| UniProt ID | HSP7F_YEAST | |
|---|---|---|
| UniProt AC | P32589 | |
| Protein Name | Heat shock protein homolog SSE1 | |
| Gene Name | SSE1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 693 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Has a calcium-dependent calmodulin-binding activity. Required for normal growth at various temperatures.. | |
| Protein Sequence | MSTPFGLDLGNNNSVLAVARNRGIDIVVNEVSNRSTPSVVGFGPKNRYLGETGKNKQTSNIKNTVANLKRIIGLDYHHPDFEQESKHFTSKLVELDDKKTGAEVRFAGEKHVFSATQLAAMFIDKVKDTVKQDTKANITDVCIAVPPWYTEEQRYNIADAARIAGLNPVRIVNDVTAAGVSYGIFKTDLPEGEEKPRIVAFVDIGHSSYTCSIMAFKKGQLKVLGTACDKHFGGRDFDLAITEHFADEFKTKYKIDIRENPKAYNRILTAAEKLKKVLSANTNAPFSVESVMNDVDVSSQLSREELEELVKPLLERVTEPVTKALAQAKLSAEEVDFVEIIGGTTRIPTLKQSISEAFGKPLSTTLNQDEAIAKGAAFICAIHSPTLRVRPFKFEDIHPYSVSYSWDKQVEDEDHMEVFPAGSSFPSTKLITLNRTGDFSMAASYTDITQLPPNTPEQIANWEITGVQLPEGQDSVPVKLKLRCDPSGLHTIEEAYTIEDIEVEEPIPLPEDAPEDAEQEFKKVTKTVKKDDLTIVAHTFGLDAKKLNELIEKENEMLAQDKLVAETEDRKNTLEEYIYTLRGKLEEEYAPFASDAEKTKLQGMLNKAEEWLYDEGFDSIKAKYIAKYEELASLGNIIRGRYLAKEEEKKQAIRSKQEASQMAAMAEKLAAQRKAEAEKKEEKKDTEGDVDMD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSTPFGLDL ------CCCCCCEEC | 44.80 | 9298649 | |
| 2 | Phosphorylation | ------MSTPFGLDL ------CCCCCCEEC | 44.80 | 28152593 | |
| 3 | Phosphorylation | -----MSTPFGLDLG -----CCCCCCEECC | 22.72 | 28152593 | |
| 32 | Phosphorylation | DIVVNEVSNRSTPSV CEEEEECCCCCCCCC | 21.98 | 28889911 | |
| 35 | Phosphorylation | VNEVSNRSTPSVVGF EEECCCCCCCCCCEE | 49.25 | 28889911 | |
| 36 | Phosphorylation | NEVSNRSTPSVVGFG EECCCCCCCCCCEEC | 19.15 | 21440633 | |
| 38 | Phosphorylation | VSNRSTPSVVGFGPK CCCCCCCCCCEECCC | 29.53 | 28152593 | |
| 45 | 2-Hydroxyisobutyrylation | SVVGFGPKNRYLGET CCCEECCCCCCCCCC | 55.20 | - | |
| 45 | Acetylation | SVVGFGPKNRYLGET CCCEECCCCCCCCCC | 55.20 | 24489116 | |
| 45 | Succinylation | SVVGFGPKNRYLGET CCCEECCCCCCCCCC | 55.20 | 23954790 | |
| 48 | Phosphorylation | GFGPKNRYLGETGKN EECCCCCCCCCCCCC | 28.58 | 28889911 | |
| 62 | Succinylation | NKQTSNIKNTVANLK CCCCCCHHHHHHHHH | 51.30 | 23954790 | |
| 64 | Phosphorylation | QTSNIKNTVANLKRI CCCCHHHHHHHHHHH | 18.92 | 28889911 | |
| 69 | 2-Hydroxyisobutyrylation | KNTVANLKRIIGLDY HHHHHHHHHHHCCCC | 41.16 | - | |
| 69 | Succinylation | KNTVANLKRIIGLDY HHHHHHHHHHHCCCC | 41.16 | 23954790 | |
| 85 | Phosphorylation | HPDFEQESKHFTSKL CCCHHHHHHHHHHCE | 30.99 | 24961812 | |
| 86 | Acetylation | PDFEQESKHFTSKLV CCHHHHHHHHHHCEE | 41.82 | 24489116 | |
| 86 | Ubiquitination | PDFEQESKHFTSKLV CCHHHHHHHHHHCEE | 41.82 | 23749301 | |
| 89 | Phosphorylation | EQESKHFTSKLVELD HHHHHHHHHCEEECC | 25.35 | 28889911 | |
