dbPTM

UTP21_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UTP21_YEAST
UniProt AC	Q06078
Protein Name	U3 small nucleolar RNA-associated protein 21
Gene Name	UTP21
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	939
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly..
Protein Sequence	MSIDLKKRKVEEDVRSRGKNSKIFSPFRIIGNVSNGVPFATGTLGSTFYIVTCVGKTFQIYDANTLHLLFVSEKETPSSIVALSAHFHYVYAAYENKVGIYKRGIEEHLLELETDANVEHLCIFGDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIVSLQHLATYLNKLTVVTKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVLDIIALGTVTGEVIMFNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGTSSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNSLKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLSASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALAIENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAMSQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMVSCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIVVIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGGCIDGIIVDNVATNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTIDESEFARMALPSTSVRGNDSMLSGALESNGGEDLNDIDFNTYTSLEQIDKELLTLSIGPRSKMNTLLHLDVIRKRSKPKEAPKKSEKLPFFLQLSGEKVGDEASVREGIAHETPEEIHRRDQEAQKKLDAEEQMNKFKVTGRLGFESHFTKQLREGSQSKDYSSLLATLINFSPAAVDLEIRSLNSFEPFDEIVWFIDALTQGLKSNKNFELYETFMSLLFKAHGDVIHANNKNQDIASALQNWEDVHKKEDRLDDLVKFCMGVAAFVTTA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSIDLKKRK ------CCCCHHHCC	25.47	22814378
16	Phosphorylation	KVEEDVRSRGKNSKI CHHHHHHHCCCCCCC	45.28	27717283
148	Acetylation	KKSDPQDKYPSEFYT ECCCCCCCCCCCCEE	54.54	24489116
258	Phosphorylation	ISSLSFRTDGSSHLS CEEEEEEECCCCCEE	42.58	27214570
409	Phosphorylation	VGGSTIKSKFPEIVA CCCHHHHHHCHHHHH	35.36	30377154
410	Acetylation	GGSTIKSKFPEIVAL CCHHHHHHCHHHHHH	60.99	24489116
541	Acetylation	STLLGKLKLDAPITA CCEEEEEECCCCEEE	48.05	24489116
602	Phosphorylation	PEGRWIVSASLDSTI CCCCEEEEEECCCCE	11.73	21126336
604	Phosphorylation	GRWIVSASLDSTIRT CCEEEEEECCCCEEE	25.79	21126336
680	Phosphorylation	FARMALPSTSVRGND HHHHHCCCCCCCCCC	33.88	30377154
682	Phosphorylation	RMALPSTSVRGNDSM HHHCCCCCCCCCCHH	17.72	25752575
722	Phosphorylation	QIDKELLTLSIGPRS HHCHHHHHCCCCCHH	30.96	22369663
724	Phosphorylation	DKELLTLSIGPRSKM CHHHHHCCCCCHHHC	21.92	22369663
752	Acetylation	KPKEAPKKSEKLPFF CCCCCCCCCCCCCEE	63.89	24489116
755	Acetylation	EAPKKSEKLPFFLQL CCCCCCCCCCEEEEE	69.42	24489116
763	Phosphorylation	LPFFLQLSGEKVGDE CCEEEEECCCCCCCH	31.76	21440633
772	Phosphorylation	EKVGDEASVREGIAH CCCCCHHHHHCCCCC	21.47	27214570
819	Acetylation	GFESHFTKQLREGSQ CCHHHHHHHHHCCCC	46.52	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UTP21_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UTP21_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UTP21_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UTP12_YEAST	DIP2	physical	14759368
PWP2_YEAST	PWP2	physical	14759368
UTP13_YEAST	UTP13	physical	14759368
UTP18_YEAST	UTP18	physical	14759368
UTP6_YEAST	UTP6	physical	14759368
UTP21_YEAST	UTP21	physical	14759368
PWP2_YEAST	PWP2	physical	12150911
UTP6_YEAST	UTP6	physical	12150911
UTP10_YEAST	UTP10	physical	12150911
