HFD1_YEAST - dbPTM
HFD1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HFD1_YEAST
UniProt AC Q04458
Protein Name Fatty aldehyde dehydrogenase HFD1
Gene Name HFD1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 532
Subcellular Localization Mitochondrion outer membrane
Single-pass membrane protein . Endosome membrane
Single-pass membrane protein . Cytoplasmic granule membrane
Single-pass membrane protein .
Protein Description Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid..
Protein Sequence MSNDGSKILNYTPVSKIDEIVEISRNFFFEKQLKLSHENNPRKKDLEFRQLQLKKLYYAVKDHEEELIDAMYKDFHRNKIESVLNETTKLMNDILHLIEILPKLIKPRRVSDSSPPFMFGKTIVEKISRGSVLIIAPFNFPLLLAFAPLAAALAAGNTIVLKPSELTPHTAVVMENLLTTAGFPDGLIQVVQGAIDETTRLLDCGKFDLIFYTGSPRVGSIVAEKAAKSLTPCVLELGGKSPTFITENFKASNIKIALKRIFFGAFGNSGQICVSPDYLLVHKSIYPKVIKECESVLNEFYPSFDEQTDFTRMIHEPAYKKAVASINSTNGSKIVPSKISINSDTEDLCLVPPTIVYNIGWDDPLMKQENFAPVLPIIEYEDLDETINKIIEEHDTPLVQYIFSDSQTEINRILTRLRSGDCVVGDTVIHVGITDAPFGGIGTSGYGNYGGYYGFNTFSHERTIFKQPYWNDFTLFMRYPPNSAQKEKLVRFAMERKPWFDRNGNNKWGLRQYFSLSAAVILISTIYAHCSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationDGSKILNYTPVSKID
CCCCCCCCCCCCHHH		14.6929688323
12PhosphorylationGSKILNYTPVSKIDE
CCCCCCCCCCCHHHH		19.0129688323
15PhosphorylationILNYTPVSKIDEIVE
CCCCCCCCHHHHHHH		25.7129688323
16UbiquitinationLNYTPVSKIDEIVEI
CCCCCCCHHHHHHHH		55.1824961812
73AcetylationELIDAMYKDFHRNKI
HHHHHHHHHHHHHHH		40.6124489116
82PhosphorylationFHRNKIESVLNETTK
HHHHHHHHHHHHHHH		35.0629734811
111PhosphorylationLIKPRRVSDSSPPFM
HHCCCCCCCCCCCCC		29.9322369663
113PhosphorylationKPRRVSDSSPPFMFG
CCCCCCCCCCCCCCC		36.9228889911
114PhosphorylationPRRVSDSSPPFMFGK
CCCCCCCCCCCCCCH		41.4027717283
121AcetylationSPPFMFGKTIVEKIS
CCCCCCCHHHHHHHH		24.6624489116
220PhosphorylationTGSPRVGSIVAEKAA
ECCCCHHHHHHHHHH		15.8427214570
225UbiquitinationVGSIVAEKAAKSLTP
HHHHHHHHHHHHCCC		43.8623749301
231PhosphorylationEKAAKSLTPCVLELG
HHHHHHCCCEEHHCC		23.0227214570
241PhosphorylationVLELGGKSPTFITEN
EHHCCCCCCEEECCC		32.2328889911
243PhosphorylationELGGKSPTFITENFK
HCCCCCCEEECCCCH		34.4628889911
250UbiquitinationTFITENFKASNIKIA
EEECCCCHHHCHHHH		63.5923749301
252PhosphorylationITENFKASNIKIALK
ECCCCHHHCHHHHHH		39.4128889911
295PhosphorylationKVIKECESVLNEFYP
HHHHHHHHHHHHHCC		43.4927214570
328PhosphorylationKAVASINSTNGSKIV
HHHEECCCCCCCEEC		22.9128889911
333UbiquitinationINSTNGSKIVPSKIS
CCCCCCCEECCCEEE		49.4723749301
406PhosphorylationVQYIFSDSQTEINRI
HHHHCCCCHHHHHHH		37.4927214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HFD1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HFD1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HFD1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NAP1_YEASTNAP1physical
16554755
SLM2_YEASTSLM2genetic
20526336
STV1_YEASTSTV1genetic
20526336
JEN1_YEASTJEN1genetic
20526336
TOR2_YEASTTOR2genetic
20526336
CSG2_YEASTCSG2genetic
21987634
FBRL_YEASTNOP1genetic
21987634
RGP1_YEASTRGP1genetic
21987634
MS116_YEASTMSS116genetic
21987634
PEP7_YEASTPEP7genetic
21987634
RPB7_YEASTRPB7genetic
21987634
SNF1_YEASTSNF1genetic
21987634
LAS1_YEASTLAS1genetic
21987634
RIC1_YEASTRIC1genetic
21987634
YPT6_YEASTYPT6genetic
21987634
VPS27_YEASTVPS27genetic
21987634
SLG1_YEASTSLG1genetic
21987634
AIM44_YEASTAIM44genetic
21987634
SWC4_YEASTSWC4genetic
27708008
RPAB1_YEASTRPB5genetic
27708008
CDK1_YEASTCDC28genetic
27708008
ARP2_YEASTARP2genetic
27708008
TPIS_YEASTTPI1genetic
27708008
RPB7_YEASTRPB7genetic
27708008
GPI19_YEASTGPI19genetic
27708008
CDC4_YEASTCDC4genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
SPC97_YEASTSPC97genetic
27708008
STS1_YEASTSTS1genetic
27708008
IF2A_YEASTSUI2genetic
27708008
RFC2_YEASTRFC2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
FNTA_YEASTRAM2genetic
27708008
PRI2_YEASTPRI2genetic
27708008
PRP16_YEASTPRP16genetic
27708008
STU2_YEASTSTU2genetic
27708008
SYH_YEASTHTS1genetic
27708008
BUR1_YEASTSGV1genetic
27708008
PRP4_YEASTPRP4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HFD1_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory