STV1_YEAST - dbPTM
STV1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STV1_YEAST
UniProt AC P37296
Protein Name V-type proton ATPase subunit a, Golgi isoform
Gene Name STV1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 890
Subcellular Localization Endosome membrane
Multi-pass membrane protein. Golgi apparatus membrane
Multi-pass membrane protein.
Protein Description Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. Is present only in Golgi- and endosome-residing V-ATPase complexes. Enzymes containing this subunit have a 4-fold lower ratio of proton transport to ATP hydrolysis than complexes containing the vacuolar isoform and do not dissociate V1 and V0 in response to glucose depletion. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
Protein Sequence MNQEEAIFRSADMTYVQLYIPLEVIREVTFLLGKMSVFMVMDLNKDLTAFQRGYVNQLRRFDEVERMVGFLNEVVEKHAAETWKYILHIDDEGNDIAQPDMADLINTMEPLSLENVNDMVKEITDCESRARQLDESLDSLRSKLNDLLEQRQVIFECSKFIEVNPGIAGRATNPEIEQEERDVDEFRMTPDDISETLSDAFSFDDETPQDRGALGNDLTRNQSVEDLSFLEQGYQHRYMITGSIRRTKVDILNRILWRLLRGNLIFQNFPIEEPLLEGKEKVEKDCFIIFTHGETLLKKVKRVIDSLNGKIVSLNTRSSELVDTLNRQIDDLQRILDTTEQTLHTELLVIHDQLPVWSAMTKREKYVYTTLNKFQQESQGLIAEGWVPSTELIHLQDSLKDYIETLGSEYSTVFNVILTNKLPPTYHRTNKFTQAFQSIVDAYGIATYKEINAGLATVVTFPFMFAIMFGDMGHGFILFLMALFLVLNERKFGAMHRDEIFDMAFTGRYVLLLMGAFSVYTGLLYNDIFSKSMTIFKSGWQWPSTFRKGESIEAKKTGVYPFGLDFAWHGTDNGLLFSNSYKMKLSILMGYAHMTYSFMFSYINYRAKNSKVDIIGNFIPGLVFMQSIFGYLSWAIVYKWSKDWIKDDKPAPGLLNMLINMFLAPGTIDDQLYSGQAKLQVVLLLAALVCVPWLLLYKPLTLRRLNKNGGGGRPHGYQSVGNIEHEEQIAQQRHSAEGFQGMIISDVASVADSINESVGGGEQGPFNFGDVMIHQVIHTIEFCLNCISHTASYLRLWALSLAHAQLSSVLWDMTISNAFSSKNSGSPLAVMKVVFLFAMWFVLTVCILVFMEGTSAMLHALRLHWVEAMSKFFEGEGYAYEPFSFRAIIE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MNQEEAIF
-------CCHHHHHH		12.0222814378
143UbiquitinationSLDSLRSKLNDLLEQ
HHHHHHHHHHHHHHH		44.8917644757
159UbiquitinationQVIFECSKFIEVNPG
HHHHHCCCCEECCCC		63.1217644757
172PhosphorylationPGIAGRATNPEIEQE
CCCCCCCCCHHHHHH		50.3627214570
189PhosphorylationDVDEFRMTPDDISET
CHHHHCCCHHHHHHH		21.2228889911
194PhosphorylationRMTPDDISETLSDAF
CCCHHHHHHHHHHHC		31.3630377154
196PhosphorylationTPDDISETLSDAFSF
CHHHHHHHHHHHCCC		25.4427738172
198PhosphorylationDDISETLSDAFSFDD
HHHHHHHHHHCCCCC		34.0228889911
202PhosphorylationETLSDAFSFDDETPQ
HHHHHHCCCCCCCCC		29.5027214570
219PhosphorylationGALGNDLTRNQSVED
CCCCCCCCCCCCHHH		30.3628889911
223PhosphorylationNDLTRNQSVEDLSFL
CCCCCCCCHHHHHHH		30.9022369663
228PhosphorylationNQSVEDLSFLEQGYQ
CCCHHHHHHHHHHCC		39.8622369663
234PhosphorylationLSFLEQGYQHRYMIT
HHHHHHHCCEEEEEC		10.8029136822
537UbiquitinationSKSMTIFKSGWQWPS
HCCCEEECCCCCCCC		44.1817644757
548UbiquitinationQWPSTFRKGESIEAK
CCCCCCCCCCCEECH		63.9417644757
551PhosphorylationSTFRKGESIEAKKTG
CCCCCCCCEECHHCC		34.1021126336
586PhosphorylationNSYKMKLSILMGYAH
CCHHHHHHHHHHCCH		14.2527017623
596PhosphorylationMGYAHMTYSFMFSYI
HHCCHHHHHHHHHHH		7.7327017623
605PhosphorylationFMFSYINYRAKNSKV
HHHHHHHHCCCCCCE		11.4627017623
