| UniProt ID | ILV3_YEAST | |
|---|---|---|
| UniProt AC | P39522 | |
| Protein Name | Dihydroxy-acid dehydratase, mitochondrial | |
| Gene Name | ILV3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 585 | |
| Subcellular Localization | Mitochondrion. | |
| Protein Description | ||
| Protein Sequence | MGLLTKVATSRQFSTTRCVAKKLNKYSYIITEPKGQGASQAMLYATGFKKEDFKKPQVGVGSCWWSGNPCNMHLLDLNNRCSQSIEKAGLKAMQFNTIGVSDGISMGTKGMRYSLQSREIIADSFETIMMAQHYDANIAIPSCDKNMPGVMMAMGRHNRPSIMVYGGTILPGHPTCGSSKISKNIDIVSAFQSYGEYISKQFTEEEREDVVEHACPGPGSCGGMYTANTMASAAEVLGLTIPNSSSFPAVSKEKLAECDNIGEYIKKTMELGILPRDILTKEAFENAITYVVATGGSTNAVLHLVAVAHSAGVKLSPDDFQRISDTTPLIGDFKPSGKYVMADLINVGGTQSVIKYLYENNMLHGNTMTVTGDTLAERAKKAPSLPEGQEIIKPLSHPIKANGHLQILYGSLAPGGAVGKITGKEGTYFKGRARVFEEEGAFIEALERGEIKKGEKTVVVIRYEGPRGAPGMPEMLKPSSALMGYGLGKDVALLTDGRFSGGSHGFLIGHIVPEAAEGGPIGLVRDGDEIIIDADNNKIDLLVSDKEMAQRKQSWVAPPPRYTRGTLSKYAKLVSNASNGCVLDA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 22 | Acetylation | TTRCVAKKLNKYSYI CHHHHHHHHCCCEEE | 47.78 | 24489116 | |
| 25 | Acetylation | CVAKKLNKYSYIITE HHHHHHCCCEEEEEC | 46.11 | 24489116 | |
| 26 | Phosphorylation | VAKKLNKYSYIITEP HHHHHCCCEEEEECC | 12.96 | 28889911 | |
| 34 | Acetylation | SYIITEPKGQGASQA EEEEECCCCCCHHHH | 58.60 | 24489116 | |
| 49 | Acetylation | MLYATGFKKEDFKKP HHHHCCCCHHHCCCC | 57.51 | 24489116 | |
| 49 | Succinylation | MLYATGFKKEDFKKP HHHHCCCCHHHCCCC | 57.51 | 23954790 | |
| 54 | Acetylation | GFKKEDFKKPQVGVG CCCHHHCCCCCEEEE | 75.71 | 25381059 | |
| 87 | Acetylation | RCSQSIEKAGLKAMQ HHHHHHHHHCCCEEE | 46.19 | 25381059 | |
| 97 | Phosphorylation | LKAMQFNTIGVSDGI CCEEECCEECEECCC | 22.01 | 22369663 | |
| 101 | Phosphorylation | QFNTIGVSDGISMGT ECCEECEECCCCCCC | 25.55 | 22369663 | |
| 105 | Phosphorylation | IGVSDGISMGTKGMR ECEECCCCCCCCCCC | 19.38 | 22369663 | |
| 108 | Phosphorylation | SDGISMGTKGMRYSL ECCCCCCCCCCCCCC | 18.78 | 22369663 | |
| 109 | Acetylation | DGISMGTKGMRYSLQ CCCCCCCCCCCCCCH | 45.00 | 24489116 | |
| 183 | Acetylation | CGSSKISKNIDIVSA CCCCHHHCCCCHHHH | 62.49 | 24489116 | |
| 254 | Acetylation | FPAVSKEKLAECDNI CCCCCHHHHHCCCCH | 57.65 | 25381059 | |
| 266 | Acetylation | DNIGEYIKKTMELGI CCHHHHHHHHHHCCC | 41.09 | 24489116 | |
| 324 | Phosphorylation | PDDFQRISDTTPLIG HHHHHHHCCCCCCCC | 30.97 | 28889911 | |
| 326 | Phosphorylation | DFQRISDTTPLIGDF HHHHHCCCCCCCCCC | 24.42 | 22369663 | |
| 327 | Phosphorylation | FQRISDTTPLIGDFK HHHHCCCCCCCCCCC | 22.53 | 22369663 | |
