BIOA_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BIOA_YEAST
• UniProt AC: P50277
• Protein Name: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
• Gene Name: BIO3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 480
• Protein Description: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor..
• Protein Sequence: MSQEISYTPDVAELLDFDKKHIWHPYTSLSSPLNVYPVKSAHGCKLVLDTDSPVDVEVIDAMSSWWCVIHGYNNPELNEALTKQMLKFSHVLLGGFTHKGAVNLVQKLLKVIDEPSLQYCFLADSGSVAVEVALKMALQSNMSGEATKNRTKFLTIKNGYHGDTFGAMSVCDPENSMHHIYNDRLSENIFAQAPSIVDGLPTSQNGFEDHWNAEEVTDLKKQFELHSDKICAVILEPILQGAGGLRPYHPQFLIEVQKLCNQYDVLFIMDEIATGFGRTGEIFAFKHCQKYQDQHGISPSDQIKVVPDILCVGKGLTSGYMTMSAVVVNDKVASRISSPNSPTGGCFMHGPTFMGNALACSVAEKSMDILLRGEWRKQVSAIENQIYRELYQYIKNPDNGLIGTVVKRVSVIGAVGIVELYKKTDPEWFQKKFISKGVHIRPFNCLCYIMPPYVITTEELTKVNQVLIEVLHEWKSHINQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQEISYTP ------CCCCCCCCC	36.20	22369663
314	N6-(pyridoxal phosphate)lysine	PDILCVGKGLTSGYM CCEEEECCCCCCCCC	30.28	-
314	Other	PDILCVGKGLTSGYM CCEEEECCCCCCCCC	30.28	-
341	Phosphorylation	SRISSPNSPTGGCFM HCCCCCCCCCCCCCC	27.50	23749301
343	Phosphorylation	ISSPNSPTGGCFMHG CCCCCCCCCCCCCCC	46.13	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BIOA_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BIOA_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BIOA_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UAP1_YEAST	QRI1	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
ORC1_YEAST	ORC1	genetic	27708008
MCM1_YEAST	MCM1	genetic	27708008
ROT1_YEAST	ROT1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.