ADT2_YEAST - dbPTM
ADT2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADT2_YEAST
UniProt AC P18239
Protein Name ADP,ATP carrier protein 2
Gene Name PET9
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 318
Subcellular Localization Mitochondrion inner membrane
Multi-pass membrane protein .
Protein Description Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane..
Protein Sequence MSSNAQVKTPLPPAPAPKKESNFLIDFLMGGVSAAVAKTAASPIERVKLLIQNQDEMLKQGTLDRKYAGILDCFKRTATQEGVISFWRGNTANVIRYFPTQALNFAFKDKIKAMFGFKKEEGYAKWFAGNLASGGAAGALSLLFVYSLDYARTRLAADSKSSKKGGARQFNGLIDVYKKTLKSDGVAGLYRGFLPSVVGIVVYRGLYFGMYDSLKPLLLTGSLEGSFLASFLLGWVVTTGASTCSYPLDTVRRRMMMTSGQAVKYDGAFDCLRKIVAAEGVGSLFKGCGANILRGVAGAGVISMYDQLQMILFGKKFK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSNAQVKT
------CCCCCCCCC		32.0922890988
3Phosphorylation-----MSSNAQVKTP
-----CCCCCCCCCC		34.5822890988
8UbiquitinationMSSNAQVKTPLPPAP
CCCCCCCCCCCCCCC		32.1417644757
9PhosphorylationSSNAQVKTPLPPAPA
CCCCCCCCCCCCCCC		31.0722890988
182-HydroxyisobutyrylationLPPAPAPKKESNFLI
CCCCCCCCCCCCCHH		71.87-
18UbiquitinationLPPAPAPKKESNFLI
CCCCCCCCCCCCCHH		71.8717644757
19UbiquitinationPPAPAPKKESNFLID
CCCCCCCCCCCCHHH		66.3717644757
21PhosphorylationAPAPKKESNFLIDFL
CCCCCCCCCCHHHHH		41.5819779198
38UbiquitinationGVSAAVAKTAASPIE
CHHHHHHHHCCCHHH		31.9017644757
39PhosphorylationVSAAVAKTAASPIER
HHHHHHHHCCCHHHH		20.0928889911
42PhosphorylationAVAKTAASPIERVKL
HHHHHCCCHHHHHHH		24.7721440633
48UbiquitinationASPIERVKLLIQNQD
CCHHHHHHHHHHCHH		43.7417644757
48AcetylationASPIERVKLLIQNQD
CCHHHHHHHHHHCHH		43.7424489116
59UbiquitinationQNQDEMLKQGTLDRK
HCHHHHHHHCCCCHH		45.4223749301
59AcetylationQNQDEMLKQGTLDRK
HCHHHHHHHCCCCHH		45.4224489116
66AcetylationKQGTLDRKYAGILDC
HHCCCCHHHHHHHHH		38.8425381059
66UbiquitinationKQGTLDRKYAGILDC
HHCCCCHHHHHHHHH		38.8417644757
75UbiquitinationAGILDCFKRTATQEG
HHHHHHHHHCCCCCC		55.9917644757
75AcetylationAGILDCFKRTATQEG
HHHHHHHHHCCCCCC		55.9924489116
77PhosphorylationILDCFKRTATQEGVI
HHHHHHHCCCCCCCE		34.3519779198
79PhosphorylationDCFKRTATQEGVISF
HHHHHCCCCCCCEEE		26.9230377154
108AcetylationQALNFAFKDKIKAMF
HHHHHHHHHHHHHHH		55.4725381059
108UbiquitinationQALNFAFKDKIKAMF
HHHHHHHHHHHHHHH		55.4717644757
110UbiquitinationLNFAFKDKIKAMFGF
HHHHHHHHHHHHHCC		46.8517644757
112UbiquitinationFAFKDKIKAMFGFKK
HHHHHHHHHHHCCCC		39.2717644757
1122-HydroxyisobutyrylationFAFKDKIKAMFGFKK
HHHHHHHHHHHCCCC		39.27-
118AcetylationIKAMFGFKKEEGYAK
HHHHHCCCCCCCCHH		60.7024489116
119AcetylationKAMFGFKKEEGYAKW
HHHHCCCCCCCCHHH		59.7524489116
1192-HydroxyisobutyrylationKAMFGFKKEEGYAKW
HHHHCCCCCCCCHHH		59.75-
1602-HydroxyisobutyrylationTRLAADSKSSKKGGA
HHHHHCCCCCCCCCC		60.33-
160AcetylationTRLAADSKSSKKGGA
HHHHHCCCCCCCCCC		60.3325381059
161PhosphorylationRLAADSKSSKKGGAR
HHHHCCCCCCCCCCH		51.8728889911
162PhosphorylationLAADSKSSKKGGARQ
HHHCCCCCCCCCCHH		41.9728889911
1822-HydroxyisobutyrylationDVYKKTLKSDGVAGL
