| UniProt ID | MIC60_YEAST | |
|---|---|---|
| UniProt AC | P36112 | |
| Protein Name | MICOS complex subunit MIC60 | |
| Gene Name | MIC60 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 540 | |
| Subcellular Localization |
Mitochondrion inner membrane Single-pass membrane protein . Enriched at crista junctions. |
|
| Protein Description | Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.. | |
| Protein Sequence | MMLRTTASRKIVLRRGLASINTGTTVASKKASHKFRNTLWTIALSATAFYAGGIIYSQKNDKFGDFFSNNVPFAEDLLETYEHYHDRPTLFLEDSWDGLKAKSNDLLSGLTGSSQTRRSNRENIEVKKILSLEPLNIETENSDPQLKEIIGSLNDLINSLNDSNLSIPESEFNSIKKSNQNMLTNLSQLNETLKEALSNYMIQRTSEVITELNTQYENSKREFEKNLQKNLLQEVDEFKENLTKQKDKELEEKLKANEELLQAKHANEVGLLSITQVKEFNKIIKDKIEKERNGRLAHLEEINSEVNDLSKSIDRSSKILSKNEALVQLTFQVDEIKSRINNNNLPDVNIDKELSRLKLLSNLLSTFNKKSCCDDGDCCSCKKGNKNEGKEGKISCKCKPKTNPPSLLSVALDELESTCSGKKILSNEQIYNRWNLLADDFKTASLLPPNSGILGQLTAKVFSLFLFTKTGNPSNATDFDSVYARVGDNLRVSNLNDAVEEVVSLKGWPHKVCESWIEDARRKLEVQRLVEILDCEIRTL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MMLRTTASRKIV ---CCCCCHHHCHHH | 23749301 | ||
| 6 | Phosphorylation | --MMLRTTASRKIVL --CCCCCHHHCHHHH | 23749301 | ||
| 102 | Acetylation | SWDGLKAKSNDLLSG CCCHHHHHHCCHHHC | 24489116 | ||
| 304 | Phosphorylation | AHLEEINSEVNDLSK CCHHHHHHHHHHHHH | 28889911 | ||
| 310 | Phosphorylation | NSEVNDLSKSIDRSS HHHHHHHHHHCHHHH | 28889911 | ||
| 311 | Acetylation | SEVNDLSKSIDRSSK HHHHHHHHHCHHHHH | 24489116 | ||
| 352 | Acetylation | LPDVNIDKELSRLKL CCCCCCCHHHHHHHH | 24489116 | ||
| 358 | Acetylation | DKELSRLKLLSNLLS CHHHHHHHHHHHHHH | 24489116 | ||
| 369 | Acetylation | NLLSTFNKKSCCDDG HHHHHCCCCCCCCCC | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MIC60_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIC60_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIC60_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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