UTP4_YEAST	UTP4	physical	12150911
UTP13_YEAST	UTP13	physical	12150911
UTP15_YEAST	UTP15	physical	12150911
MPP10_YEAST	MPP10	physical	15590835
UTP12_YEAST	DIP2	physical	16554755
PWP2_YEAST	PWP2	physical	16429126
UTP13_YEAST	UTP13	physical	16429126
UTP18_YEAST	UTP18	physical	16429126
UTP6_YEAST	UTP6	physical	16429126
UTP15_YEAST	UTP15	physical	16429126
UTP4_YEAST	UTP4	physical	16429126
UTP8_YEAST	UTP8	physical	17634288
UTP18_YEAST	UTP18	physical	18719252
SSB1_YEAST	SSB1	physical	19536198
MPP10_YEAST	MPP10	physical	20884785
UTP6_YEAST	UTP6	physical	20884785
PWP2_YEAST	PWP2	physical	18725399
UTP6_YEAST	UTP6	physical	18725399
UTP18_YEAST	UTP18	physical	18725399
UTP18_YEAST	UTP18	physical	24466140
PXR1_YEAST	PXR1	physical	24823796
APC11_YEAST	APC11	genetic	27708008
KIN28_YEAST	KIN28	genetic	27708008
TCPD_YEAST	CCT4	genetic	27708008
TIM22_YEAST	TIM22	genetic	27708008
SMC3_YEAST	SMC3	genetic	27708008
POB3_YEAST	POB3	genetic	27708008
RPC6_YEAST	RPC34	genetic	27708008
SGT1_YEAST	SGT1	genetic	27708008
APC5_YEAST	APC5	genetic	27708008
CLP1_YEAST	CLP1	genetic	27708008
MYO2_YEAST	MYO2	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
PHO80_YEAST	PHO80	genetic	27708008
TOP1_YEAST	TOP1	genetic	27708008
DDP1_YEAST	DDP1	genetic	27708008
NIP80_YEAST	NIP100	genetic	27708008
TFS2_YEAST	DST1	genetic	27708008
VAM7_YEAST	VAM7	genetic	27708008
SRO7_YEAST	SRO7	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
RFA1_YEAST	RFA1	genetic	27708008
CDC15_YEAST	CDC15	genetic	27708008
MPS1_YEAST	MPS1	genetic	27708008
ARP2_YEAST	ARP2	genetic	27708008
PRP9_YEAST	PRP9	genetic	27708008
NOP14_YEAST	NOP14	genetic	27708008
DNLI1_YEAST	CDC9	genetic	27708008
DAD1_YEAST	DAD1	genetic	27708008
FAL1_YEAST	FAL1	genetic	27708008
LCB2_YEAST	LCB2	genetic	27708008
DOP1_YEAST	DOP1	genetic	27708008
TAF12_YEAST	TAF12	genetic	27708008
CDC37_YEAST	CDC37	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
SRPR_YEAST	SRP101	genetic	27708008
FCF1_YEAST	FCF1	genetic	27708008
UTP5_YEAST	UTP5	genetic	27708008
UTP6_YEAST	UTP6	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
STT3_YEAST	STT3	genetic	27708008
TAF6_YEAST	TAF6	genetic	27708008
SLD3_YEAST	SLD3	genetic	27708008
CDC20_YEAST	CDC20	genetic	27708008
UTP9_YEAST	UTP9	genetic	27708008
DSN1_YEAST	DSN1	genetic	27708008
PSF2_YEAST	PSF2	genetic	27708008
ARP4_YEAST	ARP4	genetic	27708008
PRI2_YEAST	PRI2	genetic	27708008
MIF2_YEAST	MIF2	genetic	27708008
ORC3_YEAST	ORC3	genetic	27708008
COFI_YEAST	COF1	genetic	27708008
SPC3_YEAST	SPC3	genetic	27708008
TAF13_YEAST	TAF13	genetic	27708008
TAP42_YEAST	TAP42	genetic	27708008
UTP15_YEAST	UTP15	genetic	27708008
CBF3B_YEAST	CEP3	genetic	27708008
RRP5_YEAST	RRP5	genetic	27708008
NOP2_YEAST	NOP2	genetic	27708008
NAT10_YEAST	KRE33	genetic	27708008
CAP_YEAST	SRV2	genetic	27708008
BUR1_YEAST	SGV1	genetic	27708008
ORC4_YEAST	ORC4	genetic	27708008
SYIC_YEAST	ILS1	genetic	27708008
TECR_YEAST	TSC13	genetic	27708008
RRP42_YEAST	RRP42	genetic	27708008
DBF4_YEAST	DBF4	genetic	27708008
TFB1_YEAST	TFB1	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
HSF_YEAST	HSF1	genetic	27708008
PAN1_YEAST	PAN1	genetic	27708008
