YRM1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YRM1_YEAST
• UniProt AC: Q12340
• Protein Name: Zinc finger transcription factor YRM1
• Gene Name: YRM1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 786
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Transcription factor involved in the regulation of multidrug resistance genes. Acts in concert with YRR1..
• Protein Sequence: MSKRGSLQDRASPSEETVKKAQKRRKPIKSCAFCRKRKLRCDQQKPMCSTCKTRGRSGCLYTEKFTHKIETKELFGSTPNIELLKRIEDLEKRLDDKELTEKDVALSTSPFRNPYANFYYLQCKGSGRRIVYGPTSLRTHLSNDDNRFVNTYNQLWSKVKIERNRWKARHKWTMKPETQLLEGPPLEKTGSDILQQVCNVLPSFEQSSKIITDFFNTELETNEVSEVLDKTKIINDFTSSFLPSDELLPNGERRIEKLLPSTKKNYYKIGVILMILCIRHFYKNTPEEIEKFLIMLTGLSTAKVYFIERAQFLLLKYYHRELIWACGDDSHMISLVDLLCSTAIMLGLHLNIREIYKNQENIVGSMESLENLWVWIILSDFNVSLNIGRCLAINSSYFQVDECENGERLPKNTNNYSSTVFFDQSNSCMGKLKRFLRLARPMLDQIYDRSAFPDLAENCKKLRNFVETEFHPISYYTDSELISKVPLCEIKVLAQVLNLLLTFYSLRYLIYKEKSVVLENNILQTILVSFSLVINTTILCFNLDEKHFPEFFDHNCVHLPPFMALSLVYTNFLFPRASTGFCAFLYHKLTLFEKGYYLSSNIKDQEVTDWDLSTLNIPLDKAMNLLTAFKIHSDIFAKWSNDNNKQLRIIMARSYTFVINIALESIYRAVLEKVIKYRTEVENTWLQQLQDELNGSYSLTDNVNTPIDPSLSDLGVTSASPLAGNSPGLPPEEVRNNSENASHNNETGPIETELAQTISNEFWTAYNLGWEELMSQPDYKYLFDTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSKRGSLQDRASP --CCCCCCCCCCCCC	27.22	21440633
12	Phosphorylation	GSLQDRASPSEETVK CCCCCCCCCCHHHHH	29.83	25752575
14	Phosphorylation	LQDRASPSEETVKKA CCCCCCCCHHHHHHH	45.64	24961812
77	Phosphorylation	ETKELFGSTPNIELL EHHHHHCCCCCHHHH	33.10	27214570
78	Phosphorylation	TKELFGSTPNIELLK HHHHHCCCCCHHHHH	22.27	27214570
100	Phosphorylation	RLDDKELTEKDVALS HCCCCCCCHHHHHHC	41.92	27017623
108	Phosphorylation	EKDVALSTSPFRNPY HHHHHHCCCCCCCCC	41.07	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YRM1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YRM1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YRM1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HMO1_YEAST	HMO1	physical	16554755
CIK1_YEAST	CIK1	genetic	17314980
ODPA_YEAST	PDA1	genetic	17314980
YPT6_YEAST	YPT6	genetic	17314980
SSB1_YEAST	SSB1	physical	19536198
CSN9_YEAST	CSN9	genetic	27708008
NEM1_YEAST	NEM1	genetic	27708008
MAS5_YEAST	YDJ1	genetic	27708008
BIOA_YEAST	BIO3	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77, AND MASSSPECTROMETRY.
PubMed: 18407956