707UbiquitinationLTLRRLNKNGGGGRP
HHHHHCCCCCCCCCC		62.6517644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STV1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STV1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STV1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VATA_YEASTVMA1physical
11592965
VATB_YEASTVMA2physical
11592965
VATH_YEASTVMA13physical
11592965
VATC_YEASTVMA5physical
11592965
VA0D_YEASTVMA6physical
11592965
VATD_YEASTVMA8physical
11592965
VATE_YEASTVMA4physical
11592965
VATF_YEASTVMA7physical
11592965
VATG_YEASTVMA10physical
11592965
RGP1_YEASTRGP1genetic
16269340
RIC1_YEASTRIC1genetic
16269340
FAR8_YEASTFAR8genetic
16269340
AP3D_YEASTAPL5genetic
16269340
SWA2_YEASTSWA2genetic
16269340
AP3B_YEASTAPL6genetic
16269340
AP3M_YEASTAPM3genetic
16269340
SCS7_YEASTSCS7genetic
16269340
ATC1_YEASTPMR1genetic
16269340
VPH1_YEASTVPH1physical
17565997
VATH_YEASTVMA13physical
18467557
RS8A_YEASTRPS8Agenetic
20093466
RS8B_YEASTRPS8Agenetic
20093466
UGX2_YEASTUGX2genetic
20093466
EMP47_YEASTEMP47genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
PALF_YEASTRIM8genetic
20093466
COG7_YEASTCOG7genetic
20093466
EFM1_YEASTEFM1genetic
20093466
PACC_YEASTRIM101genetic
20093466
PLMT_YEASTOPI3genetic
20093466
MNS1_YEASTMNS1genetic
20093466
IXR1_YEASTIXR1genetic
20093466
NST1_YEASTNST1genetic
20093466
MED9_YEASTCSE2genetic
20093466
VPH1_YEASTVPH1genetic
20093466
SUR1_YEASTSUR1genetic
20093466
PMA2_YEASTPMA2genetic
20093466
ATC4_YEASTDNF2physical
16093310
TMEDA_YEASTERV25physical
16093310
VPH1_YEASTVPH1genetic
16926153
TAT1_YEASTTAT1genetic
20526336
SYS1_YEASTSYS1genetic
20526336
YPK2_YEASTYPK2genetic
20526336
VPS16_YEASTVPS16genetic
20526336
SEG1_YEASTSEG1genetic
20526336
VPH1_YEASTVPH1genetic
22169356
SSB1_YEASTSSB1physical
22940862
MED3_YEASTPGD1physical
22875988
SYSM_YEASTDIA4physical
22875988
MMR1_YEASTMMR1physical
22875988
NUF2_YEASTNUF2physical
22875988
VPH1_YEASTVPH1genetic
22496448
ARF1_YEASTARF1physical
25002144
HUR1_YEASTHUR1genetic
27708008
UBP13_YEASTUBP13genetic
27708008
EMP47_YEASTEMP47genetic
27708008
COG7_YEASTCOG7genetic
27708008
GET1_YEASTGET1genetic
27708008
MED5_YEASTNUT1genetic
27708008
TOS2_YEASTTOS2genetic
27708008
SMI1_YEASTSMI1genetic
27708008
PHO81_YEASTPHO81genetic
27708008
EFM1_YEASTEFM1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
VPS35_YEASTVPS35genetic
27708008
ILM1_YEASTILM1genetic
27708008
MNS1_YEASTMNS1genetic
27708008
IXR1_YEASTIXR1genetic
27708008
SKY1_YEASTSKY1genetic
27708008
NST1_YEASTNST1genetic
27708008
SFL1_YEASTSFL1genetic
27708008
VPH1_YEASTVPH1genetic
27708008
PMA2_YEASTPMA2genetic
27708008
SGF11_YEASTSGF11genetic
27708008
SUR1_YEASTSUR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STV1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223 AND SER-228, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223, AND MASSSPECTROMETRY.

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