ILV6_YEAST - dbPTM
ILV6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ILV6_YEAST
UniProt AC P25605
Protein Name Acetolactate synthase small subunit, mitochondrial
Gene Name ILV6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 309
Subcellular Localization Mitochondrion.
Protein Description Stimulates activity of the acetolactate synthase catalytic subunit ILV2 seven- to tenfold and confers sensitivity to inhibition by valine and activation by ATP..
Protein Sequence MLRSLLQSGHRRVVASSCATMVRCSSSSTSALAYKQMHRHATRPPLPTLDTPSWNANSAVSSIIYETPAPSRQPRKQHVLNCLVQNEPGVLSRVSGTLAARGFNIDSLVVCNTEVKDLSRMTIVLQGQDGVVEQARRQIEDLVPVYAVLDYTNSEIIKRELVMARISLLGTEYFEDLLLHHHTSTNAGAADSQELVAEIREKQFHPANLPASEVLRLKHEHLNDITNLTNNFGGRVVDISETSCIVELSAKPTRISAFLKLVEPFGVLECARSGMMALPRTPLKTSTEEAADEDEKISEIVDISQLPPG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationGHRRVVASSCATMVR
CCHHHHHHHHCEEEE		17.8428889911
17PhosphorylationHRRVVASSCATMVRC
CHHHHHHHHCEEEEC		9.6830377154
26PhosphorylationATMVRCSSSSTSALA
CEEEECCCCCHHHHH		31.7521440633
51PhosphorylationPPLPTLDTPSWNANS
CCCCCCCCCCCCCCC		23.4930377154
61PhosphorylationWNANSAVSSIIYETP
CCCCCCHHHHHHCCC		18.6130377154
116AcetylationVVCNTEVKDLSRMTI
EEECCCCCCHHHCEE		46.8724489116
158AcetylationYTNSEIIKRELVMAR
CCCCHHHHHHHHHHH		45.5425381059
202UbiquitinationLVAEIREKQFHPANL
HHHHHHHHHCCCCCC		48.7124961812
202AcetylationLVAEIREKQFHPANL
HHHHHHHHHCCCCCC		48.7124489116
218AcetylationASEVLRLKHEHLNDI
HHHHHHHHHHHHHHH		40.2824489116
251AcetylationCIVELSAKPTRISAF
EEEEECCCCCCHHHH		43.4724489116
256PhosphorylationSAKPTRISAFLKLVE
CCCCCCHHHHHHHHC		15.0727017623
273PhosphorylationGVLECARSGMMALPR
CHHHHHHCCCCCCCC		16.7121440633
281PhosphorylationGMMALPRTPLKTSTE
CCCCCCCCCCCCCCH		30.9120377248
284UbiquitinationALPRTPLKTSTEEAA
CCCCCCCCCCCHHHC		41.4523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ILV6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ILV6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ILV6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ILVB_YEASTILV2physical
10213630
MFB1_YEASTMFB1genetic
20093466
AK_YEASTHOM3genetic
20093466
SGF73_YEASTSGF73genetic
20093466
YG036_YEASTYGL036Wgenetic
20093466
PHB2_YEASTPHB2genetic
20093466
FLX1_YEASTFLX1genetic
20093466
SDHX_YEASTYJL045Wgenetic
20093466
SAC1_YEASTSAC1genetic
20093466
HAP4_YEASTHAP4genetic
20093466
RL22A_YEASTRPL22Agenetic
20093466
ALAM_YEASTALT1genetic
20093466
COQ11_YEASTYLR290Cgenetic
20093466
ATG39_YEASTYLR312Cgenetic
20093466
MMS22_YEASTMMS22genetic
20093466
VRP1_YEASTVRP1genetic
20093466
SAM37_YEASTSAM37genetic
20093466
YO036_YEASTYOL036Wgenetic
20093466
ATG13_YEASTATG13genetic
20093466
FABD_YEASTMCT1genetic
21623372
METX_YEASTYML082Wgenetic
21623372
CBS_YEASTCYS4genetic
21623372
6PGD1_YEASTGND1genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
MRM2_YEASTMRM2genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
HSP7F_YEASTSSE1genetic
27708008
TECR_YEASTTSC13genetic
27708008
TEL2_YEASTTEL2genetic
27708008
NUF2_YEASTNUF2genetic
27708008
DIM1_YEASTDIM1genetic
27708008
ATG8_YEASTATG8genetic
27708008
PHB2_YEASTPHB2genetic
27708008
MED20_YEASTSRB2genetic
27708008
VPS24_YEASTVPS24genetic
27708008
SIC1_YEASTSIC1genetic
27708008
UPS2_YEASTUPS2genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
CDC73_YEASTCDC73genetic
27708008
STB4_YEASTSTB4genetic
27708008
SAM37_YEASTSAM37genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ILV6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16, AND MASSSPECTROMETRY.

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