ATH1_YEAST - dbPTM
ATH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ATH1_YEAST
UniProt AC P48016
Protein Name Vacuolar acid trehalase
Gene Name ATH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1211
Subcellular Localization Vacuole. Lysosome-like vacuoles.
Protein Description
Protein Sequence MKRIRSLWFNAEASYSNLNNSPSLRNKNSTGNNSRSKNYRSFSRFDLINSILLLMMLFLLAIFVTALYLTKSSRLTYSHASRAALFNPLGVISPSLGNHTLNYDPEARESSKKLYELLSDFNTAYYDDENMILGSNLFSKNTYSRQPYVANGYIGSRIPNIGFGYALDTLNFYTDAPGALNNGWPLRNHRFAGAFVSDFYCLQPKLNSTNFPELDDVGYSTVISSIPQWTNLQFSLVNDSKWFNPQNVTLDDVTNYSQNLSMKDGIVTTELDWLNSQIHVKSEIWAHRHIHPLGVVSLEISLNTDHLPSDFDSLDVNIWDILDFNTSHRTVLHSTGTDEKNNAVFMIVQPDNVPSSNCAIYSTCTVKYENSTNPINSSESFEEKDVSSNIYNVILTEDQPKIIVHKYVGIMSTEFNKNKEQQDNTNIGLAKMIALNSKGNYEKLLSSHKRAWYDLYNDAFIEIPSDSLLEMTARSSLFHLLANTRDYNVSSDRGLPVGVSGLSSDSYGGMVFWDADIWMEPALLPFFPNVAQNMNNYRNATHSQAKLNAEKYGYPGAIYPWTSGKYANCTSTGPCVDYEYHINVDVAMASFSIYLNGHEGIDDEYLRYTTWPIIKNAAQFFTAYVKYNSSLGLYETYNLTDPDEFANHINNGAFTNAGIKTLLKWATDIGNHLGEVVDPKWSEISKDIYIPRSSSNITLEYSGMNSSVEIKQADVTLMVYPLGYINDESILNNAIKDLYYYSERQSASGPAMTYPVFVAAAAGLLNHGSSSQSYLYKSVLPYLRAPFAQFSEQSDDNFLTNGLTQPAFPFLTANGGFLQSILFGLTGIRYSYEVDPDTKKINRLLRFNPIELPLLPGGIAIRNFKYMNQVLDIIIDDHNGTIVHKSGDVPIHIKIPNRSLIHDQDINFYNGSENERKPNLERRDVDRVGDPMRMDRYGTYYLLKPKQELTVQLFKPGLNARNNIAENKQITNLTAGVPGDVAFSALDGNNYTHWQPLDKIHRAKLLIDLGEYNEKEITKGMILWGQRPAKNISISILPHSEKVENLFANVTEIMQNSGNDQLLNETIGQLLDNAGIPVENVIDFDGIEQEDDESLDDVQALLHWKKEDLAKLIEQIPRLNFLKRKFVKILDNVPVSPSEPYYEASRNQSLIEILPSNRTTFTIDYDKLQVGDKGNTDWRKTRYIVVAVQGVYDDYDDDNKGATIKEIVLND
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationPSLRNKNSTGNNSRS
HHHCCCCCCCCCCCC		39.0224930733
34PhosphorylationKNSTGNNSRSKNYRS
CCCCCCCCCCCCCCC		41.7624930733
98N-linked_GlycosylationVISPSLGNHTLNYDP
EECCCCCCCCCCCCH		30.20-
207N-linked_GlycosylationYCLQPKLNSTNFPEL
EECCCCCCCCCCCCH		53.57-
238N-linked_GlycosylationNLQFSLVNDSKWFNP
CEEEEECCCCCCCCC		53.80-
247N-linked_GlycosylationSKWFNPQNVTLDDVT
CCCCCCCCCCHHHHH		29.96-
255N-linked_GlycosylationVTLDDVTNYSQNLSM
CCHHHHHCCCCCCCC		34.02-
259N-linked_GlycosylationDVTNYSQNLSMKDGI
HHHCCCCCCCCCCCE		28.30-
325N-linked_GlycosylationIWDILDFNTSHRTVL
HHHHHCCCCCCCEEE		40.10-
370N-linked_GlycosylationTCTVKYENSTNPINS
EEEEEECCCCCCCCC		51.55-
376N-linked_GlycosylationENSTNPINSSESFEE
CCCCCCCCCCHHHCC		40.51-
476PhosphorylationLEMTARSSLFHLLAN
HHHHHHHHHHHHHHH		29.5119779198
487PhosphorylationLLANTRDYNVSSDRG
HHHHCCCCCCCCCCC		17.7419779198
