ADK_YEAST - dbPTM
ADK_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADK_YEAST
UniProt AC P47143
Protein Name Adenosine kinase
Gene Name ADO1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 340
Subcellular Localization
Protein Description ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. ADO1 does not play a major role in adenine utilization in yeast. Its physiological role could primarily be to recycle adenosine produced by the methyl cycle..
Protein Sequence MTAPLVVLGNPLLDFQADVTAEYLAKYSLKENDAILVDAKSGDAKMAIFDELLQMPETKLVAGGAAQNTARGAAYVLGAGQVVYFGSVGKDKFSERLLNENEKAGVKSMYQVQNDIGTGKCAALITGHNRSLVTDLGAANFFTPDHLDKHWDLVEAAKLFYIGGFHLTVSPDAIVKLGQHAKENSKPFVLNFSAPFIPHVFKDALARVLPYATVIIANESEAEAFCDAFQLDCANTDLEAIAQRIVKDSPVEKTVIFTHGVEPTVVVSSKGTSTYPVKPLDSSKIVDTNGAGDAFAGGFMAGLTKGEDLETSIDMGQWLAALSIQEVGPSYPSEKISYSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26UbiquitinationVTAEYLAKYSLKEND
HCHHHHHHCCCCCCC		32.5522817900
30AcetylationYLAKYSLKENDAILV
HHHHCCCCCCCEEEE		48.8324489116
30UbiquitinationYLAKYSLKENDAILV
HHHHCCCCCCCEEEE		48.8323749301
40UbiquitinationDAILVDAKSGDAKMA
CEEEEECCCCCHHHH		50.9723749301
40SuccinylationDAILVDAKSGDAKMA
CEEEEECCCCCHHHH		50.9723954790
40AcetylationDAILVDAKSGDAKMA
CEEEEECCCCCHHHH		50.9724489116
402-HydroxyisobutyrylationDAILVDAKSGDAKMA
CEEEEECCCCCHHHH		50.97-
45UbiquitinationDAKSGDAKMAIFDEL
ECCCCCHHHHHHHHH		33.3423749301
69PhosphorylationAGGAAQNTARGAAYV
CCCHHHHHHHHHEEE		12.9722369663
103AcetylationRLLNENEKAGVKSMY
HHCCCCCCCCCCHHE		63.1224489116
103SuccinylationRLLNENEKAGVKSMY
HHCCCCCCCCCCHHE		63.1223954790
107UbiquitinationENEKAGVKSMYQVQN
CCCCCCCCHHEEEEC		28.7023749301
107SuccinylationENEKAGVKSMYQVQN
CCCCCCCCHHEEEEC		28.7023954790
108PhosphorylationNEKAGVKSMYQVQND
CCCCCCCHHEEEECC		21.9521440633
120UbiquitinationQNDIGTGKCAALITG
ECCCCCCCEEEEECC		22.1223749301
149AcetylationFTPDHLDKHWDLVEA
CCHHHHHHCCHHHHH		53.6124489116
202AcetylationPFIPHVFKDALARVL
CCHHHHHHHHHHHHH		40.7924489116
247SuccinylationAIAQRIVKDSPVEKT
HHHHHHHCCCCCCEE		50.5523954790
247AcetylationAIAQRIVKDSPVEKT
HHHHHHHCCCCCCEE		50.5522865919
247UbiquitinationAIAQRIVKDSPVEKT
HHHHHHHCCCCCCEE		50.5523749301
249PhosphorylationAQRIVKDSPVEKTVI
HHHHHCCCCCCEEEE		25.7323749301
268PhosphorylationVEPTVVVSSKGTSTY
CCCEEEEECCCCCCE		18.0919823750
269PhosphorylationEPTVVVSSKGTSTYP
CCEEEEECCCCCCEE		24.4021440633
270UbiquitinationPTVVVSSKGTSTYPV
CEEEEECCCCCCEEC		59.7223749301
273PhosphorylationVVSSKGTSTYPVKPL
EEECCCCCCEECCCC		34.3121440633
274PhosphorylationVSSKGTSTYPVKPLD
EECCCCCCEECCCCC		31.5122369663
275PhosphorylationSSKGTSTYPVKPLDS
ECCCCCCEECCCCCC		13.0422369663
278AcetylationGTSTYPVKPLDSSKI
CCCCEECCCCCCCCE		35.0524489116
278UbiquitinationGTSTYPVKPLDSSKI
CCCCEECCCCCCCCE		35.0523749301
282PhosphorylationYPVKPLDSSKIVDTN
EECCCCCCCCEECCC		41.0122369663
283PhosphorylationPVKPLDSSKIVDTNG
ECCCCCCCCEECCCC		26.5221440633
288PhosphorylationDSSKIVDTNGAGDAF
CCCCEECCCCCCCCC		25.3419823750
304PhosphorylationGGFMAGLTKGEDLET
CCCCCCCCCCCCCHH		35.7619823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADK_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADK_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADK_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATG14_YEASTATG14genetic
19269370
OCA6_YEASTOCA6genetic
19269370
VHS1_YEASTVHS1genetic
19269370
SLX9_YEASTSLX9genetic
19269370