| 90 | Phosphorylation | QESKHFTSKLVELDD HHHHHHHHCEEECCC | 24.05 | 28889911 | |
| 91 | Acetylation | ESKHFTSKLVELDDK HHHHHHHCEEECCCC | 54.19 | 24489116 | |
| 91 | Ubiquitination | ESKHFTSKLVELDDK HHHHHHHCEEECCCC | 54.19 | 22817900 | |
| 98 | Acetylation | KLVELDDKKTGAEVR CEEECCCCCCCCEEE | 52.48 | 24489116 | |
| 99 | 2-Hydroxyisobutyrylation | LVELDDKKTGAEVRF EEECCCCCCCCEEEE | 60.22 | - | |
| 99 | Acetylation | LVELDDKKTGAEVRF EEECCCCCCCCEEEE | 60.22 | 24489116 | |
| 99 | Succinylation | LVELDDKKTGAEVRF EEECCCCCCCCEEEE | 60.22 | 23954790 | |
| 114 | Phosphorylation | AGEKHVFSATQLAAM CCCCCEEEHHHHHHH | 29.35 | 21440633 | |
| 125 | 2-Hydroxyisobutyrylation | LAAMFIDKVKDTVKQ HHHHHHHHHHHHHHH | 46.50 | - | |
| 125 | Ubiquitination | LAAMFIDKVKDTVKQ HHHHHHHHHHHHHHH | 46.50 | 22106047 | |
| 127 | 2-Hydroxyisobutyrylation | AMFIDKVKDTVKQDT HHHHHHHHHHHHHCC | 54.12 | - | |
| 131 | 2-Hydroxyisobutyrylation | DKVKDTVKQDTKANI HHHHHHHHHCCCCCC | 44.54 | - | |
| 131 | Succinylation | DKVKDTVKQDTKANI HHHHHHHHHCCCCCC | 44.54 | 23954790 | |
| 186 | Acetylation | GVSYGIFKTDLPEGE CCCCEEEECCCCCCC | 38.93 | 24489116 | |
| 195 | 2-Hydroxyisobutyrylation | DLPEGEEKPRIVAFV CCCCCCCCCEEEEEE | 34.98 | - | |
| 195 | Acetylation | DLPEGEEKPRIVAFV CCCCCCCCCEEEEEE | 34.98 | 24489116 | |
| 195 | Ubiquitination | DLPEGEEKPRIVAFV CCCCCCCCCEEEEEE | 34.98 | 23749301 | |
| 222 | Acetylation | AFKKGQLKVLGTACD EEECCCEEEEEEECC | 27.76 | 22865919 | |
| 226 | Phosphorylation | GQLKVLGTACDKHFG CCEEEEEEECCHHCC | 21.68 | 28152593 | |
| 230 | Acetylation | VLGTACDKHFGGRDF EEEEECCHHCCCCCC | 40.49 | 24489116 | |
| 230 | Ubiquitination | VLGTACDKHFGGRDF EEEEECCHHCCCCCC | 40.49 | 23749301 | |
| 242 | Phosphorylation | RDFDLAITEHFADEF CCCEEEEHHHHHHHH | 20.14 | 17287358 | |
| 262 | Acetylation | IDIRENPKAYNRILT CCCCCCHHHHHHHHH | 75.08 | 24489116 | |
| 262 | Succinylation | IDIRENPKAYNRILT CCCCCCHHHHHHHHH | 75.08 | 23954790 | |
| 273 | Acetylation | RILTAAEKLKKVLSA HHHHHHHHHHHHHCC | 61.96 | 24489116 | |
| 273 | Ubiquitination | RILTAAEKLKKVLSA HHHHHHHHHHHHHCC | 61.96 | 23749301 | |
| 275 | Acetylation | LTAAEKLKKVLSANT HHHHHHHHHHHCCCC | 52.48 | 24489116 | |
| 311 | Acetylation | EELEELVKPLLERVT HHHHHHHHHHHHHCC | 42.44 | 24489116 | |
| 323 | 2-Hydroxyisobutyrylation | RVTEPVTKALAQAKL HCCHHHHHHHHHHCC | 41.45 | - | |
| 323 | Acetylation | RVTEPVTKALAQAKL HCCHHHHHHHHHHCC | 41.45 | 22865919 | |
| 323 | Ubiquitination | RVTEPVTKALAQAKL HCCHHHHHHHHHHCC | 41.45 | 23749301 | |
| 351 | Ubiquitination | TTRIPTLKQSISEAF CCCCCHHHHHHHHHH | 44.47 | 24961812 | |
| 353 | Phosphorylation | RIPTLKQSISEAFGK CCCHHHHHHHHHHCC | 26.88 | 19823750 | |
| 355 | Phosphorylation | PTLKQSISEAFGKPL CHHHHHHHHHHCCCC | 28.28 | 29136822 | |
