| UniProt ID | ORC1_YEAST | |
|---|---|---|
| UniProt AC | P54784 | |
| Protein Name | Origin recognition complex subunit 1 | |
| Gene Name | ORC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 914 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication.. | |
| Protein Sequence | MAKTLKDLQGWEIITTDEQGNIIDGGQKRLRRRGAKTEHYLKRSSDGIKLGRGDSVVMHNEAAGTYSVYMIQELRLNTLNNVVELWALTYLRWFEVNPLAHYRQFNPDANILNRPLNYYNKLFSETANKNELYLTAELAELQLFNFIRVANVMDGSKWEVLKGNVDPERDFTVRYICEPTGEKFVDINIEDVKAYIKKVEPREAQEYLKDLTLPSKKKEIKRGPQKKDKATQTAQISDAETRATDITDNEDGNEDESSDYESPSDIDVSEDMDSGEISADELEEEEDEEEDEDEEEKEARHTNSPRKRGRKIKLGKDDIDASVQPPPKKRGRKPKDPSKPRQMLLISSCRANNTPVIRKFTKKNVARAKKKYTPFSKRFKSIAAIPDLTSLPEFYGNSSELMASRFENKLKTTQKHQIVETIFSKVKKQLNSSYVKEEILKSANFQDYLPARENEFASIYLSAYSAIESDSATTIYVAGTPGVGKTLTVREVVKELLSSSAQREIPDFLYVEINGLKMVKPTDCYETLWNKVSGERLTWAASMESLEFYFKRVPKNKKKTIVVLLDELDAMVTKSQDIMYNFFNWTTYENAKLIVIAVANTMDLPERQLGNKITSRIGFTRIMFTGYTHEELKNIIDLRLKGLNDSFFYVDTKTGNAILIDAAGNDTTVKQTLPEDVRKVRLRMSADAIEIASRKVASVSGDARRALKVCKRAAEIAEKHYMAKHGYGYDGKTVIEDENEEQIYDDEDKDLIESNKAKDDNDDDDDNDGVQTVHITHVMKALNETLNSHVITFMTRLSFTAKLFIYALLNLMKKNGSQEQELGDIVDEIKLLIEVNGSNKFVMEIAKTLFQQGSDNISEQLRIISWDFVLNQLLDAGILFKQTMKNDRICCVKLNISVEEAKRAMNEDETLRNL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Acetylation | KRSSDGIKLGRGDSV HHCCCCCEECCCCEE | 50.87 | 25381059 | |
| 156 | Phosphorylation | VANVMDGSKWEVLKG EEECCCCCCEEEECC | 30.26 | 28889911 | |
| 231 | Phosphorylation | PQKKDKATQTAQISD CCCCCCCCCEEECCC | 31.99 | 22890988 | |
| 233 | Phosphorylation | KKDKATQTAQISDAE CCCCCCCEEECCCHH | 19.04 | 22890988 | |
| 237 | Phosphorylation | ATQTAQISDAETRAT CCCEEECCCHHHHCC | 20.77 | 22369663 | |
| 241 | Phosphorylation | AQISDAETRATDITD EECCCHHHHCCCCCC | 27.59 | 22890988 | |
| 304 | Phosphorylation | KEARHTNSPRKRGRK HHHHHCCCCCCCCCC | 27.51 | 28889911 | |
| 322 | Phosphorylation | GKDDIDASVQPPPKK CCCCCCCCCCCCCCC | 19.96 | 27214570 | |
| 381 | Phosphorylation | PFSKRFKSIAAIPDL CHHHHHHHHHCCCCC | 18.10 | 28889911 | |
| 389 | Phosphorylation | IAAIPDLTSLPEFYG HHCCCCCCCCCHHHC | 35.28 | 28889911 | |
| 390 | Phosphorylation | AAIPDLTSLPEFYGN HCCCCCCCCCHHHCC | 49.58 | 28889911 | |
| 395 | Phosphorylation | LTSLPEFYGNSSELM CCCCCHHHCCHHHHH | 17.46 | 28889911 | |
| 398 | Phosphorylation | LPEFYGNSSELMASR CCHHHCCHHHHHHHH | 22.33 | 28889911 | |
| 685 | Phosphorylation | RKVRLRMSADAIEIA HHHHHHHCHHHHHHH | 19.30 | 28889911 | |
| 693 | Phosphorylation | ADAIEIASRKVASVS HHHHHHHHHHHHHCC | 37.99 | 28889911 | |
| 719 | Acetylation | RAAEIAEKHYMAKHG HHHHHHHHHHHHHCC | 30.89 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ORC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ORC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ORC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND MASSSPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND MASSSPECTROMETRY. | |