PIL1_YEASTPIL1genetic
19269370
OCA5_YEASTOCA5genetic
19269370
PRR1_YEASTPRR1genetic
19269370
DS1P2_YEASTYSR3genetic
19269370
ATG17_YEASTATG17genetic
19269370
SIW14_YEASTSIW14genetic
19269370
OCA2_YEASTOCA2genetic
19269370
RAS2_YEASTRAS2genetic
19269370
OCA1_YEASTOCA1genetic
19269370
INP52_YEASTINP52genetic
19269370
YP150_YEASTYPL150Wgenetic
19269370
PPQ1_YEASTPPQ1genetic
19269370
PLC1_YEASTPLC1genetic
19269370
SSB1_YEASTSSB1physical
19536198
UBP8_YEASTUBP8genetic
21288874
VPS72_YEASTVPS72genetic
21288874
MET22_YEASTMET22genetic
21623372
TGL2_YEASTTGL2genetic
21623372
PUR1_YEASTADE4genetic
25769345
CDC24_YEASTCDC24genetic
27708008
CDS1_YEASTCDS1genetic
27708008
DPOD_YEASTPOL3genetic
27708008
DAD1_YEASTDAD1genetic
27708008
RRP1_YEASTRRP1genetic
27708008
TAF12_YEASTTAF12genetic
27708008
TRS23_YEASTTRS23genetic
27708008
GPI19_YEASTGPI19genetic
27708008
KGUA_YEASTGUK1genetic
27708008
MOB1_YEASTMOB1genetic
27708008
TAF11_YEASTTAF11genetic
27708008
POB3_YEASTPOB3genetic
27708008
SEC65_YEASTSEC65genetic
27708008
NOG2_YEASTNOG2genetic
27708008
GPI2_YEASTGPI2genetic
27708008
NIP7_YEASTNIP7genetic
27708008
BUR1_YEASTSGV1genetic
27708008
DPM1_YEASTDPM1genetic
27708008
DEP1_YEASTDEP1genetic
27708008
RXT2_YEASTRXT2genetic
27708008
SWC5_YEASTSWC5genetic
27708008
MGR1_YEASTMGR1genetic
27708008
RPN4_YEASTRPN4genetic
27708008
VAM6_YEASTVAM6genetic
27708008
MAF1_YEASTMAF1genetic
27708008
TGL2_YEASTTGL2genetic
27708008
INO2_YEASTINO2genetic
27708008
DHAS_YEASTHOM2genetic
27708008
SND1_YEASTYDR186Cgenetic
27708008
SNF1_YEASTSNF1genetic
27708008
VPS72_YEASTVPS72genetic
27708008
AK_YEASTHOM3genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
AAKG_YEASTSNF4genetic
27708008
BUB1_YEASTBUB1genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
SDS3_YEASTSDS3genetic
27708008
ICE2_YEASTICE2genetic
27708008
VPS24_YEASTVPS24genetic
27708008
MIC60_YEASTMIC60genetic
27708008
RIC1_YEASTRIC1genetic
27708008
ERG3_YEASTERG3genetic
27708008
ARP6_YEASTARP6genetic
27708008
MMR1_YEASTMMR1genetic
27708008
UPS1_YEASTUPS1genetic
27708008
YPT6_YEASTYPT6genetic
27708008
CST9_YEASTCST9genetic
27708008
VPS71_YEASTVPS71genetic
27708008
SIW14_YEASTSIW14genetic
27708008
TPM1_YEASTTPM1genetic
27708008
VPS27_YEASTVPS27genetic
27708008
SIN3_YEASTSIN3genetic
27708008
CSK22_YEASTCKA2genetic
27708008
GYP1_YEASTGYP1genetic
27708008
SERC_YEASTSER1genetic
27708008
ARL3_YEASTARL3genetic
27708008
YME1_YEASTYME1genetic
27708008
VIP1_YEASTVIP1genetic
28520786
THP3_YEASTTHP3genetic
28520786
CTK2_YEASTCTK2genetic
28520786
GSH1_YEASTGSH1genetic
28520786
RSA1_YEASTRSA1genetic
28520786
DOA10_YEASTSSM4genetic
28520786
PHO81_YEASTPHO81genetic
28520786
PHO4_YEASTPHO4genetic
28520786
ATG11_YEASTATG11genetic
28520786
MMS2_YEASTMMS2genetic
28520786
ADA2_YEASTADA2genetic
28520786
TMA23_YEASTTMA23genetic
28520786
MAG2_YEASTMAG2genetic
28520786
MIT1_YEASTMIT1genetic
28520786
DPH3_YEASTKTI11genetic
28520786
YMK8_YEASTYML108Wgenetic
28520786
PALF_YEASTRIM8genetic
28520786
PDR16_YEASTPDR16genetic
28520786
VDAC2_YEASTPOR2genetic
28520786
TKT1_YEASTTKL1genetic
28520786
RL36B_YEASTRPL36Bgenetic
28520786
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADK_YEAST

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Related Literatures of Post-Translational Modification

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