| 360 | Acetylation | SISEAFGKPLSTTLN HHHHHHCCCCCCCCC | 36.01 | 24489116 | |
| 363 | Phosphorylation | EAFGKPLSTTLNQDE HHHCCCCCCCCCHHH | 28.07 | 21440633 | |
| 365 | Phosphorylation | FGKPLSTTLNQDEAI HCCCCCCCCCHHHHH | 21.97 | 29136822 | |
| 384 | Phosphorylation | AFICAIHSPTLRVRP CEEEECCCCCEEECC | 17.29 | 22369663 | |
| 386 | Phosphorylation | ICAIHSPTLRVRPFK EEECCCCCEEECCCC | 30.15 | 22369663 | |
| 393 | Acetylation | TLRVRPFKFEDIHPY CEEECCCCCCCCCCC | 50.99 | 24489116 | |
| 393 | Ubiquitination | TLRVRPFKFEDIHPY CEEECCCCCCCCCCC | 50.99 | 24961812 | |
| 400 | Phosphorylation | KFEDIHPYSVSYSWD CCCCCCCCEEEEECC | 13.93 | 24961812 | |
| 401 | Phosphorylation | FEDIHPYSVSYSWDK CCCCCCCEEEEECCC | 14.72 | 24961812 | |
| 403 | Phosphorylation | DIHPYSVSYSWDKQV CCCCCEEEEECCCCC | 13.91 | 24961812 | |
| 404 | Phosphorylation | IHPYSVSYSWDKQVE CCCCEEEEECCCCCC | 16.18 | 24961812 | |
| 405 | Phosphorylation | HPYSVSYSWDKQVED CCCEEEEECCCCCCC | 22.69 | 24961812 | |
| 423 | Phosphorylation | MEVFPAGSSFPSTKL EEEECCCCCCCCCEE | 30.80 | 22369663 | |
| 424 | Phosphorylation | EVFPAGSSFPSTKLI EEECCCCCCCCCEEE | 40.01 | 23749301 | |
| 427 | Phosphorylation | PAGSSFPSTKLITLN CCCCCCCCCEEEEEC | 35.84 | 22369663 | |
| 428 | Phosphorylation | AGSSFPSTKLITLNR CCCCCCCCEEEEECC | 30.06 | 21440633 | |
| 429 | Acetylation | GSSFPSTKLITLNRT CCCCCCCEEEEECCC | 42.08 | 24489116 | |
| 429 | Ubiquitination | GSSFPSTKLITLNRT CCCCCCCEEEEECCC | 42.08 | 23749301 | |
| 529 | Acetylation | KKVTKTVKKDDLTIV HHHHHCCCHHCEEEE | 56.57 | 24489116 | |
| 529 | Succinylation | KKVTKTVKKDDLTIV HHHHHCCCHHCEEEE | 56.57 | 23954790 | |
| 530 | Acetylation | KVTKTVKKDDLTIVA HHHHCCCHHCEEEEE | 52.73 | 24489116 | |
| 545 | Acetylation | HTFGLDAKKLNELIE EECCCCHHHHHHHHH | 58.42 | 24489116 | |
| 545 | Succinylation | HTFGLDAKKLNELIE EECCCCHHHHHHHHH | 58.42 | 23954790 | |
| 553 | Acetylation | KLNELIEKENEMLAQ HHHHHHHHHHHHHHH | 59.87 | 24489116 | |
| 562 | Acetylation | NEMLAQDKLVAETED HHHHHHCHHHHCCCH | 32.55 | 24489116 | |
| 571 | Acetylation | VAETEDRKNTLEEYI HHCCCHHHHHHHHHH | 67.61 | 24489116 | |
| 571 | Ubiquitination | VAETEDRKNTLEEYI HHCCCHHHHHHHHHH | 67.61 | 24961812 | |
| 584 | 2-Hydroxyisobutyrylation | YIYTLRGKLEEEYAP HHHHHHHHHHHHHCC | 46.41 | - | |
| 584 | Acetylation | YIYTLRGKLEEEYAP HHHHHHHHHHHHHCC | 46.41 | 24489116 | |
| 584 | Ubiquitination | YIYTLRGKLEEEYAP HHHHHHHHHHHHHCC | 46.41 | 23749301 | |
| 594 | Phosphorylation | EEYAPFASDAEKTKL HHHCCCCCHHHHHHH | 37.42 | 28889911 | |
| 598 | Acetylation | PFASDAEKTKLQGML CCCCHHHHHHHHHHH | 53.32 | 24489116 | |
| 599 | Phosphorylation | FASDAEKTKLQGMLN CCCHHHHHHHHHHHH | 28.61 | 22369663 | |