| 334 | Acetylation | TPLIGDFKPSGKYVM CCCCCCCCCCCCEEE | 42.91 | 24489116 | |
| 336 | Phosphorylation | LIGDFKPSGKYVMAD CCCCCCCCCCEEEEE | 48.81 | 22369663 | |
| 338 | Acetylation | GDFKPSGKYVMADLI CCCCCCCCEEEEEEE | 38.72 | 24489116 | |
| 350 | Phosphorylation | DLINVGGTQSVIKYL EEEECCCHHHHHHHH | 16.25 | 25533186 | |
| 352 | Phosphorylation | INVGGTQSVIKYLYE EECCCHHHHHHHHHH | 26.16 | 25533186 | |
| 356 | Phosphorylation | GTQSVIKYLYENNML CHHHHHHHHHHCCCC | 11.91 | 28152593 | |
| 367 | Phosphorylation | NNMLHGNTMTVTGDT CCCCCCCEEEECCHH | 20.86 | 28152593 | |
| 369 | Phosphorylation | MLHGNTMTVTGDTLA CCCCCEEEECCHHHH | 16.93 | 28152593 | |
| 371 | Phosphorylation | HGNTMTVTGDTLAER CCCEEEECCHHHHHH | 21.85 | 28152593 | |
| 374 | Phosphorylation | TMTVTGDTLAERAKK EEEECCHHHHHHHHH | 29.25 | 28152593 | |
| 384 | Phosphorylation | ERAKKAPSLPEGQEI HHHHHCCCCCCCCHH | 62.51 | 21440633 | |
| 393 | Acetylation | PEGQEIIKPLSHPIK CCCCHHEECCCCCCE | 45.63 | 24489116 | |
| 396 | Phosphorylation | QEIIKPLSHPIKANG CHHEECCCCCCEECC | 35.43 | 21440633 | |
| 424 | Acetylation | AVGKITGKEGTYFKG CEEEEECCCCCEEEC | 44.30 | 24489116 | |
| 424 | Succinylation | AVGKITGKEGTYFKG CEEEEECCCCCEEEC | 44.30 | 23954790 | |
| 424 | 2-Hydroxyisobutyrylation | AVGKITGKEGTYFKG CEEEEECCCCCEEEC | 44.30 | - | |
| 430 | Acetylation | GKEGTYFKGRARVFE CCCCCEEECCEEEEE | 36.75 | 24489116 | |
| 456 | Acetylation | GEIKKGEKTVVVIRY CCCCCCCEEEEEEEE | 56.11 | 25381059 | |
| 477 | Acetylation | PGMPEMLKPSSALMG CCCHHHHCCHHHHHH | 41.36 | 24489116 | |
| 479 | Phosphorylation | MPEMLKPSSALMGYG CHHHHCCHHHHHHCC | 27.02 | 22369663 | |
| 480 | Phosphorylation | PEMLKPSSALMGYGL HHHHCCHHHHHHCCC | 33.67 | 22369663 | |
| 485 | Phosphorylation | PSSALMGYGLGKDVA CHHHHHHCCCCCCEE | 8.66 | 22369663 | |
| 489 | Acetylation | LMGYGLGKDVALLTD HHHCCCCCCEEEEEC | 54.81 | 24489116 | |
| 544 | Phosphorylation | NKIDLLVSDKEMAQR CEEEEEECCHHHHHH | 42.82 | 22369663 | |
| 546 | Acetylation | IDLLVSDKEMAQRKQ EEEEECCHHHHHHHH | 41.71 | 24489116 | |
| 546 | Ubiquitination | IDLLVSDKEMAQRKQ EEEEECCHHHHHHHH | 41.71 | 24961812 | |
| 554 | Phosphorylation | EMAQRKQSWVAPPPR HHHHHHHCCCCCCCC | 26.93 | 22369663 | |
| 569 | Acetylation | YTRGTLSKYAKLVSN CCCCHHHHHHHHHHH | 52.95 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ILV3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ILV3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ILV3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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