |
| 492 | Phosphorylation | TLNIHELSDRLSKKG CCCHHHHHHHHHHCC | 20.07 | 27017623 | |
| 497 | Ubiquitination | ELSDRLSKKGWHFNA HHHHHHHHCCCCCHH | 60.95 | 17644757 | |
| 498 | Ubiquitination | LSDRLSKKGWHFNAL HHHHHHHCCCCCHHH | 64.95 | 17644757 | |
| 561 | Ubiquitination | YGVAGSVKTAGVADK HHHHHCCCHHCCCHH | 34.06 | 17644757 | |
| 568 | Ubiquitination | KTAGVADKLIVGFLD CHHCCCHHHHHHHHH | 30.31 | 17644757 | |
| 579 | Ubiquitination | GFLDALYKLGPGEDT HHHHHHHHHCCCCCC | 48.06 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SGPL_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SGPL_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SGPL_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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