| UniProt ID | VA0D_YEAST | |
|---|---|---|
| UniProt AC | P32366 | |
| Protein Name | V-type proton ATPase subunit d | |
| Gene Name | VMA6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 345 | |
| Subcellular Localization |
Vacuole membrane Peripheral membrane protein . |
|
| Protein Description | Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.. | |
| Protein Sequence | MEGVYFNIDNGFIEGVVRGYRNGLLSNNQYINLTQCDTLEDLKLQLSSTDYGNFLSSVSSESLTTSLIQEYASSKLYHEFNYIRDQSSGSTRKFMDYITYGYMIDNVALMITGTIHDRDKGEILQRCHPLGWFDTLPTLSVATDLESLYETVLVDTPLAPYFKNCFDTAEELDDMNIEIIRNKLYKAYLEDFYNFVTEEIPEPAKECMQTLLGFEADRRSINIALNSLQSSDIDPDLKSDLLPNIGKLYPLATFHLAQAQDFEGVRAALANVYEYRGFLETGNLEDHFYQLEMELCRDAFTQQFAISTVWAWMKSKEQEVRNITWIAECIAQNQRERINNYISVY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEGVYFNI -------CCCEEEEE | 10.24 | 22814378 | |
| 5 | Phosphorylation | ---MEGVYFNIDNGF ---CCCEEEEECCCC | 11.19 | 28132839 | |
| 120 | Ubiquitination | GTIHDRDKGEILQRC CEECCCCCCHHHHHC | 60.38 | 23749301 | |
| 247 | Ubiquitination | DLLPNIGKLYPLATF CCCCCCHHHHHHHHH | 40.84 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VA0D_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VA0D_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VA0D_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| VATF_YEAST | VMA7 | physical | 16429126 | |
| VPH2_YEAST | VPH2 | physical | 16429126 | |
| YAP6_YEAST | YAP6 | physical | 11283351 | |
| MTH1_YEAST | MTH1 | physical | 11283351 | |
| VMA22_YEAST | VMA22 | physical | 11283351 | |
| YJ9I_YEAST | YJR141W | physical | 11283351 | |
| YAP4_YEAST | CIN5 | physical | 11283351 | |
| STD1_YEAST | STD1 | physical | 11283351 | |
| VATE_YEAST | VMA4 | physical | 11283351 | |
| VPH1_YEAST | VPH1 | physical | 18467557 | |
| VATH_YEAST | VMA13 | physical | 18467557 | |
| VATG_YEAST | VMA10 | physical | 19344662 | |
| RAD1_YEAST | RAD1 | genetic | 17093137 | |
| RAD52_YEAST | RAD52 | genetic | 17093137 | |
| DPOZ_YEAST | REV3 | genetic | 17093137 | |
| VPH1_YEAST | VPH1 | physical | 19289121 | |
| VATA_YEAST | VMA1 | physical | 19289121 | |
| SSD1_YEAST | SSD1 | genetic | 20093466 | |
| MOG1_YEAST | MOG1 | genetic | 20093466 | |
| CSF1_YEAST | CSF1 | genetic | 20093466 | |
| VPS9_YEAST | VPS9 | genetic | 20093466 | |
| ERG6_YEAST | ERG6 | genetic | 20093466 | |
| IRA2_YEAST | IRA2 | genetic | 20093466 | |
| TLG2_YEAST | TLG2 | genetic | 20093466 | |
| YP153_YEAST | YPR153W | genetic | 20093466 | |
| SRS2_YEAST | SRS2 | genetic | 21459050 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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