| 600 | 2-Hydroxyisobutyrylation | ASDAEKTKLQGMLNK CCHHHHHHHHHHHHH | 50.29 | - | |
| 607 | Ubiquitination | KLQGMLNKAEEWLYD HHHHHHHHHHHHHHH | 53.89 | 23749301 | |
| 621 | 2-Hydroxyisobutyrylation | DEGFDSIKAKYIAKY HCCCHHHHHHHHHHH | 42.66 | - | |
| 621 | Acetylation | DEGFDSIKAKYIAKY HCCCHHHHHHHHHHH | 42.66 | 24489116 | |
| 621 | Succinylation | DEGFDSIKAKYIAKY HCCCHHHHHHHHHHH | 42.66 | 23954790 | |
| 623 | 2-Hydroxyisobutyrylation | GFDSIKAKYIAKYEE CCHHHHHHHHHHHHH | 31.99 | - | |
| 623 | Ubiquitination | GFDSIKAKYIAKYEE CCHHHHHHHHHHHHH | 31.99 | 22817900 | |
| 627 | Acetylation | IKAKYIAKYEELASL HHHHHHHHHHHHHHC | 43.57 | 24489116 | |
| 627 | Succinylation | IKAKYIAKYEELASL HHHHHHHHHHHHHHC | 43.57 | 23954790 | |
| 627 | Ubiquitination | IKAKYIAKYEELASL HHHHHHHHHHHHHHC | 43.57 | 24961812 | |
| 633 | Phosphorylation | AKYEELASLGNIIRG HHHHHHHHCHHHHHH | 49.81 | 30377154 | |
| 642 | Phosphorylation | GNIIRGRYLAKEEEK HHHHHHHHHCCHHHH | 17.52 | 22369663 | |
| 645 | Acetylation | IRGRYLAKEEEKKQA HHHHHHCCHHHHHHH | 64.16 | 24489116 | |
| 645 | Succinylation | IRGRYLAKEEEKKQA HHHHHHCCHHHHHHH | 64.16 | 23954790 | |
| 649 | Acetylation | YLAKEEEKKQAIRSK HHCCHHHHHHHHHHH | 54.16 | 24489116 | |
| 655 | Phosphorylation | EKKQAIRSKQEASQM HHHHHHHHHHHHHHH | 32.36 | 23749301 | |
| 656 | Acetylation | KKQAIRSKQEASQMA HHHHHHHHHHHHHHH | 42.16 | 25381059 | |
| 656 | Ubiquitination | KKQAIRSKQEASQMA HHHHHHHHHHHHHHH | 42.16 | 23749301 | |
| 660 | Phosphorylation | IRSKQEASQMAAMAE HHHHHHHHHHHHHHH | 21.53 | 25752575 | |
| 668 | Acetylation | QMAAMAEKLAAQRKA HHHHHHHHHHHHHHH | 33.61 | 24489116 | |
| 668 | Ubiquitination | QMAAMAEKLAAQRKA HHHHHHHHHHHHHHH | 33.61 | 23749301 | |
| 683 | Ubiquitination | EAEKKEEKKDTEGDV HHHHHHHHCCCCCCC | 57.97 | 23749301 | |
| 684 | Ubiquitination | AEKKEEKKDTEGDVD HHHHHHHCCCCCCCC | 73.49 | 23749301 | |
| 686 | Phosphorylation | KKEEKKDTEGDVDMD HHHHHCCCCCCCCCC | 51.23 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HSP7F_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HSP7F_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HSP7F_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Proteome studies of Saccharomyces cerevisiae: identification andcharacterization of abundant proteins."; Garrels J.I., McLaughlin C.S., Warner J.R., Futcher B., Latter G.I.,Kobayashi R., Schwender B., Volpe T., Anderson D.S.,Mesquita-Fuentes R., Payne W.E.; Electrophoresis 18:1347-1360(1997). Cited for: ACETYLATION AT SER-2. | |
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-36 AND SER-660, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-242, AND MASSSPECTROMETRY. | |