DPB11_YEAST	DPB11	genetic	27708008
FIP1_YEAST	FIP1	genetic	27708008
TIM14_YEAST	PAM18	genetic	27708008
NAB3_YEAST	NAB3	genetic	27708008
SYH_YEAST	HTS1	genetic	27708008
LTE1_YEAST	LTE1	genetic	27708008
KPR4_YEAST	PRS4	genetic	27708008
ETR1_YEAST	ETR1	genetic	27708008
FMP23_YEAST	FMP23	genetic	27708008
ECM8_YEAST	ECM8	genetic	27708008
IML3_YEAST	IML3	genetic	27708008
ATG12_YEAST	ATG12	genetic	27708008
MRC1_YEAST	MRC1	genetic	27708008
ATG15_YEAST	ATG15	genetic	27708008
PAT1_YEAST	PAT1	genetic	27708008
YCZ2_YEAST	YCR102C	genetic	27708008
PHO2_YEAST	PHO2	genetic	27708008
OST4_YEAST	OST4	genetic	27708008
RRP8_YEAST	RRP8	genetic	27708008
WDR59_YEAST	MTC5	genetic	27708008
MNN10_YEAST	MNN10	genetic	27708008
HSP78_YEAST	HSP78	genetic	27708008
SUM1_YEAST	SUM1	genetic	27708008
APT2_YEAST	APT2	genetic	27708008
CEM1_YEAST	CEM1	genetic	27708008
SA155_YEAST	SAP155	genetic	27708008
YGZ2_YEAST	YGL242C	genetic	27708008
ADH4_YEAST	ADH4	genetic	27708008
RME1_YEAST	RME1	genetic	27708008
OPI1_YEAST	OPI1	genetic	27708008
INM1_YEAST	INM1	genetic	27708008
PP2C7_YEAST	PTC7	genetic	27708008
PTPA1_YEAST	RRD1	genetic	27708008
IMPX_YEAST	IMP2	genetic	27708008
LSM1_YEAST	LSM1	genetic	27708008
RPA34_YEAST	RPA34	genetic	27708008
YJY1_YEAST	YJR011C	genetic	27708008
TCD2_YEAST	TCD2	genetic	27708008
FABG_YEAST	OAR1	genetic	27708008
MUD2_YEAST	MUD2	genetic	27708008
EF1G2_YEAST	TEF4	genetic	27708008
LST4_YEAST	LST4	genetic	27708008
MEH1_YEAST	MEH1	genetic	27708008
SHB17_YEAST	SHB17	genetic	27708008
CSI1_YEAST	CSI1	genetic	27708008
MAS5_YEAST	YDJ1	genetic	27708008
PFD4_YEAST	GIM3	genetic	27708008
VPS27_YEAST	VPS27	genetic	27708008
LDS2_YEAST	LDS2	genetic	27708008
KPR5_YEAST	PRS5	genetic	27708008
RRP6_YEAST	RRP6	genetic	27708008
HST3_YEAST	HST3	genetic	27708008
BUD21_YEAST	BUD21	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008
LIPA_YEAST	LIP5	genetic	27708008
FABD_YEAST	MCT1	genetic	27708008
KIN4_YEAST	KIN4	genetic	27708008
HAP5_YEAST	HAP5	genetic	27708008
EF1G1_YEAST	CAM1	genetic	27708008
GGPPS_YEAST	BTS1	genetic	27708008
NCBP2_YEAST	CBC2	genetic	27708008
NEW1_YEAST	NEW1	genetic	27708008
AP1G1_YEAST	APL4	genetic	27708008
TKT1_YEAST	TKL1	genetic	27708008
KAR3_YEAST	KAR3	genetic	27708008
NTH1_YEAST	NTG1	genetic	27708008
YAJ9_YEAST	YAR029W	genetic	27708008
SWC5_YEAST	SWC5	genetic	27708008
NHP10_YEAST	NHP10	genetic	27708008
PP2C1_YEAST	PTC1	genetic	27708008
BAP3_YEAST	BAP3	genetic	27708008
YG1X_YEAST	YGR050C	genetic	27708008
RL8A_YEAST	RPL8A	genetic	27708008
DSE2_YEAST	DSE2	genetic	27708008
ATG32_YEAST	ATG32	genetic	27708008
YL032_YEAST	YLL032C	genetic	27708008
TRI1_YEAST	TRI1	genetic	27708008
PET8_YEAST	PET8	genetic	27708008
OCA2_YEAST	OCA2	genetic	27708008
PMS1_YEAST	PMS1	genetic	27708008
CY1_YEAST	CYT1	genetic	27708008
CHL1_YEAST	CHL1	genetic	27708008
LGE1_YEAST	LGE1	genetic	27708008
PWP2_YEAST	PWP2	physical	27330138
UTP18_YEAST	UTP18	physical	27330138
HSC82_YEAST	HSC82	physical	24647762

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UTP21_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-682; SER-763 ANDSER-772, AND MASS SPECTROMETRY.	18407956 [Abstract]