HHHHHHHCCCCCHHH		52.30-
182SuccinylationDVYKKTLKSDGVAGL
HHHHHHHCCCCCHHH		52.3023954790
182AcetylationDVYKKTLKSDGVAGL
HHHHHHHCCCCCHHH		52.3024489116
259PhosphorylationRRRMMMTSGQAVKYD
HHHHHCCCCCCEECC		15.8327214570
264UbiquitinationMTSGQAVKYDGAFDC
CCCCCCEECCCHHHH		40.4117644757
264AcetylationMTSGQAVKYDGAFDC
CCCCCCEECCCHHHH		40.4124489116
274UbiquitinationGAFDCLRKIVAAEGV
CHHHHHHHHHHHHCC		28.6917644757
2742-HydroxyisobutyrylationGAFDCLRKIVAAEGV
CHHHHHHHHHHHHCC		28.69-
286UbiquitinationEGVGSLFKGCGANIL
HCCHHHHCCCCHHHH		59.5917644757
286AcetylationEGVGSLFKGCGANIL
HCCHHHHCCCCHHHH		59.59-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADT2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADT2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADT2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ADT3_YEASTAAC3genetic
15238515
CMC1_YEASTSAL1genetic
15238515
YME1_YEASTYME1genetic
18809618
DLD1_YEASTDLD1physical
18779372
NDH1_YEASTNDE1physical
18779372
QCR1_YEASTCOR1physical
18779372
HEMH_YEASTHEM15physical
18779372
QCR2_YEASTQCR2physical
18779372
FSF1_YEASTFSF1physical
18779372
CY1_YEASTCYT1physical
18779372
COX2_YEASTCOX2physical
18779372
GGC1_YEASTGGC1physical
18779372
MPCP_YEASTMIR1physical
18779372
ADT1_YEASTAAC1physical
18779372
DIC1_YEASTDIC1physical
18779372
VDAC1_YEASTPOR1physical
18779372
SCO2_YEASTSCO2physical
18779372
FMP10_YEASTFMP10physical
18779372
SDHB_YEASTSDH2physical
18779372
QCR7_YEASTQCR7physical
18779372
COX4_YEASTCOX4physical
18779372
COX5A_YEASTCOX5Aphysical
18779372
COX6_YEASTCOX6physical
18779372
COX13_YEASTCOX13physical
18779372
CYC1_YEASTCYC1physical
18779372
QCR10_YEASTQCR10physical
18779372
COX12_YEASTCOX12physical
18779372
UCRI_YEASTRIP1physical
18779372
MPCP_YEASTMIR1genetic
18779372
GGC1_YEASTGGC1genetic
18779372
CYB_YEASTCOBphysical
18779372
COX9_YEASTCOX9physical
18779372
MSS51_YEASTMSS51physical
18779372
ADH3_YEASTADH3physical
18779372
PIC2_YEASTPIC2physical
18779372
CRD1_YEASTCRD1genetic
18779372
COX2_YEASTCOX2physical
18614795
QCR1_YEASTCOR1physical
18614795
TIM17_YEASTTIM17physical
18614795
TIM23_YEASTTIM23physical
18614795
QCR2_YEASTQCR2physical
18614795
TIM50_YEASTTIM50physical
18614795
TIM44_YEASTTIM44physical
18614795
TIM16_YEASTPAM16physical
18614795
TIM23_YEASTTIM23physical
19348890
COX5A_YEASTCOX5Aphysical
19348890
QCR1_YEASTCOR1physical
19348890
QCR2_YEASTQCR2physical
19348890
SCH9_YEASTSCH9genetic
19160490
REI1_YEASTREI1genetic
19160490
RL6B_YEASTRPL6Bgenetic
19160490
TCTP_YEASTTMA19genetic
19160490
RPD3_YEASTRPD3genetic
19160490
RL31A_YEASTRPL31Agenetic
19160490
CY1_YEASTCYT1genetic
19160490
COX4_YEASTCOX4genetic
19160490
PHB1_YEASTPHB1genetic
19160490
PHB2_YEASTPHB2genetic
19160490
YME1_YEASTYME1genetic
19160490
SEC22_YEASTSEC22physical
16093310
COX6_YEASTCOX6genetic
21623372
CYS3_YEASTCYS3genetic
21623372
INO1_YEASTINO1genetic
21623372
