| UniProt ID | NAT10_YEAST | |
|---|---|---|
| UniProt AC | P53914 | |
| Protein Name | RNA cytidine acetyltransferase {ECO:0000255|HAMAP-Rule:MF_03211, ECO:0000305} | |
| Gene Name | KRE33 {ECO:0000303|PubMed:12663529} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1056 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1280 and 1773 in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. [PubMed: 25086048] | |
| Protein Sequence | MAKKAIDSRIPSLIRNGVQTKQRSIFVIVGDRARNQLPNLHYLMMSADLKMNKSVLWAYKKKLLGFTSHRKKRENKIKKEIKRGTREVNEMDPFESFISNQNIRYVYYKESEKILGNTYGMCILQDFEALTPNLLARTIETVEGGGIVVILLKSMSSLKQLYTMTMDVHARYRTEAHGDVVARFNERFILSLGSNPNCLVVDDELNVLPLSGAKNVKPLPPKEDDELPPKQLELQELKESLEDVQPAGSLVSLSKTVNQAHAILSFIDAISEKTLNFTVALTAGRGRGKSAALGISIAAAVSHGYSNIFVTSPSPENLKTLFEFIFKGFDALGYQEHIDYDIIQSTNPDFNKAIVRVDIKRDHRQTIQYIVPQDHQVLGQAELVVIDEAAAIPLPIVKNLLGPYLVFMASTINGYEGTGRSLSLKLIQQLRNQNNTSGRESTQTAVVSRDNKEKDSHLHSQSRQLREISLDEPIRYAPGDPIEKWLNKLLCLDVTLIKNPRFATRGTPHPSQCNLFVVNRDTLFSYHPVSENFLEKMMALYVSSHYKNSPNDLQLMSDAPAHKLFVLLPPIDPKDGGRIPDPLCVIQIALEGEISKESVRNSLSRGQRAGGDLIPWLISQQFQDEEFASLSGARIVRIATNPEYASMGYGSRAIELLRDYFEGKFTDMSEDVRPKDYSIKRVSDKELAKTNLLKDDVKLRDAKTLPPLLLKLSEQPPHYLHYLGVSYGLTQSLHKFWKNNSFVPVYLRQTANDLTGEHTCVMLNVLEGRESNWLVEFAKDFRKRFLSLLSYDFHKFTAVQALSVIESSKKAQDLSDDEKHDNKELTRTHLDDIFSPFDLKRLDSYSNNLLDYHVIGDMIPMLALLYFGDKMGDSVKLSSVQSAILLAIGLQRKNIDTIAKELNLPSNQTIAMFAKIMRKMSQYFRQLLSQSIEETLPNIKDDAIAEMDGEEIKNYNAAEALDQMEEDLEEAGSEAVQAMREKQKELINSLNLDKYAINDNSEEWAESQKSLEIAAKAKGVVSLKTGKKRTTEKAEDIYRQEMKAMKKPRKSKKAAN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 96 | Phosphorylation | NEMDPFESFISNQNI CCCCHHHHHHHCCCE | 30377154 | ||
| 109 | Acetylation | NIRYVYYKESEKILG CEEEEEEECHHHHHC | 22865919 | ||
| 255 | Ubiquitination | GSLVSLSKTVNQAHA CHHHHHHHHHHHHHH | 17644757 | ||
| 273 | Ubiquitination | FIDAISEKTLNFTVA HHHHHCCCCCCEEEE | 17644757 | ||
| 425 | Acetylation | TGRSLSLKLIQQLRN CCHHHHHHHHHHHHH | 24489116 | ||
| 441 | Phosphorylation | NNTSGRESTQTAVVS CCCCCCCCCEEEEEE | 28889911 | ||
| 442 | Phosphorylation | NTSGRESTQTAVVSR CCCCCCCCEEEEEEC | 25752575 | ||
| 460 | Phosphorylation | EKDSHLHSQSRQLRE CCCCCCCCCCHHHHH | 30377154 | ||
| 484 | Acetylation | APGDPIEKWLNKLLC CCCCHHHHHHHHHHC | 24489116 | ||
| 511 | Phosphorylation | TRGTPHPSQCNLFVV CCCCCCHHHCEEEEE | 23749301 | ||
| 563 | Ubiquitination | MSDAPAHKLFVLLPP CCCCCCCEEEEECCC | 17644757 | ||
| 574 | Ubiquitination | LLPPIDPKDGGRIPD ECCCCCCCCCCCCCC | 17644757 | ||
| 574 | Acetylation | LLPPIDPKDGGRIPD ECCCCCCCCCCCCCC | 24489116 | ||
| 602 | Phosphorylation | SKESVRNSLSRGQRA CHHHHHHHHHHCHHC | 30377154 | ||
| 669 | Phosphorylation | EGKFTDMSEDVRPKD CCCCCCCCCCCCCCC | 23749301 | ||
| 685 | Acetylation | SIKRVSDKELAKTNL CCCCCCHHHHHHHCC | 24489116 | ||
| 694 | Acetylation | LAKTNLLKDDVKLRD HHHHCCCCCCCHHCC | 22865919 | ||
| 698 | Acetylation | NLLKDDVKLRDAKTL CCCCCCCHHCCCCCC | 24489116 | ||
| 738 | Ubiquitination | QSLHKFWKNNSFVPV HHHHHHHHCCCCCEE | 17644757 | ||
| 738 | Acetylation | QSLHKFWKNNSFVPV HHHHHHHHCCCCCEE | 24489116 | ||
| 797 | Phosphorylation | SYDFHKFTAVQALSV CCCHHHHHHHHHHHH | 21126336 | ||
| 803 | Phosphorylation | FTAVQALSVIESSKK HHHHHHHHHHHHCCC | 21126336 | ||
| 826 | Phosphorylation | KHDNKELTRTHLDDI CCCCHHHHHHHHHHC | 21440633 | ||
| 840 | Acetylation | IFSPFDLKRLDSYSN CCCCCCHHHHHHCCC | 24489116 | ||
| 897 | Phosphorylation | LQRKNIDTIAKELNL CCCCCHHHHHHHCCC | 27017623 | ||
| 915 | Acetylation | QTIAMFAKIMRKMSQ HHHHHHHHHHHHHHH | 24489116 | ||
| 973 | Phosphorylation | EDLEEAGSEAVQAMR HHHHHHHHHHHHHHH | 21440633 | ||
| 989 | Phosphorylation | KQKELINSLNLDKYA HHHHHHHHCCCCHHC | 21440633 | ||
| 995 | Phosphorylation | NSLNLDKYAINDNSE HHCCCCHHCCCCCHH | 19823750 | ||
| 1001 | Phosphorylation | KYAINDNSEEWAESQ HHCCCCCHHHHHHHH | 19823750 | ||
| 1007 | Phosphorylation | NSEEWAESQKSLEIA CHHHHHHHHHHHHHH | 28889911 | ||
| 1010 | Phosphorylation | EWAESQKSLEIAAKA HHHHHHHHHHHHHHH | 28889911 | ||
| 1024 | Acetylation | AKGVVSLKTGKKRTT HCCEEEECCCCCCCC | 25381059 | ||
| 1033 | Acetylation | GKKRTTEKAEDIYRQ CCCCCCHHHHHHHHH | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NAT10_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NAT10_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NAT10_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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