488N-linked_GlycosylationLANTRDYNVSSDRGL
HHHCCCCCCCCCCCC		31.33-
490PhosphorylationNTRDYNVSSDRGLPV
HCCCCCCCCCCCCCC		23.9219779198
539N-linked_GlycosylationQNMNNYRNATHSQAK
HHHHHHCCCCHHHHH		38.54-
568N-linked_GlycosylationWTSGKYANCTSTGPC
CCCCCCCCCCCCCCE		26.89-
628N-linked_GlycosylationFTAYVKYNSSLGLYE
HHHHHCCCCCCCCEE		21.29-
638N-linked_GlycosylationLGLYETYNLTDPDEF
CCCEEEECCCCHHHH		43.83-
696N-linked_GlycosylationYIPRSSSNITLEYSG
ECCCCCCCEEEEECC		32.96-
705N-linked_GlycosylationTLEYSGMNSSVEIKQ
EEEECCCCCCEEEEE		34.36-
754PhosphorylationASGPAMTYPVFVAAA
CCCCCCHHHHHHHHH		5.5928132839
773PhosphorylationNHGSSSQSYLYKSVL
HCCCCCHHHHHHHHH		21.0328889911
879N-linked_GlycosylationDIIIDDHNGTIVHKS
EEEEECCCCEEEECC		57.19-
897N-linked_GlycosylationPIHIKIPNRSLIHDQ
CEEEECCCCCCCCCC		50.04-
910N-linked_GlycosylationDQDINFYNGSENERK
CCCCCCCCCCCCCCC		43.29-
972N-linked_GlycosylationAENKQITNLTAGVPG
CCCCCCCCCCCCCCC		36.70-
990N-linked_GlycosylationFSALDGNNYTHWQPL
EECCCCCCCCCCEEC		48.92-
1031N-linked_GlycosylationWGQRPAKNISISILP
ECCCCCCCEEEEECC		35.03-
1049N-linked_GlycosylationKVENLFANVTEIMQN
HHHHHHHHHHHHHHH		33.63-
1064N-linked_GlycosylationSGNDQLLNETIGQLL
CCCHHHHHHHHHHHH		53.62-
1147N-linked_GlycosylationPYYEASRNQSLIEIL
CCCCCCCCCCCEEEC		33.04-
1157N-linked_GlycosylationLIEILPSNRTTFTID
CEEECCCCCCEEEEE		43.29-
1192PhosphorylationVVAVQGVYDDYDDDN
EEEEEEEECCCCCCC		15.2128889911
1195PhosphorylationVQGVYDDYDDDNKGA
EEEEECCCCCCCCCC		20.5528889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ATH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ATH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ATH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SSB1_YEASTSSB1physical
19536198
TREA_YEASTNTH1genetic
19180643
TREB_YEASTNTH2genetic
19180643
TPS1_YEASTTPS1genetic
20159575
TPS2_YEASTTPS2genetic
20159575
TPS1_YEASTTPS1genetic
19180643
TPS2_YEASTTPS2genetic
19180643
ADK_YEASTADO1genetic
21623372
THDH_YEASTILV1genetic
21623372
METC_YEASTIRC7genetic
21623372
ARGJ_YEASTARG7genetic
21623372
PDX3_YEASTPDX3genetic
21623372
MAL11_YEASTMAL11genetic
25918382
RPB1_YEASTRPO21genetic
27708008
RSP5_YEASTRSP5genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
GFA1_YEASTGFA1genetic
27708008
HRR25_YEASTHRR25genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ATH1_YEAST

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Related Literatures of Post-Translational Modification

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