CRD1_YEASTCRD1genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
ASNS2_YEASTASN2genetic
21623372
ALDH6_YEASTALD6genetic
21623372
TAZ1_YEASTTAZ1genetic
21623372
GPP2_YEASTGPP2genetic
21623372
DPH5_YEASTDPH5genetic
21623372
PHSG_YEASTGPH1genetic
21623372
HMDH2_YEASTHMG2genetic
21623372
GPD1_YEASTGPD1genetic
21623372
ADE_YEASTAAH1genetic
21623372
KCS1_YEASTKCS1genetic
21623372
ASNS1_YEASTASN1genetic
21623372
ODP2_YEASTLAT1genetic
21623372
ADH2_YEASTADH2genetic
21623372
ACS1_YEASTACS1genetic
21623372
THRC_YEASTTHR4genetic
21623372
ARO1_YEASTARO1genetic
21623372
SOL3_YEASTSOL3genetic
21623372
IPK1_YEASTIPK1genetic
21623372
ERG6_YEASTERG6genetic
21623372
GCSH_YEASTGCV3genetic
21623372
ATPK_YEASTATP17genetic
21623372
ATH1_YEASTATH1genetic
21623372
APA2_YEASTAPA2genetic
21623372
NDH2_YEASTNDE2genetic
21623372
ODPB_YEASTPDB1genetic
21623372
THI7_YEASTTHI7genetic
21623372
GSHR_YEASTGLR1genetic
21623372
FMS1_YEASTFMS1genetic
21623372
IAH1_YEASTIAH1genetic
21623372
PPT2_YEASTPPT2genetic
21623372
GLRX1_YEASTGRX1genetic
21623372
MAOM_YEASTMAE1genetic
21623372
PYRD_YEASTURA1genetic
21623372
ATPF_YEASTATP4physical
22310663
QCR1_YEASTCOR1physical
22310663
COX2_YEASTCOX2physical
22310663
COX4_YEASTCOX4physical
22310663
RCF1_YEASTRCF1physical
22310663
PMP1_YEASTPMP1physical
26404137
YME1_YEASTYME1genetic
25833713
OXA1_YEASTOXA1genetic
25833713
PSD1_YEASTPSD1genetic
25833713
DOT6_YEASTDOT6genetic
26192197
FHL1_YEASTFHL1genetic
26192197
RPD3_YEASTRPD3genetic
26192197
TOD6_YEASTTOD6genetic
26192197
IF4E_YEASTCDC33genetic
26192197
DCP2_YEASTDCP2genetic
26192197
EDC3_YEASTEDC3genetic
26192197
NAM7_YEASTNAM7genetic
26192197
PBP1_YEASTPBP1genetic
26192197
EIF3B_YEASTPRT1genetic
26192197
PSP2_YEASTPSP2genetic
26192197
IF4B_YEASTTIF3genetic
26192197
IF4F2_YEASTTIF4632genetic
26192197
REB1_YEASTREB1genetic
26192197
RL38_YEASTRPL38genetic
26192197
RL40A_YEASTRPL40Bgenetic
26192197
RL40B_YEASTRPL40Bgenetic
26192197
RLA0_YEASTRPP0genetic
26192197
RS6A_YEASTRPS6Bgenetic
26192197
RS6B_YEASTRPS6Bgenetic
26192197
TRMB_YEASTTRM8genetic
26192197
TRM11_YEASTTRM11genetic
26192197
MMS2_YEASTMMS2genetic
26192197
POC4_YEASTPOC4genetic
26192197
SAF1_YEASTSAF1genetic
26192197
SSB1_YEASTSSB1genetic
26192197
SSB2_YEASTSSB2genetic
26192197
UBP3_YEASTUBP3genetic
26192197
UMP1_YEASTUMP1genetic
26192197
ZUO1_YEASTZUO1genetic
26192197
HRR25_YEASTHRR25genetic
26192197
KIN2_YEASTKIN2genetic
26192197
RGI1_YEASTRGI1genetic
26192197
SSY5_YEASTSSY5genetic
26192197
YEG7_YEASTYEL057Cgenetic
26192197
YMW4_YEASTYMR074Cgenetic
26192197
YO098_YEASTYOL098Cgenetic
26192197
YP022_YEASTYPR022Cgenetic
26192197
GIS2_YEASTGIS2genetic
26192197
NOG2_YEASTNOG2genetic
26192197
TMA7_YEASTTMA7genetic
26192197
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADT2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-39 AND SER-42, AND MASSSPECTROMETRY.

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